DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF57

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_775751.1	Gene:	ZNF57 / 126295	HGNCID:	13125	Length:	555	Species:	Homo sapiens

Alignment Length:	472	Identity:	166/472 - (35%)
Similarity:	250/472 - (52%)	Gaps:	44/472 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IENFCS------YGKDLEPVKGVPSKLKTCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESH 100
            ::.||:      ||   |.:..:|. |...|...|.::|       ::||:|:..||...:|:.|
Human   105 VDRFCTHNEGNQYG---EAIHQMPD-LTLHKKVSAGEKP-------YECTKCRTVFTHLSSLKRH 158

  Fly   101 LRLHAEERPFECSHCSKSFGRRTHYKR------HLLKH-----EKRPHKCSHCSKTFTQNSSLKQ 154
            ::          |||.:........|:      ||..|     |::|:||..|.:||.....|..
Human   159 VK----------SHCGRKAPPGEECKQACICPSHLHSHGRTDTEEKPYKCQACGQTFQHPRYLSH 213

  Fly   155 HLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEAR 219
            |:..||.|:.:||.||..:|...:....|:|||:::||::|..|.:||...|..|.|:.||...:
Human   214 HVKTHTAEKTYKCEQCRMAFNGFASFTRHVRTHTKDRPYKCQECGRAFIYPSTFQRHMTTHTGEK 278

  Fly   220 PFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSE 283
            |:||.||.|:|......|:|..|| .|:.::|.||.|||..:::|::|:|:|.|:..:||.||.:
Human   279 PYKCQHCGKAFTYPQAFQRHEKTHTGEKPYECKQCGKTFSWSETLRVHMRIHTGDKLYKCEHCGK 343

  Fly   284 TFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLV 348
            .|..:...|.||..|.|::|.:|.||...|...|.:|.|||:||:|:.|||.:|.|:|.......
Human   344 AFTSSRSFQGHLRTHTGEKPYECKQCGKAFTWSSTFREHVRIHTQEQLYKCEQCGKAFTSSRSFR 408

  Fly   349 EHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGK 413
            .|.:.||||:|::|..|.|.|...:..|.|:..|..|::.||.:|.|.|..|.....||:.|||:
Human   409 GHLRTHTGEKPYECKQCGKTFTWSSTFREHVRIHTQEQLHKCEHCGKAFTSSRAFQGHLRMHTGE 473

  Fly   414 NQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCS 478
            ..:||..|.|::|.|||||.|:|.||||.|.||..|...|...:..:.|||.|||:|.::|...|
Human   474 KPYECKQCGKTFTWSSTLHNHVRMHTGEKPHKCKQCGMSFKWHSSFRNHLRMHTGQKSHECQSYS 538

  Fly   479 TRYT-----QKSSLGRH 490
            ..::     .|:|...|
Human   539 KAFSCQVILSKTSESTH 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	153/415 (37%)
		C2H2 Zn finger	84..104	CDD:275368	7/19 (37%)
		C2H2 Zn finger	112..132	CDD:275368	6/25 (24%)
		C2H2 Zn finger	139..159	CDD:275368	6/19 (32%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	9/19 (47%)
		C2H2 Zn finger	334..354	CDD:275368	5/19 (26%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	11/19 (58%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	5/22 (23%)
ZNF57	NP_775751.1	KRAB	4..>44	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	118..134	CDD:275368	5/19 (26%)
		COG5048	138..546	CDD:227381	154/424 (36%)
		C2H2 Zn finger	142..162	CDD:275368	7/29 (24%)
		C2H2 Zn finger	171..190	CDD:275368	4/18 (22%)
		C2H2 Zn finger	198..218	CDD:275368	6/19 (32%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		zf-H2C2_2	267..291	CDD:290200	11/23 (48%)
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		zf-H2C2_2	294..318	CDD:290200	10/23 (43%)
		C2H2 Zn finger	310..330	CDD:275368	9/19 (47%)
		zf-H2C2_2	323..347	CDD:290200	10/23 (43%)
		C2H2 Zn finger	338..358	CDD:275368	7/19 (37%)
		zf-H2C2_2	350..374	CDD:290200	9/23 (39%)
		C2H2 Zn finger	366..386	CDD:275368	9/19 (47%)
		C2H2 Zn finger	394..414	CDD:275368	5/19 (26%)
		zf-H2C2_2	406..430	CDD:290200	9/23 (39%)
		C2H2 Zn finger	422..442	CDD:275368	6/19 (32%)
		C2H2 Zn finger	450..470	CDD:275368	7/19 (37%)
		zf-H2C2_2	466..486	CDD:290200	9/19 (47%)
		C2H2 Zn finger	478..498	CDD:275368	11/19 (58%)
		C2H2 Zn finger	506..526	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910