Protein Alignment CG5245 and ZNF497

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_940860.2
• Gene: ZNF497 / 162968
• HGNCID: 23714
• Length: 498
• Species: Homo sapiens
• Alignment Length: 455
• Identity: 167/455 - (36%)
• Similarity: 233/455 - (51%)
• Gaps: 44/455 - (9%)

  Fly    49 GKDLEPVKG---------VPSKLKTCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLH 104
            |::|.|..|         .|:      .:..:..||.::... :|.:|.|.|::...|..|.|:|
Human    71 GRELGPADGGRDGAGPRSEPA------DRALRPSPLPEEPGC-RCGECGKAFSQGSYLLQHRRVH 128

  Fly   105 AEERPFECSHCSKSFGRRTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCT 168
            ..|:|:.|..|.|:|...::..:|...|. ::|:.|..|.|.|..:|.|..|...|:|.:||:|.
Human   129 TGEKPYTCPECGKAFAWSSNLSQHQRIHSGEKPYACRECGKAFRAHSQLIHHQETHSGLKPFRCP 193

  Fly   169 QCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLR 233
            .|..||.|.:.|..|.|||:.|:|:||..|.|||..||:..||.|.|..|||
Human   194 DCGKSFGRSTTLVQHRRTHTGEKPYECPECGKAFSWNSNFLEHRRVHTGARP------------- 245

  Fly   234 SILQKHLLTHAERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEH 298
                     ||     |..|.|.|.|:.:|..||::|||..|..||.|.:.|.|.:.|:.|...|
Human   246 ---------HA-----CRDCGKAFSQSSNLAEHLKIHAGARPHACPDCGKAFVRVAGLRQHRRTH 296

  Fly   299 AGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCT 363
            :.::|..|::|...|...|....|.|.||.||.::||||.::|...|:|.||::|||||:|..|.
Human   297 SSEKPFPCAECGKAFRESSQLLQHQRTHTGERPFECAECGQAFVMGSYLAEHRRVHTGEKPHACA 361

  Fly   364 HCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTS 428
            .|.|.|..|::|..|...|.|.|...|:.|.|.|:.||.|..|...|||:..|.|..|.|::..|
Human   362 QCGKAFSQRSNLLSHRRTHSGAKPFACADCGKAFRGSSGLAHHRLSHTGERPFACAECGKAFRGS 426

  Fly   429 STLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLRR 493
            |.|..|.|.|:||.||.|:||||.|.|.:|...|.||||||:||.|..|...::.:.:|..|.:|
Human   427 SELRQHQRLHSGERPFVCAHCSKAFVRKSELLSHRRTHTGERPYACGECGKPFSHRCNLNEHQKR 491

  Fly   494  493
            Human   492  491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	158/404 (39%)
		C2H2 Zn finger	84..104	CDD:275368	7/19 (37%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		C2H2 Zn finger	195..215	CDD:275368	10/19 (53%)
		C2H2 Zn finger	223..243	CDD:275368	0/19 (0%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	10/19 (53%)
		C2H2 Zn finger	474..492	CDD:275368	4/17 (24%)
ZNF497	NP_940860.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..104		7/38 (18%)
		COG5048	107..492	CDD:227381	160/412 (39%)
		C2H2 Zn finger	108..128	CDD:275368	7/19 (37%)
		C2H2 Zn finger	136..156	CDD:275368	5/19 (26%)
		C2H2 Zn finger	164..184	CDD:275368	7/19 (37%)
		C2H2 Zn finger	192..212	CDD:275368	8/19 (42%)
		C2H2 Zn finger	220..240	CDD:275368	10/19 (53%)
		C2H2 Zn finger	248..268	CDD:275368	8/19 (42%)
		C2H2 Zn finger	276..296	CDD:275368	7/19 (37%)
		C2H2 Zn finger	304..324	CDD:275368	6/19 (32%)
		C2H2 Zn finger	332..352	CDD:275368	9/19 (47%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	388..408	CDD:275368	8/19 (42%)
		C2H2 Zn finger	416..436	CDD:275368	8/19 (42%)
		C2H2 Zn finger	444..464	CDD:275368	10/19 (53%)
		C2H2 Zn finger	472..492	CDD:275368	5/20 (25%)