DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF92

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_689839.1	Gene:	ZNF92 / 168374	HGNCID:	13168	Length:	586	Species:	Homo sapiens

Alignment Length:	504	Identity:	170/504 - (33%)
Similarity:	247/504 - (49%)	Gaps:	38/504 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VDQRPVKDEPPQEDTFEEELIFISNSDFEELESEIKIENFCSYG-------KDLEPV-------- 55
            ||:.||......:|.:.|..|   ...|:    ::.:..:..||       ||.:.|
Human    71 VDKTPVMCSHFAQDVWPEHSI---KDSFQ----KVILRTYGKYGHENLQLRKDHKSVDACKVYKG 128

  Fly    56 --KGVPSKLKTCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKS 118
              .|:...|.|..|||            |:|.:..|.|.:..|:..:...|..::||:|.:..||
Human   129 GYNGLNQCLTTTDSKI------------FQCDKYVKVFHKFPNVNRNKIRHTGKKPFKCKNRGKS 181

  Fly   119 FGRRTHYKRHLLKHEKR-PHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQV 182
            |...:...:|...|.:. .:||..|.|.|..:|:|.:|...||||:|:||.:|..:|.|.|:|..
Human   182 FCMLSQLTQHKKIHTREYSYKCEECGKAFNWSSTLTKHKIIHTGEKPYKCEECGKAFNRSSNLTK 246

  Fly   183 HLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHAE-R 246
            |...|:.|:|::|..|.|||..:|.|.:|.|.|.|.:|:||..|.|:|...|||.||...|.| :
Human   247 HKIIHTGEKPYKCEECGKAFNRSSTLTKHKRIHTEEKPYKCEECGKAFNQFSILNKHKRIHMEDK 311

  Fly   247 SFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSA 311
            .:||.:|.|.|.....|:.|..:|.||.|:||..|.:.|.:.|.|..|.:.|.|::|.||.:|..
Human   312 PYKCEECGKAFRVFSILKKHKIIHTGEKPYKCEECGKAFNQFSNLTKHKIIHTGEKPYKCDECGK 376

  Fly   312 TFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLR 376
            .|...|....|.|:||.|:.|||.||.|:|.:.|.|.||:.:||||:|:||..|.|.|...:...
Human   377 AFNQSSTLTKHKRIHTGEKPYKCEECGKAFKQSSTLTEHKIIHTGEKPYKCEKCGKAFSWSSAFT 441

  Fly   377 VHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGE 441
            .|..:|:.:|..||..|.|.|.:.|.|..|...||.:..::|..|.|::..||....|...||..
Human   442 KHKRNHMEDKPYKCEECGKAFSVFSTLTKHKIIHTREKPYKCEECGKAFNQSSIFTKHKIIHTEG 506

  Fly   442 LPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRH 490
            ..:||..|...|.:|:........:|||||||...|...:.:.|:|..|
Human   507 KSYKCEKCGNAFNQSSNLTARKIIYTGEKPYKYEECDKAFNKFSTLITH 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	147/405 (36%)
		C2H2 Zn finger	84..104	CDD:275368	4/19 (21%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	9/19 (47%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	5/19 (26%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	4/19 (21%)
		C2H2 Zn finger	474..492	CDD:275368	4/17 (24%)
ZNF92	NP_689839.1	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	175..195	CDD:275368	5/19 (26%)
		C2H2 Zn finger	203..223	CDD:275368	7/19 (37%)
		zf-H2C2_2	216..240	CDD:290200	11/23 (48%)
		COG5048	227..579	CDD:227381	125/329 (38%)
		C2H2 Zn finger	231..251	CDD:275368	7/19 (37%)
		zf-H2C2_2	243..268	CDD:290200	10/24 (42%)
		C2H2 Zn finger	259..279	CDD:275368	9/19 (47%)
		zf-H2C2_2	272..296	CDD:290200	11/23 (48%)
		C2H2 Zn finger	287..307	CDD:275368	9/19 (47%)
		zf-H2C2_2	300..322	CDD:290200	9/21 (43%)
		C2H2 Zn finger	315..335	CDD:275368	6/19 (32%)
		zf-H2C2_2	328..352	CDD:290200	10/23 (43%)
		C2H2 Zn finger	343..363	CDD:275368	6/19 (32%)
		zf-H2C2_2	355..380	CDD:290200	9/24 (38%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		zf-H2C2_2	384..408	CDD:290200	12/23 (52%)
		C2H2 Zn finger	399..419	CDD:275368	9/19 (47%)
		zf-H2C2_2	412..435	CDD:290200	12/22 (55%)
		C2H2 Zn finger	427..447	CDD:275368	5/19 (26%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
		zf-H2C2_2	468..492	CDD:290200	7/23 (30%)
		C2H2 Zn finger	483..503	CDD:275368	6/19 (32%)
		C2H2 Zn finger	539..556	CDD:275368	4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810