DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF567

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001374688.1	Gene:	ZNF567 / 163081	HGNCID:	28696	Length:	670	Species:	Homo sapiens

Alignment Length:	525	Identity:	184/525 - (35%)
Similarity:	275/525 - (52%)	Gaps:	49/525 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QRPV--KDEPPQEDTFEEEL-----IFISNSDFEELESEIKIENFCSYGKDLEPVKGVPSKLKTC 65
            :.||  |:.||:.||....|     :.|||.:    .:..::..:..|||.|     :.:|.:|.
Human   145 KNPVNSKNLPPEYDTHGRILKNVSELIISNLN----PARKRLSEYNGYGKSL-----LSTKQETT 200

  Fly    66 KSKIAKKRPLRK------------QTDT----FKCTQCQKTFTRKENLESHLRLHAEERP----- 109
            ..::.......:            :|:|    |....|:|:|.::..|.:|.|.:..|.|
Human   201 HPEVKSHNQSARAFSHNEVLMQYQKTETPAQSFGYNDCEKSFLQRGGLITHSRPYKGENPSVYNK 265

  Fly   110 ----------FECSHCSKSFGRRTHYKRHLLKH-EKRPHKCSHCSKTFTQNSSLKQHLHEHTGER 163
                      ..|:.|.|||.|::....|...| |::|::|..|...|.:.|.|..|...||||:
Human   266 KRRATNIEKKHTCNECGKSFCRKSVLILHQGIHSEEKPYQCHQCGNAFRRKSYLIDHQRTHTGEK 330

  Fly   164 PFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSK 228
            ||.|.:|..||..|:.|..|.|||:.|:.:||..|..||:..|||..|.|||...:|::|:.|.|
Human   331 PFVCNECGKSFRLKTALTDHQRTHTGEKSYECLQCRNAFRLKSHLIRHQRTHTGEKPYECNDCGK 395

  Fly   229 SFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQ 292
            ||:.::.|..|...| .|:.:.|.:|.|:|.|..:|.:|.|.|.||.|:.|..|.::|::.:.|.
Human   396 SFRQKTTLSLHQRIHTGEKPYICKECGKSFHQKANLTVHQRTHTGEKPYICNECGKSFSQKTTLA 460

  Fly   293 LHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGE 357
            ||...|..::|..||:|..:|..::....|.|.||.|:.|:|..|.|:|..||:|::|.:.||||
Human   461 LHEKTHNEEKPYICSECGKSFRQKTTLVAHQRTHTGEKSYECPHCGKAFRMKSYLIDHHRTHTGE 525

  Fly   358 RPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCS 422
            :|::|..|.|.|..:|:|.:|...|.|||...|:.|.|.|:..:.|.||.:.|||:..:|||.|.
Human   526 KPYECNECGKSFSQKTNLNLHQRIHTGEKPYVCNECGKSFRQKATLTVHQKIHTGQKSYECPQCG 590

  Fly   423 KSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSL 487
            |:::..|.|..|.||||||.|:|||.|.|.|.:......|.|||||||||.|:.|...::.|.:|
Human   591 KAFSRKSYLIHHQRTHTGEKPYKCSECGKCFRQKTNLIVHQRTHTGEKPYVCNECGKSFSYKRNL 655

  Fly   488 GRHLR 492
            ..|.|
Human   656 IVHQR 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	162/436 (37%)
		C2H2 Zn finger	84..104	CDD:275368	6/19 (32%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	6/19 (32%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	11/24 (46%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
ZNF567	NP_001374688.1	KRAB	6..89	CDD:214630
		C2H2 Zn finger	236..255	CDD:275368	6/18 (33%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		COG5048	302..650	CDD:227381	143/347 (41%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	9/19 (47%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..494	CDD:275368	6/19 (32%)
		C2H2 Zn finger	502..522	CDD:275368	8/19 (42%)
		C2H2 Zn finger	530..550	CDD:275368	7/19 (37%)
		C2H2 Zn finger	558..578	CDD:275368	7/19 (37%)
		C2H2 Zn finger	586..606	CDD:275368	8/19 (42%)
		C2H2 Zn finger	614..634	CDD:275368	7/19 (37%)
		zf-C2H2	640..662	CDD:395048	7/21 (33%)
		C2H2 Zn finger	642..662	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810