DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and Zfp87

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_573491.2	Gene:	Zfp87 / 170763	MGIID:	107768	Length:	540	Species:	Mus musculus

Alignment Length:	523	Identity:	168/523 - (32%)
Similarity:	249/523 - (47%)	Gaps:	62/523 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TFEEELIFISNSDFEELE-------SEIKIENFCSYGKDLEPVKGVPSKLKTCKSKIAK------ 71
            :|.:..|..|..::|.||       .::.:||:...         |...|.:||..:..
Mouse     6 SFRDVAIDFSAEEWECLEPAQWNLYRDVMLENYSHL---------VFLGLASCKPYLVTFLEQRQ 61

  Fly    72 -----KRP----LRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKR 127
                 |||    :......:||.:..|||.....|....|:|..|:|::|..|.|.|...:....
Mouse    62 EPSVVKRPAAATVHPGGKPYKCQEFDKTFDWNSLLLQRQRVHPVEKPYKCEECGKVFSAHSALSI 126

  Fly   128 HLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEER 191
            |...|. ::|:||..|.|.|:..|:|..|...|:|::|:||.:|:.:|...|.|:.|.||||.|.
Mouse   127 HQRIHTGEKPYKCEECGKAFSTRSALYIHKKIHSGDKPYKCEECAKAFYFPSLLKQHQRTHSAEN 191

  Fly   192 PFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHA-ERSFKCTQCPK 255
            ..:|..|.|||...|.|::|.|.|....|::|..|.|:|...|.|::|...|: |:.::|.:|.|
Mouse   192 LCKCEECGKAFYLPSFLKQHQRIHSAENPYRCEECGKAFSYPSTLKQHQRIHSGEKPYRCEECGK 256

  Fly   256 TFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYR 320
            .|.::.....|.|:|.||.|::|..|.:||...|.|:.|.:.|:|.:|.||..|.:.|...|...
Mouse   257 AFRRSTYFHQHQRIHTGEKPYQCEECGKTFYYRSNLKGHQIIHSGVKPYKCEVCGSMFRTSSDLS 321

  Fly   321 VHVRL----------------------------HTRERQYKCAECSKSFFKKSHLVEHQQVHTGE 357
            .|.|:                            |:||:.|||.||.|:|...|.|.|||::|:|.
Mouse   322 KHQRIHAEVKLYSCEECGKAFSTHSYLIRHKLGHSREKPYKCEECGKTFCYPSILKEHQRIHSGV 386

  Fly   358 RPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCS 422
            :|:.|..|...|:.|:.|..|...|...|:..|..|.|.|...|.|:.|...|:|:..::|..|.
Mouse   387 KPYNCEICGSMFRTRSELSKHQRIHAEVKLYNCEECGKAFSTHSYLMRHRLGHSGEKPYKCEECG 451

  Fly   423 KSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSL 487
            |||:..|.|..|.|.|: :.|:||..|.|:|...:...:|.|.|||||||||..|...::..|.|
Mouse   452 KSYSYPSLLKEHQRIHS-QNPYKCDVCGKVFCTRSGRSKHQRIHTGEKPYKCEDCGKGFSTHSYL 515

  Fly   488 GRH 490
            ..|
Mouse   516 TLH 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	150/437 (34%)
		C2H2 Zn finger	84..104	CDD:275368	6/19 (32%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	6/47 (13%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	9/19 (47%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
Zfp87	NP_573491.2	KRAB	5..65	CDD:214630	12/67 (18%)
		KRAB	5..44	CDD:279668	9/46 (20%)
		C2H2 Zn finger	83..103	CDD:275368	6/19 (32%)
		COG5048	107..472	CDD:227381	123/365 (34%)
		C2H2 Zn finger	111..131	CDD:275368	5/19 (26%)
		zf-H2C2_2	123..148	CDD:290200	8/24 (33%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		zf-H2C2_2	208..232	CDD:290200	9/23 (39%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		zf-H2C2_2	236..260	CDD:290200	8/23 (35%)
		C2H2 Zn finger	251..271	CDD:275368	6/19 (32%)
		zf-H2C2_2	266..288	CDD:290200	10/21 (48%)
		C2H2 Zn finger	279..299	CDD:275368	7/19 (37%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	0/19 (0%)
		C2H2 Zn finger	363..383	CDD:275368	10/19 (53%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	474..494	CDD:275368	6/19 (32%)
		zf-H2C2_2	489..511	CDD:290200	12/21 (57%)
		C2H2 Zn finger	502..522	CDD:275368	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900