DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF782

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001001662.1	Gene:	ZNF782 / 158431	HGNCID:	33110	Length:	699	Species:	Homo sapiens

Alignment Length:	511	Identity:	182/511 - (35%)
Similarity:	268/511 - (52%)	Gaps:	42/511 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VKDEPPQEDTFEEELIFISNSDFEELES------------------EIKIENFCSYGKDL--EPV 55
            ||....:|:..:.:.|.....|||..||                  :.|..||..:|::.  :..
Human   193 VKTLHHKEEVIQHQTIQTLGQDFEYNESRKAFLEKAALVTSNSTHPKGKSYNFNKFGENKYDKST 257

  Fly    56 KGVPSKLKTCKSKIAKKRPLRKQTDTFKCTQCQ---------KTFTRKENLESHLRLHAEERPFE 111
            ..:|..:...||..       :..||..|. |:         |:|::|.::..|.|:|...:|||
Human   258 FIIPQNMNPEKSHY-------EFNDTGNCF-CRITHKTLTGGKSFSQKSHIREHHRVHIGVKPFE 314

  Fly   112 CSHCSKSFGRRTHYKRHLLKHEKRPHKCSH-CSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFA 175
               ..|||.|.:....|...|....:...| |::||:..|:...|...|...:|::..:|..|.:
Human   315 ---YGKSFNRNSTLPVHQRTHATDKYSDYHPCTETFSYQSTFSVHQKVHIRAKPYEYNECGKSCS 376

  Fly   176 RKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHL 240
            ..|||....::|:.|:|:||..|.|||...|.|::|.|||...:|:||..|.|:|..:|.|:.|.
Human   377 MNSHLIWPQKSHTGEKPYECPECGKAFSEKSRLRKHQRTHTGEKPYKCDGCDKAFSAKSGLRIHQ 441

  Fly   241 LTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPL 304
            .|| .|:.|:|.:|.|:|.....|.:|.|.|.||.||:|..|.::|:..|.|:.|...|.|:.|.
Human   442 RTHTGEKPFECHECGKSFNYKSILIVHQRTHTGEKPFECNECGKSFSHMSGLRNHRRTHTGERPY 506

  Fly   305 KCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDF 369
            ||.:|...|.::|..|.|.|.||.|:.|||.:|.|:|.:||.|..|.::||||:|:||.||.:.|
Human   507 KCDECGKAFKLKSGLRKHHRTHTGEKPYKCNQCGKAFGQKSQLRGHHRIHTGEKPYKCNHCGEAF 571

  Fly   370 KCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMH 434
            ..:::||||...|.|||..:|..|.|.|:..|.|..|.:.|||:..:||..|.|:::..|.|..|
Human   572 SQKSNLRVHHRTHTGEKPYQCEECGKTFRQKSNLRGHQRTHTGEKPYECNECGKAFSEKSVLRKH 636

  Fly   435 LRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRH 490
            .||||||.|:.|:.|.:.|::.:..:.|.|||||||||||..|...::|||||..|
Human   637 QRTHTGEKPYNCNQCGEAFSQKSNLRVHQRTHTGEKPYKCDKCGRTFSQKSSLREH 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	159/414 (38%)
		C2H2 Zn finger	84..104	CDD:275368	7/28 (25%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	6/20 (30%)
		C2H2 Zn finger	167..187	CDD:275368	5/19 (26%)
		zf-H2C2_2	179..204	CDD:290200	11/24 (46%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	8/19 (42%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	5/19 (26%)
		C2H2 Zn finger	474..492	CDD:275368	8/17 (47%)
ZNF782	NP_001001662.1	KRAB	8..67	CDD:214630
		KRAB	8..47	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..95
		C2H2 Zn finger	291..307	CDD:275368	5/15 (33%)
		C2H2 Zn finger	314..332	CDD:275368	6/20 (30%)
		C2H2 Zn finger	343..360	CDD:275368	5/16 (31%)
		C2H2 Zn finger	369..388	CDD:275368	5/18 (28%)
		COG5048	392..697	CDD:227381	132/301 (44%)
		C2H2 Zn finger	396..416	CDD:275368	9/19 (47%)
		zf-H2C2_2	409..432	CDD:290200	10/22 (45%)
		C2H2 Zn finger	424..444	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..461	CDD:290200	10/23 (43%)
		C2H2 Zn finger	452..472	CDD:275368	7/19 (37%)
		zf-H2C2_2	465..489	CDD:290200	11/23 (48%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		zf-H2C2_2	493..516	CDD:290200	8/22 (36%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		zf-H2C2_2	521..543	CDD:290200	11/21 (52%)
		C2H2 Zn finger	536..556	CDD:275368	8/19 (42%)
		zf-H2C2_2	549..573	CDD:290200	12/23 (52%)
		C2H2 Zn finger	564..584	CDD:275368	8/19 (42%)
		zf-H2C2_2	576..601	CDD:290200	12/24 (50%)
		C2H2 Zn finger	592..612	CDD:275368	7/19 (37%)
		zf-H2C2_2	604..628	CDD:290200	9/23 (39%)
		C2H2 Zn finger	620..640	CDD:275368	7/19 (37%)
		zf-H2C2_2	633..657	CDD:290200	12/23 (52%)
		C2H2 Zn finger	648..668	CDD:275368	5/19 (26%)
		zf-H2C2_2	660..685	CDD:290200	13/24 (54%)
		C2H2 Zn finger	676..696	CDD:275368	8/17 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900