Protein Alignment CG5245 and ZNF676

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: XP_054176068.1
• Gene: ZNF676 / 163223
• HGNCID: 20429
• Length: 704
• Species: Homo sapiens
• Alignment Length: 482
• Identity: 177/482 - (36%)
• Similarity: 251/482 - (52%)
• Gaps: 13/482 - (2%)

  Fly    22 EEELIFISNSDFEELESEIKIENFCS---YGKDLEPVKGVPSKLKTCK------SKIAKKRPLRK 77
            :.|.|:...:.: :.|...|..|:.|   |.|.:...: .|.|.:.|.      |.:.|.:.:..
Human   190 QHERIYTRENSY-KCEENGKAFNWSSTLTYYKSIHTGE-KPYKCEECGKAFSKFSILTKHKVIHT 252

  Fly    78 QTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHE-KRPHKCSH 141
            ....:||.:|.|.|.|...|..|..:|..|:|::|..|.|:|...::...|...|. ::|:||..
Human   253 GEKPYKCEECGKAFNRSSILTKHKIIHTGEKPYKCEECGKAFNSSSNLMEHKRVHTGEKPYKCEE 317

  Fly   142 CSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNS 206
            |.|.|:.:|||.:|...|.||:|:||.:|..:|.|.|.|..|...|:.|:|::|..|.|.|.:.|
Human   318 CGKAFSWSSSLTEHKRIHAGEKPYKCEECGKAFNRSSILTKHKIIHTGEKPYKCEECGKGFSSVS 382

  Fly   207 HLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVH 270
            .|..|...|.|.:|:||..|.|:....|.|.:|...| .|:.:||.:|.|.|..:.||..|.|:|
Human   383 TLNTHKAIHAEEKPYKCEECGKASNSSSKLMEHKRIHTGEKPYKCEECGKAFSWSSSLTEHKRIH 447

  Fly   271 AGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCA 335
            |||.|:||..|.:.|.|:|.|..|.:.|.|::|.||..|...|:..|....|..:|..|:.|||.
Human   448 AGEKPYKCEECGKAFNRSSILTKHKIIHTGEKPYKCEGCGKAFSKVSTLNTHKAIHAEEKPYKCE 512

  Fly   336 ECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLS 400
            ||.|:....|.|:||:::||||:|:||..|.|.|...:.|..|...|.|||..||..|.|.|..|
Human   513 ECGKASNSSSKLMEHKRIHTGEKPYKCEECGKAFSWSSSLTEHKRIHAGEKPYKCEECGKAFTWS 577

  Fly   401 SQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRT 465
            |....|.:.|..:..::|..|.|.::|.|.|..|...||||..:||..|.|.|:.|:...||...
Human   578 SSFTKHKRIHAAEKPYKCEECGKGFSTFSILTKHKIIHTGEKRYKCEECGKAFSWSSILTEHKII 642

  Fly   466 HTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            |||||||||..|...:::.|||.||.|
Human   643 HTGEKPYKCEECGKAFSRSSSLTRHKR 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	157/405 (39%)
		C2H2 Zn finger	84..104	CDD:275368	7/19 (37%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	7/17 (41%)
ZNF676	XP_054176068.1	KRAB	4..64	CDD:214630
		C2H2 Zn finger	146..167	CDD:275370
		C2H2 Zn finger	175..195	CDD:275368	1/4 (25%)
		C2H2 Zn finger	203..223	CDD:275368	6/19 (32%)
		C2H2 Zn finger	231..251	CDD:275368	3/19 (16%)
		COG5048	255..696	CDD:227381	164/415 (40%)
		C2H2 Zn finger	259..279	CDD:275368	7/19 (37%)
		C2H2 Zn finger	287..307	CDD:275368	5/19 (26%)
		C2H2 Zn finger	315..335	CDD:275368	8/19 (42%)
		C2H2 Zn finger	343..363	CDD:275368	7/19 (37%)
		C2H2 Zn finger	371..391	CDD:275368	7/19 (37%)
		C2H2 Zn finger	399..419	CDD:275368	6/19 (32%)
		C2H2 Zn finger	427..447	CDD:275368	8/19 (42%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
		C2H2 Zn finger	483..503	CDD:275368	5/19 (26%)
		C2H2 Zn finger	511..531	CDD:275368	8/19 (42%)
		C2H2 Zn finger	539..559	CDD:275368	6/19 (32%)
		C2H2 Zn finger	567..587	CDD:275368	7/19 (37%)
		C2H2 Zn finger	595..615	CDD:275368	7/19 (37%)
		C2H2 Zn finger	623..643	CDD:275368	7/19 (37%)
		C2H2 Zn finger	651..671	CDD:275368	8/19 (42%)
		C2H2 Zn finger	679..699	CDD:275368