DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF563

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_660319.1	Gene:	ZNF563 / 147837	HGNCID:	30498	Length:	476	Species:	Homo sapiens

Alignment Length:	403	Identity:	129/403 - (32%)
Similarity:	196/403 - (48%)	Gaps:	42/403 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 DTFKCTQCQKTFTRKENLESHLRLHAEERPFECS------HCSKSFGRRTHYKRHLLKHEKRPH- 137
            |..:..:|::......:|.||:|:.:..:|.|..      |..|..|:...| .|..:...|||
Human   101 DPCQSAECEEVIMGHLSLNSHIRVDSGHKPHEYQEYGEKPHTHKQRGKAFSY-HHSFQSRGRPHT 164

  Fly   138 -----KCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTH 197
                 :|..|.|||:...:|::|:....|.||:||..|..:|...|.|::|.|||:.|:|:||..
Human   165 GKKRYECKECGKTFSSRRNLRRHMVVQGGNRPYKCKLCGKAFFWPSLLRMHERTHTGEKPYECKQ 229

  Fly   198 CEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHAERSFKCTQCPKTFLQNDS 262
            |.|||...|..:.|.|.|...:|::|..|||:                            |.:.|
Human   230 CSKAFPFYSSYRRHERMHTGEKPYECKQCSKA----------------------------LPDSS 266

  Fly   263 LQI-HLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLH 326
            ..| |.|.|.||.|:.|..|.:.|:.:|.|:.|...|:.::|.:|.||..||.....:::|::.|
Human   267 SYIRHERTHTGEKPYTCKQCGKAFSVSSSLRRHETTHSAEKPYECKQCGKTFHHLGSFQIHMKRH 331

  Fly   327 TRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCS 391
            |.:|.:||..|.|.|.:.|.:..|:::||||:|::|..|.|.....:..|.||:.|.|....||.
Human   332 TGDRPHKCKICGKGFDRPSLVRYHERIHTGEKPYECKQCGKTLSHSSSFRRHMIMHTGGGPHKCK 396

  Fly   392 YCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARS 456
            .|.|.|...|....|.:.|:|:..:||..|.|:.:.||:...|:..|||:.|.||..|.|.|...
Human   397 ICGKAFVYPSVCQRHEKSHSGEKPYECKQCGKALSHSSSFRRHMVMHTGDGPNKCKVCGKAFVYP 461

  Fly   457 AEHQEHLRTHTGE 469
            :..|.|.:||..|
Human   462 SVCQRHEKTHWRE 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	129/403 (32%)
		C2H2 Zn finger	84..104	CDD:275368	5/19 (26%)
		C2H2 Zn finger	112..132	CDD:275368	5/25 (20%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	13/24 (54%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	4/19 (21%)
		C2H2 Zn finger	250..270	CDD:275368	5/20 (25%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	6/19 (32%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368
ZNF563	NP_660319.1	KRAB	4..40	CDD:307490
		C2H2 Zn finger	147..163	CDD:275368	4/16 (25%)
		C2H2 Zn finger	171..191	CDD:275368	7/19 (37%)
		COG5048	194..>472	CDD:227381	103/305 (34%)
		C2H2 Zn finger	199..219	CDD:275368	7/19 (37%)
		C2H2 Zn finger	227..247	CDD:275368	8/19 (42%)
		C2H2 Zn finger	255..275	CDD:275368	9/47 (19%)
		C2H2 Zn finger	283..303	CDD:275368	6/19 (32%)
		C2H2 Zn finger	311..331	CDD:275368	6/19 (32%)
		C2H2 Zn finger	339..359	CDD:275368	6/19 (32%)
		C2H2 Zn finger	367..387	CDD:275368	6/19 (32%)
		C2H2 Zn finger	395..415	CDD:275368	6/19 (32%)
		C2H2 Zn finger	423..443	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900