DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF570

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001287922.1	Gene:	ZNF570 / 148268	HGNCID:	26416	Length:	592	Species:	Homo sapiens

Alignment Length:	492	Identity:	162/492 - (32%)
Similarity:	239/492 - (48%)	Gaps:	87/492 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PQEDTFEE-------ELIFISNSDFEELESEIKIENFCSYGKDLEPVKGVPSKLKTC--KSKIAK 71
            |::|.:||       |.:...|.::..|..|.|.|.:         .:..|...|.|  :..|..
Human   154 PKQDFYEEHQSQKIIETLTSYNLEYSSLREEWKCEGY---------FERQPGNQKACFKEEIITH 209

  Fly    72 KRPL---RKQ---------TDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTH 124
            :.||   |:|         .:...||  ||...::|.:..|   ..::|.|
Human   210 EEPLFDEREQEYKSWGSFHQNPLLCT--QKIIPKEEKVHKH---DTQKRSF-------------- 255

  Fly   125 YKRHLLK-------HEKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQV 182
             |::|:.       .||:..||:.|.|.|:|:|||..|...||||:|:||.:|..:|:::|:|..
Human   256 -KKNLMAIKPKSVCAEKKLLKCNDCEKVFSQSSSLTLHQRIHTGEKPYKCIECGKAFSQRSNLVQ 319

  Fly   183 HLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHAERS 247
            |.|.|:.|:|:||..|.|||..|:||.:|||.|...:|::|..|.|:|...:.|.:
Human   320 HQRIHTGEKPYECKECRKAFSQNAHLVQHLRVHTGEKPYECKVCRKAFSQFAYLAQ--------- 375

  Fly   248 FKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSAT 312
                              |.|||.||.|::|..|.:.|:..|.:..|...|.|::|.:|:.|...
Human   376 ------------------HQRVHTGEKPYECIECGKAFSNRSSIAQHQRVHTGEKPYECNVCGKA 422

  Fly   313 FAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRV 377
            |::|:...||.|:||.||.|:|.||.|:|.:.|||.:||::||||:|:||..|.|.|....:|..
Human   423 FSLRAYLTVHQRIHTGERPYECKECGKAFSQNSHLAQHQRIHTGEKPYKCQECRKAFSQIAYLAQ 487

  Fly   378 HMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGEL 442
            |...|.|||..:|..|.|.|...|.|..|.:.|||:..:||..|.|:::...:|..|.|.||||.
Human   488 HQRVHTGEKPYECIECGKAFSNDSSLTQHQRVHTGEKPYECTVCGKAFSYCGSLAQHQRIHTGER 552

  Fly   443 PFKCSHCSKLFARSAEHQEHLRTHTGEK---PYKCSH 476
            |::|..|.|.|.:.|....|.|.|.||.   |...:|
Human   553 PYECKECKKTFRQHAHLAHHQRIHIGESLSPPNPVNH 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	148/425 (35%)
		C2H2 Zn finger	84..104	CDD:275368	6/19 (32%)
		C2H2 Zn finger	112..132	CDD:275368	2/26 (8%)
		C2H2 Zn finger	139..159	CDD:275368	9/19 (47%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	11/19 (58%)
		C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	250..270	CDD:275368	2/19 (11%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	1/3 (33%)
ZNF570	NP_001287922.1	KRAB	70..130	CDD:214630
		C2H2 Zn finger	276..296	CDD:275368	9/19 (47%)
		zf-H2C2_2	288..313	CDD:316026	12/24 (50%)
		C2H2 Zn finger	304..324	CDD:275368	7/19 (37%)
		COG5048	<307..572	CDD:227381	108/291 (37%)
		C2H2 Zn finger	332..352	CDD:275368	11/19 (58%)
		C2H2 Zn finger	360..380	CDD:275368	7/46 (15%)
		C2H2 Zn finger	388..408	CDD:275368	5/19 (26%)
		C2H2 Zn finger	416..436	CDD:275368	7/19 (37%)
		C2H2 Zn finger	444..464	CDD:275368	10/19 (53%)
		C2H2 Zn finger	472..492	CDD:275368	6/19 (32%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		C2H2 Zn finger	528..548	CDD:275368	6/19 (32%)
		C2H2 Zn finger	556..576	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900