DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF534

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001137411.1	Gene:	ZNF534 / 147658	HGNCID:	26337	Length:	674	Species:	Homo sapiens

Alignment Length:	441	Identity:	161/441 - (36%)
Similarity:	243/441 - (55%)	Gaps:	3/441 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 KLKTCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHY 125
            |:....|.:..::.:.....|:||:.|.:.|:...|...|.|:|..|:|::.:.|.|.|.:.:|.
Human   206 KVFRVSSSLTNRQVIHIADKTYKCSDCGEIFSSNSNFAQHQRIHTGEKPYKYNECGKVFNQNSHL 270

  Fly   126 KRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSE 189
            .:|...|. ::|:....|.|.|:.::.|.||...||||:|:||::|..:|:..|.|..||..|:.
Human   271 AQHQKIHTGQKPYNNKECGKVFSHHAYLAQHRKIHTGEKPYKCSECGKAFSVCSSLTAHLVIHTG 335

  Fly   190 ERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQC 253
            |:|::|..|.|.|::.|.|..|...|...||:||:.|.|.|...:.|.:|...| .|:.:||.:|
Human   336 EKPYDCKECGKVFRHKSSLTTHQTVHTGERPYKCNECGKGFSRIAFLARHRKVHTGEKPYKCNEC 400

  Fly   254 PKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSL 318
            .|.|:.|..|..|.::|.|...:||..|.:.|...|.|..|||.|.|::|.:|..|...|..:|.
Human   401 GKVFIGNSRLARHRKIHTGGRRYKCNECGKAFRTCSDLTAHLLIHTGEKPYECIDCGKVFRHKSS 465

  Fly   319 YRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHI 383
            ...|.|:||.|:.|||.||.|.|.:.|:|..|:::||||:.:||..|.|.|:..:||..|...|.
Human   466 LTYHCRIHTGEKPYKCNECGKVFSQNSNLQRHRKIHTGEKLYKCNECGKVFRQNSHLAQHRDIHT 530

  Fly   384 GEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSH 448
            |||...|:.|.|.|:.:|.|:.|...|||:..:.|..|.|.::.:|.|..|...||||.|..|:.
Human   531 GEKPYSCNECGKVFRRNSHLVRHRNVHTGEKPYSCNECGKVFSRNSHLARHRNIHTGEKPHSCNE 595

  Fly   449 CSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLRRTLCGTK 499
            |.|:|:|::....|.:.|||||.|||:.||..:::.|.|.:| |....|.|
Human   596 CGKVFSRNSHLARHRKIHTGEKLYKCNECSKVFSRNSRLAQH-RNIHTGVK 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	151/405 (37%)
		C2H2 Zn finger	84..104	CDD:275368	6/19 (32%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	6/19 (32%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	8/19 (42%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
ZNF534	NP_001137411.1	KRAB	8..81	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	201..221	CDD:275368	2/14 (14%)
		COG5048	211..609	CDD:227381	143/397 (36%)
		C2H2 Zn finger	229..249	CDD:275368	6/19 (32%)
		zf-H2C2_2	241..266	CDD:290200	9/24 (38%)
		C2H2 Zn finger	258..277	CDD:275368	5/18 (28%)
		C2H2 Zn finger	286..305	CDD:275368	6/18 (33%)
		zf-H2C2_2	297..321	CDD:290200	11/23 (48%)
		C2H2 Zn finger	313..333	CDD:275368	7/19 (37%)
		C2H2 Zn finger	341..361	CDD:275368	7/19 (37%)
		zf-H2C2_2	353..378	CDD:290200	10/24 (42%)
		C2H2 Zn finger	369..389	CDD:275368	6/19 (32%)
		zf-H2C2_2	382..404	CDD:290200	8/21 (38%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		C2H2 Zn finger	425..445	CDD:275368	8/19 (42%)
		C2H2 Zn finger	453..473	CDD:275368	6/19 (32%)
		zf-H2C2_2	465..490	CDD:290200	12/24 (50%)
		C2H2 Zn finger	481..501	CDD:275368	8/19 (42%)
		zf-H2C2_2	493..518	CDD:290200	11/24 (46%)
		C2H2 Zn finger	509..529	CDD:275368	7/19 (37%)
		zf-H2C2_2	521..546	CDD:290200	11/24 (46%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		zf-H2C2_2	549..574	CDD:290200	8/24 (33%)
		C2H2 Zn finger	565..585	CDD:275368	6/19 (32%)
		zf-H2C2_2	577..602	CDD:290200	11/24 (46%)
		C2H2 Zn finger	593..613	CDD:275368	6/19 (32%)
		zf-H2C2_2	605..630	CDD:290200	11/24 (46%)
		C2H2 Zn finger	621..641	CDD:275368	7/20 (35%)
		C2H2 Zn finger	649..669	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810