DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF578

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001093164.1	Gene:	ZNF578 / 147660	HGNCID:	26449	Length:	590	Species:	Homo sapiens

Alignment Length:	487	Identity:	160/487 - (32%)
Similarity:	232/487 - (47%)	Gaps:	68/487 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DLANVDQRPVKDE--------PPQEDTFEEELIFISNSDFEELESEIKIENFCSYGKDLEPVKGV 58
            |..:...:|:||:        .|:...|:.|         |::.::::
Human   143 DQRHAGNKPIKDQLGLSFHLHLPELHIFQPE---------EKIANQVE----------------- 181

  Fly    59 PSKLKTCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRT 123
              |.....|.|:..:.:..:.:|.........|.....|.....:|..|:.|:|:...::|...:
Human   182 --KSVNDASSISTSQRISCRPETHTPNNYGNNFFHSSLLTQKQEVHMREKSFQCNETGEAFNCSS 244

  Fly   124 HYKRHLLKH--EKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRT 186
            ..::|.:.|  ||: :|...|.|.|.:...|.:|...||.|:|:||.:|..||:.||.|..|.|.
Human   245 FVRKHQIIHLGEKQ-YKFDICGKVFNEKRYLARHRRCHTSEKPYKCNECGKSFSYKSSLTCHRRC 308

  Fly   187 HSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHAE-RSFKC 250
            |:.|:|::|..|.|:|...|.|..|.|.|...:|:||:.|.|||..:|.|:.|...|.. :.:||
Human   309 HTGEKPYKCNECGKSFSYKSSLTCHHRCHTGEKPYKCNECGKSFSYKSSLRCHRRLHTGIKPYKC 373

  Fly   251 TQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAM 315
            .:|.|.|.||.:|.||..:|.||.|:||..|.:.|.:.|.|..|...|.|::|.||:.|...|..
Human   374 NECGKMFGQNSTLVIHKAIHTGEKPYKCNECGKAFNQQSHLSRHHRLHTGEKPYKCNDCGKAFIH 438

  Fly   316 RSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHML 380
            :|....|.||||.|:.|||.||.:.|.:||:|..|:.:||||:|:||..|.|.|..|:.|..|..
Human   439 QSSLARHHRLHTGEKSYKCEECDRVFSQKSNLERHKIIHTGEKPYKCNECHKTFSHRSSLPCHRR 503

  Fly   381 DHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFK 445
            .|.|||..||:.|.|.|.:.|    ||..|                       | |.||||.|:|
Human   504 LHSGEKPYKCNECGKTFNVQS----HLSRH-----------------------H-RLHTGEKPYK 540

  Fly   446 CSHCSKLFARSAEHQEHLRTHTGEKPYKCSHC 477
            |..|.|.|...:....|.|.|:|||||||:.|
Human   541 CKVCDKAFMCHSYLANHTRIHSGEKPYKCNEC 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	149/407 (37%)
		C2H2 Zn finger	84..104	CDD:275368	2/19 (11%)
		C2H2 Zn finger	112..132	CDD:275368	3/19 (16%)
		C2H2 Zn finger	139..159	CDD:275368	5/19 (26%)
		C2H2 Zn finger	167..187	CDD:275368	9/19 (47%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	2/19 (11%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	2/4 (50%)
ZNF578	NP_001093164.1	KRAB	24..64	CDD:307490
		C2H2 Zn finger	233..253	CDD:275368	3/19 (16%)
		COG5048	257..>582	CDD:227381	138/345 (40%)
		C2H2 Zn finger	262..281	CDD:275368	5/18 (28%)
		C2H2 Zn finger	289..309	CDD:275368	9/19 (47%)
		C2H2 Zn finger	317..337	CDD:275368	8/19 (42%)
		C2H2 Zn finger	345..365	CDD:275368	8/19 (42%)
		C2H2 Zn finger	373..393	CDD:275368	9/19 (47%)
		C2H2 Zn finger	401..421	CDD:275368	6/19 (32%)
		C2H2 Zn finger	429..449	CDD:275368	6/19 (32%)
		C2H2 Zn finger	457..477	CDD:275368	8/19 (42%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		C2H2 Zn finger	513..533	CDD:275368	10/47 (21%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900