DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF714

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_872321.2	Gene:	ZNF714 / 148206	HGNCID:	27124	Length:	555	Species:	Homo sapiens

Alignment Length:	502	Identity:	173/502 - (34%)
Similarity:	241/502 - (48%)	Gaps:	62/502 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VDQRP------VKDEPPQE---DTFEEELIFISNSDFEELESEIKIENFCSYGKDLEPVKGVPSK 61
            ||:.|      .:|..|::   |:|::.:              ::....|.: ::|:..||   .
Human    43 VDESPAMCSSFTRDLWPEQDIKDSFQQVI--------------LRRHGKCEH-ENLQLRKG---S 89

  Fly    62 LKTCKSKIAKK--RPLRK-----QTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSF 119
            ....:.|:.||  ..|.:     |:..|.|.:..|.|.:..|...|...|..|:||:|..|.:||
Human    90 ANVVECKVYKKGYNELNQCLTTTQSKIFPCDKYIKVFHKIFNSNRHKTRHTGEKPFKCKKCDESF 154

  Fly   120 GRRTHYKRHLLKH-EKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVH 183
            ....|..:|...| .:..::|..|.|.|.:.|:|.:|...||||:||||.:|..:|...|.|..|
Human   155 CMLLHLHQHKRIHIRENSYQCEECDKVFKRFSTLTRHKRVHTGEKPFKCEECGKAFKHSSTLTTH 219

  Fly   184 LRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHAERSF 248
            ...|:.|:|:.|..|.|||.::|||..|...|...:||||..|.|:|...|.|..|..
Human   220 KMIHTGEKPYRCEECGKAFYHSSHLTTHKVIHTGEKPFKCEECGKAFNHPSALTTHKF------- 277

  Fly   249 KCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATF 313
                                :|..|.|:||..|.:.|.|.|.|..|.:.|:|::..||.||...|
Human   278 --------------------IHVKEKPYKCEECDKAFNRFSYLTKHKIIHSGEKSYKCEQCGKGF 322

  Fly   314 AMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVH 378
            ...|....|.|:||.|:.|||.||.|:|...|||..|:.:||||:|:||..|.|.|...:.|.:|
Human   323 NWSSTLTKHKRIHTGEKPYKCEECGKAFNVSSHLTTHKMIHTGEKPYKCEECGKAFNHSSKLTIH 387

  Fly   379 MLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELP 443
            .:.|.|||..||..|.|.|..||.|..|...|||:..::|..|.|::..||.|..|.|.||||.|
Human   388 KIIHTGEKPYKCEECGKAFNQSSNLTKHKIIHTGEKLYKCEECGKAFNRSSNLTTHKRIHTGEKP 452

  Fly   444 FKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRH 490
            :||..|.|.|.||:...:|...|||||.|||..|...:.|.|:|.:|
Human   453 YKCEECGKAFNRSSNLTKHNIIHTGEKSYKCEECGKAFNQSSTLTKH 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	154/409 (38%)
		C2H2 Zn finger	84..104	CDD:275368	5/19 (26%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	0/19 (0%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
ZNF714	NP_872321.2	KRAB	<2..36	CDD:214630
		C2H2 Zn finger	147..167	CDD:275368	6/19 (32%)
		COG5048	171..504	CDD:227381	140/356 (39%)
		C2H2 Zn finger	175..195	CDD:275368	7/19 (37%)
		zf-H2C2_2	188..212	CDD:290200	12/23 (52%)
		C2H2 Zn finger	203..223	CDD:275368	6/19 (32%)
		C2H2 Zn finger	231..251	CDD:275368	9/19 (47%)
		zf-H2C2_2	243..268	CDD:290200	11/24 (46%)
		C2H2 Zn finger	259..279	CDD:275368	7/46 (15%)
		C2H2 Zn finger	287..307	CDD:275368	7/19 (37%)
		C2H2 Zn finger	315..335	CDD:275368	7/19 (37%)
		zf-H2C2_2	328..351	CDD:290200	11/22 (50%)
		C2H2 Zn finger	343..363	CDD:275368	9/19 (47%)
		zf-H2C2_2	355..380	CDD:290200	13/24 (54%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		zf-H2C2_2	384..408	CDD:290200	11/23 (48%)
		C2H2 Zn finger	399..419	CDD:275368	8/19 (42%)
		zf-H2C2_2	411..436	CDD:290200	8/24 (33%)
		C2H2 Zn finger	427..447	CDD:275368	8/19 (42%)
		zf-H2C2_2	439..464	CDD:290200	13/24 (54%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
		zf-H2C2_2	467..492	CDD:290200	10/24 (42%)
		C2H2 Zn finger	483..502	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900