DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF676

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001001411.2	Gene:	ZNF676 / 163223	HGNCID:	20429	Length:	588	Species:	Homo sapiens

Alignment Length:	548	Identity:	177/548 - (32%)
Similarity:	265/548 - (48%)	Gaps:	62/548 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NVDQRPVKDEPPQ---------------EDTFEEELI-FISNSDFEELESEIKIENF--CS---- 47
            |:.:..:.:|||.               ||:|::.:: .......|.|..:|...|.  |:
Human    32 NMKRHEMVEEPPVICSHFSQEFWPEQGIEDSFQKMILRRYDKCGHENLHLKISCTNVDECNVHKE 96

  Fly    48 -YGKDLEPVKGVPSKLKTC-------------------------------------KSKIAKKRP 74
             |.|..:.:....||:..|                                     .|.:::...
Human    97 GYNKLNQSLTTTQSKVFQCGKYANVFHKCSNSNRHKIRHTGEKGLKCKEYVRSFCMLSHLSQHER 161

  Fly    75 LRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHE-KRPHK 138
            :..:.:::||.:..|.|.....|..:..:|..|:|::|..|.|:|.:.:...:|.:.|. ::|:|
Human   162 IYTRENSYKCEENGKAFNWSSTLTYYKSIHTGEKPYKCEECGKAFSKFSILTKHKVIHTGEKPYK 226

  Fly   139 CSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFK 203
            |..|.|.|.::|.|.:|...||||:|:||.:|...|:..|.|..|...|:||:|::|..|.||..
Human   227 CEECGKAFNRSSILTKHKIIHTGEKPYKCEECGKGFSSVSTLNTHKAIHAEEKPYKCEECGKASN 291

  Fly   204 NNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHA-ERSFKCTQCPKTFLQNDSLQIHL 267
            ::|.|.||.|.|...:|:||..|.|:|...|.|.:|...|| |:.:||.:|.|.|.::..|..|.
Human   292 SSSKLMEHKRIHTGEKPYKCEECGKAFSWSSSLTEHKRIHAGEKPYKCEECGKAFNRSSILTKHK 356

  Fly   268 RVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQY 332
            .:|.||.|:||..|.:.|::.|.|..|...||.::|.||.:|.......|....|.|:||.|:.|
Human   357 IIHTGEKPYKCEGCGKAFSKVSTLNTHKAIHAEEKPYKCEECGKASNSSSKLMEHKRIHTGEKPY 421

  Fly   333 KCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEF 397
            ||.||.|:|...|.|.||:::|.||:|:||..|.|.|...:....|...|..||..||..|.|.|
Human   422 KCEECGKAFSWSSSLTEHKRIHAGEKPYKCEECGKAFTWSSSFTKHKRIHAAEKPYKCEECGKGF 486

  Fly   398 KLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEH 462
            ...|.|..|...|||:.:::|..|.|:::.||.|..|...||||.|:||..|.|.|:||:....|
Human   487 STFSILTKHKIIHTGEKRYKCEECGKAFSWSSILTEHKIIHTGEKPYKCEECGKAFSRSSSLTRH 551

  Fly   463 LRTHTGEKPYKCSHCSTRYTQKSSLGRH 490
            .|.|||||||||..|...:...|::..|
Human   552 KRIHTGEKPYKCEECGKAFKSSSTVSYH 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	156/405 (39%)
		C2H2 Zn finger	84..104	CDD:275368	4/19 (21%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	5/19 (26%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..492	CDD:275368	4/17 (24%)
ZNF676	NP_001001411.2	KRAB	<1..32	CDD:214630	177/548 (32%)
		C2H2 Zn finger	114..135	CDD:275370	1/20 (5%)
		C2H2 Zn finger	143..163	CDD:275368	1/19 (5%)
		C2H2 Zn finger	171..191	CDD:275368	4/19 (21%)
		COG5048	195..580	CDD:227381	152/385 (39%)
		C2H2 Zn finger	199..219	CDD:275368	5/19 (26%)
		zf-H2C2_2	212..236	CDD:290200	8/23 (35%)
		C2H2 Zn finger	227..247	CDD:275368	7/19 (37%)
		zf-H2C2_2	240..264	CDD:290200	11/23 (48%)
		C2H2 Zn finger	255..275	CDD:275368	6/19 (32%)
		C2H2 Zn finger	283..303	CDD:275368	9/19 (47%)
		zf-H2C2_2	296..319	CDD:290200	10/22 (45%)
		C2H2 Zn finger	311..331	CDD:275368	7/19 (37%)
		zf-H2C2_2	323..348	CDD:290200	10/24 (42%)
		C2H2 Zn finger	339..359	CDD:275368	6/19 (32%)
		zf-H2C2_2	352..375	CDD:290200	9/22 (41%)
		C2H2 Zn finger	367..387	CDD:275368	6/19 (32%)
		C2H2 Zn finger	395..415	CDD:275368	5/19 (26%)
		zf-H2C2_2	408..431	CDD:290200	11/22 (50%)
		C2H2 Zn finger	423..443	CDD:275368	9/19 (47%)
		zf-H2C2_2	435..459	CDD:290200	11/23 (48%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	479..499	CDD:275368	7/19 (37%)
		zf-H2C2_2	492..515	CDD:290200	8/22 (36%)
		C2H2 Zn finger	507..527	CDD:275368	7/19 (37%)
		zf-H2C2_2	520..544	CDD:290200	12/23 (52%)
		C2H2 Zn finger	535..555	CDD:275368	8/19 (42%)
		zf-H2C2_2	547..572	CDD:290200	12/24 (50%)
		C2H2 Zn finger	563..583	CDD:275368	4/17 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900