Protein Alignment CG5245 and ZFP28

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_065879.1
• Gene: ZFP28 / 140612
• HGNCID: 17801
• Length: 868
• Species: Homo sapiens
• Alignment Length: 497
• Identity: 175/497 - (35%)
• Similarity: 266/497 - (53%)
• Gaps: 37/497 - (7%)

  Fly    17 QEDTFEEELIFISNSDFEELE--------------SEIKIENFCSYGKDLEPVKGVPSKLKTCKS 67
            ||..|.:|.|..:.:..:|.|              ||.|:.|       .:.:|....     .|
Human   353 QETQFRQEPITHNKTLSKERERTYNKSGRWFYLDDSEEKVHN-------RDSIKNFQK-----SS 405

  Fly    68 KIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKH 132
            .:.|:..:......|||.:|:||||:..:|..|.|:|..|:|::|:.|.|:|...:.:.||...|
Human   406 VVIKQTGIYAGKKLFKCNECKKTFTQSSSLTVHQRIHTGEKPYKCNECGKAFSDGSSFARHQRCH 470

  Fly   133 E-KRPHKCSHCSKTFTQNSSLKQH-LHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFEC 195
            . |:|::|..|.|.|.||:||.:| .:.||||:||.|..|..:|:....|..|.|.|:.|:|::|
Human   471 TGKKPYECIECGKAFIQNTSLIRHWRYYHTGEKPFDCIDCGKAFSDHIGLNQHRRIHTGEKPYKC 535

  Fly   196 THCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHA-ERSFKCTQCPKTFLQ 259
            ..|.|:|:..|.|..|.|.|...:|::|..|.|:|...:.|.:|...|: |:.|||.:|.|.|.|
Human   536 DVCHKSFRYGSSLTVHQRIHTGEKPYECDVCRKAFSHHASLTQHQRVHSGEKPFKCKECGKAFRQ 600

  Fly   260 NDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVR 324
            |..|..|||:|.||.||:|..|.::|:.:|:|..|...|.|::|.:|..||..|..::....|.:
Human   601 NIHLASHLRIHTGEKPFECAECGKSFSISSQLATHQRIHTGEKPYECKVCSKAFTQKAHLAQHQK 665

  Fly   325 LHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDF----KCRTHLRVHMLDHIGE 385
            .||.|:.|:|.||.|:|.:.:||::||:|||||:|:||..|.|.|    .|..|.|:    |.|:
Human   666 THTGEKPYECKECGKAFSQTTHLIQHQRVHTGEKPYKCMECGKAFGDNSSCTQHQRL----HTGQ 726

  Fly   386 KVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCS 450
            :..:|..|.|.||..|.|:.|.:.|||:..:||..|.|:::...:|.:|.|.|:|:.|::|..|.
Human   727 RPYECIECGKAFKTKSSLICHRRSHTGEKPYECSVCGKAFSHRQSLSVHQRIHSGKKPYECKECR 791

  Fly   451 KLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            |.|.:.....:|.|.||||:.|........:.|.:.|..|.|
Human   792 KTFIQIGHLNQHKRVHTGERSYNYKKSRKVFRQTAHLAHHQR 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	157/410 (38%)
		C2H2 Zn finger	84..104	CDD:275368	9/19 (47%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	9/20 (45%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	10/19 (53%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	7/23 (30%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	3/17 (18%)
ZFP28	NP_065879.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..82
		KRAB	103..163	CDD:214630
		KRAB	232..288	CDD:214630
		COG5048	417..806	CDD:227381	151/392 (39%)
		C2H2 Zn finger	422..442	CDD:275368	9/19 (47%)
		C2H2 Zn finger	450..470	CDD:275368	6/19 (32%)
		C2H2 Zn finger	478..496	CDD:275368	9/17 (53%)
		C2H2 Zn finger	507..527	CDD:275368	6/19 (32%)
		C2H2 Zn finger	535..555	CDD:275368	8/19 (42%)
		C2H2 Zn finger	563..583	CDD:275368	6/19 (32%)
		C2H2 Zn finger	591..611	CDD:275368	10/19 (53%)
		C2H2 Zn finger	619..639	CDD:275368	6/19 (32%)
		C2H2 Zn finger	647..667	CDD:275368	5/19 (26%)
		C2H2 Zn finger	675..695	CDD:275368	9/19 (47%)
		C2H2 Zn finger	703..723	CDD:275368	7/23 (30%)
		C2H2 Zn finger	731..751	CDD:275368	8/19 (42%)
		C2H2 Zn finger	759..779	CDD:275368	6/19 (32%)
		C2H2 Zn finger	787..807	CDD:275368	6/19 (32%)
		C2H2 Zn finger	815..835	CDD:275368	4/19 (21%)