DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF583

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_005258615.1	Gene:	ZNF583 / 147949	HGNCID:	26427	Length:	570	Species:	Homo sapiens

Alignment Length:	519	Identity:	174/519 - (33%)
Similarity:	245/519 - (47%)	Gaps:	82/519 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VKDEPPQEDTFEEELIFISNSDF----EELESEIKI----ENFCSYGKDLEPVKGVPSKLKTCKS 67
            ||.|..:....:.|.:| .||:|    |..|...|:    ....||..|      .||..:.|:|
Human    68 VKKEGTRGPCPDWEYVF-KNSEFSSKQETYEESSKVVTVGARHLSYSLD------YPSLREDCQS 125

  Fly    68 KIAKKRPL--------------------------RKQTDTF---KCTQCQKTFTRKENLESHLRL 103
            :...|..|                          .|...||   .....|::|..||....|
Human   126 EDWYKNQLGSQEVHLSQLIITHKEILPEVQNKEYNKSWQTFHQDTIFDIQQSFPTKEKAHKH--- 187

  Fly   104 HAEERPFECSHCSKSFGRRTHYKRHLLKHEKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCT 168
                .|.:.|:..||...: |.|.::   ||:..||:.|.|.|.|:|||..|...||||:|:.|.
Human   188 ----EPQKKSYRKKSVEMK-HRKVYV---EKKLLKCNDCEKVFNQSSSLTLHQRIHTGEKPYACV 244

  Fly   169 QCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLR 233
            :|..:|::.::|..|.|.|:.|:|:||..|.|||..|:||.:|.|.|...:|::|..|.|:|.
Human   245 ECGKTFSQSANLAQHKRIHTGEKPYECKECRKAFSQNAHLAQHQRVHTGEKPYQCKECKKAFS-- 307

  Fly   234 SILQKHLLTHAERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEH 298
                                     |...|..|.|||.||.||:|..|.:.|:..|.|..|...|
Human   308 -------------------------QIAHLTQHQRVHTGERPFECIECGKAFSNGSFLAQHQRIH 347

  Fly   299 AGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCT 363
            .|::|..|:.|...|:.|....||.|:||.||.|:|.||.|:|.:.:||.:||:|||||:|::|.
Human   348 TGEKPYVCNVCGKAFSHRGYLIVHQRIHTGERPYECKECRKAFSQYAHLAQHQRVHTGEKPYECK 412

  Fly   364 HCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTS 428
            .|.|.|....:|..|...|.|||..:|..|.|.|..||.|..|.:.|||:..:.|..|.|:::.:
Human   413 VCRKAFSQIAYLDQHQRVHTGEKPYECIECGKAFSNSSSLAQHQRSHTGEKPYMCKECRKTFSQN 477

  Fly   429 STLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            :.|..|.|.||||.|::|:.|.|.|:.|.....|.|.||||:||:|..|...:.|::.|..|.|
Human   478 AGLAQHQRIHTGEKPYECNVCGKAFSYSGSLTLHQRIHTGERPYECKDCRKSFRQRAHLAHHER 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	150/432 (35%)
		C2H2 Zn finger	84..104	CDD:275368	5/19 (26%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	9/19 (47%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	10/19 (53%)
		C2H2 Zn finger	223..243	CDD:275368	4/19 (21%)
		C2H2 Zn finger	250..270	CDD:275368	4/19 (21%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
ZNF583	XP_005258615.1	C2H2 Zn finger	355..375	CDD:275368	7/19 (37%)
		zf-H2C2_2	367..392	CDD:290200	13/24 (54%)
		C2H2 Zn finger	383..403	CDD:275368	9/19 (47%)
		zf-H2C2_2	395..420	CDD:290200	14/24 (58%)
		C2H2 Zn finger	411..431	CDD:275368	6/19 (32%)
		zf-H2C2_2	423..448	CDD:290200	10/24 (42%)
		C2H2 Zn finger	439..459	CDD:275368	8/19 (42%)
		zf-H2C2_2	451..476	CDD:290200	8/24 (33%)
		C2H2 Zn finger	467..487	CDD:275368	6/19 (32%)
		zf-H2C2_2	480..504	CDD:290200	12/23 (52%)
		C2H2 Zn finger	495..515	CDD:275368	7/19 (37%)
		zf-H2C2_2	507..532	CDD:290200	10/24 (42%)
		C2H2 Zn finger	523..543	CDD:275368	6/19 (32%)
		KRAB	7..67	CDD:214630
		KRAB	7..46	CDD:279668
		COG5048	210..543	CDD:227381	139/359 (39%)
		C2H2 Zn finger	215..235	CDD:275368	9/19 (47%)
		zf-H2C2_2	227..252	CDD:290200	11/24 (46%)
		C2H2 Zn finger	243..263	CDD:275368	6/19 (32%)
		zf-H2C2_2	255..280	CDD:290200	12/24 (50%)
		C2H2 Zn finger	271..291	CDD:275368	10/19 (53%)
		zf-H2C2_2	283..308	CDD:290200	10/51 (20%)
		C2H2 Zn finger	299..319	CDD:275368	8/46 (17%)
		zf-H2C2_2	311..336	CDD:290200	12/24 (50%)
		C2H2 Zn finger	327..347	CDD:275368	6/19 (32%)
		zf-H2C2_2	340..364	CDD:290200	8/23 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900