Protein Alignment CG5245 and ZNF583

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: XP_005258615.1
• Gene: ZNF583 / 147949
• HGNCID: 26427
• Length: 570
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 174/519 - (33%)
• Similarity: 245/519 - (47%)
• Gaps: 82/519 - (15%)

  Fly    11 VKDEPPQEDTFEEELIFISNSDF----EELESEIKI----ENFCSYGKDLEPVKGVPSKLKTCKS 67
            ||.|..:....:.|.:| .||:|    |..|...|:    ....||..|      .||..:.|:|
Human    68 VKKEGTRGPCPDWEYVF-KNSEFSSKQETYEESSKVVTVGARHLSYSLD------YPSLREDCQS 125

  Fly    68 KIAKKRPL--------------------------RKQTDTF---KCTQCQKTFTRKENLESHLRL 103
            :...|..|                          .|...||   .....|::|..||....|
Human   126 EDWYKNQLGSQEVHLSQLIITHKEILPEVQNKEYNKSWQTFHQDTIFDIQQSFPTKEKAHKH--- 187

  Fly   104 HAEERPFECSHCSKSFGRRTHYKRHLLKHEKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCT 168
                .|.:.|:..||...: |.|.::   ||:..||:.|.|.|.|:|||..|...||||:|:.|.
Human   188 ----EPQKKSYRKKSVEMK-HRKVYV---EKKLLKCNDCEKVFNQSSSLTLHQRIHTGEKPYACV 244

  Fly   169 QCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLR 233
            :|..:|::.::|..|.|.|:.|:|:||..|.|||..|:||.:|.|.|...:|::|..|.|:|.
Human   245 ECGKTFSQSANLAQHKRIHTGEKPYECKECRKAFSQNAHLAQHQRVHTGEKPYQCKECKKAFS-- 307

  Fly   234 SILQKHLLTHAERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEH 298
                                     |...|..|.|||.||.||:|..|.:.|:..|.|..|...|
Human   308 -------------------------QIAHLTQHQRVHTGERPFECIECGKAFSNGSFLAQHQRIH 347

  Fly   299 AGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCT 363
            .|::|..|:.|...|:.|....||.|:||.||.|:|.||.|:|.:.:||.:||:|||||:|::|.
Human   348 TGEKPYVCNVCGKAFSHRGYLIVHQRIHTGERPYECKECRKAFSQYAHLAQHQRVHTGEKPYECK 412

  Fly   364 HCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTS 428
            .|.|.|....:|..|...|.|||..:|..|.|.|..||.|..|.:.|||:..:.|..|.|:::.:
Human   413 VCRKAFSQIAYLDQHQRVHTGEKPYECIECGKAFSNSSSLAQHQRSHTGEKPYMCKECRKTFSQN 477

  Fly   429 STLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            :.|..|.|.||||.|::|:.|.|.|:.|.....|.|.||||:||:|..|...:.|::.|..|.|
Human   478 AGLAQHQRIHTGEKPYECNVCGKAFSYSGSLTLHQRIHTGERPYECKDCRKSFRQRAHLAHHER 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	150/432 (35%)
		C2H2 Zn finger	84..104	CDD:275368	5/19 (26%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	9/19 (47%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		C2H2 Zn finger	195..215	CDD:275368	10/19 (53%)
		C2H2 Zn finger	223..243	CDD:275368	4/19 (21%)
		C2H2 Zn finger	250..270	CDD:275368	4/19 (21%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
ZNF583	XP_005258615.1	KRAB	7..67	CDD:214630
		COG5048	210..543	CDD:227381	139/359 (39%)
		C2H2 Zn finger	215..235	CDD:275368	9/19 (47%)
		C2H2 Zn finger	243..263	CDD:275368	6/19 (32%)
		C2H2 Zn finger	271..291	CDD:275368	10/19 (53%)
		C2H2 Zn finger	299..319	CDD:275368	8/46 (17%)
		C2H2 Zn finger	327..347	CDD:275368	6/19 (32%)
		C2H2 Zn finger	355..375	CDD:275368	7/19 (37%)
		C2H2 Zn finger	383..403	CDD:275368	9/19 (47%)
		C2H2 Zn finger	411..431	CDD:275368	6/19 (32%)
		C2H2 Zn finger	439..459	CDD:275368	8/19 (42%)
		C2H2 Zn finger	467..487	CDD:275368	6/19 (32%)
		C2H2 Zn finger	495..515	CDD:275368	7/19 (37%)
		C2H2 Zn finger	523..543	CDD:275368	6/19 (32%)