Protein Alignment CG5245 and ZNF573

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001166161.1
• Gene: ZNF573 / 126231
• HGNCID: 26420
• Length: 665
• Species: Homo sapiens
• Alignment Length: 479
• Identity: 170/479 - (35%)
• Similarity: 249/479 - (51%)
• Gaps: 30/479 - (6%)

  Fly    22 EEELIFISNSDFEELESEIKIENFC---SYGKDLEPVKGVPSKLKTCKSKIAKKRPLRKQTDTFK 83
            |..:|....:.|.:|:.:.:|.::.   :|..|:.         .|....|.|:..|      ::
Human    86 EPWMILREETQFTDLDLQCEIISYIEVPTYETDIS---------STQLQSIYKREKL------YE 135

  Fly    84 CTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHEK-----RPHKCSHCS 143
            |.:|||.|:....|..|.|.|..|||:||..|.|:|  |:.|:  |..|::     :|::|:.|.
Human   136 CKKCQKKFSSGYQLILHHRFHVIERPYECKECGKNF--RSGYQ--LTLHQRFHTGEKPYECTECG 196

  Fly   144 KTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHL 208
            |.|.....|..|...||||:.::|.||..:|...||:..|.|.|:..:|:||..|.:||....||
Human   197 KNFRSGYQLTVHQRFHTGEKTYECRQCGKAFIYASHIVQHERIHTGGKPYECQECGRAFSQGGHL 261

  Fly   209 QEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHA-ERSFKCTQCPKTFLQNDSLQIHLRVHAG 272
            :.|.|.|...:|:||..|.|:|..||.|.:|...|. |:.:.|.:|.|.|.:...|.:|.|||.|
Human   262 RIHQRVHTGEKPYKCKECGKTFSRRSNLVEHGQFHTDEKPYICEKCGKAFRRGHQLTVHQRVHTG 326

  Fly   273 EDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAM-RSLYRVHVRLHTRERQYKCAE 336
            :.|::|..|.:.:...|...||...|.|.:|.:|.:|..||.: |:|.| |..:||.|:.::|.:
Human   327 KKPYECKECGKGYTTASYFLLHQRIHKGGKPYECKECKKTFTLYRNLTR-HQNIHTGEKLFECKQ 390

  Fly   337 CSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSS 401
            |.|::...|.|.:||:.||||:|::|..|.|.|....:|:.|...|.|.|..:|..|.|.|.|..
Human   391 CGKTYTTGSKLFQHQKTHTGEKPYECKECGKAFSLYGYLKQHQKIHTGMKHFECKECKKTFTLYR 455

  Fly   402 QLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTH 466
            .|..|...||||..|||..|.|:|:|.|.|..|.:|||||.|:||..|.|.|:......:|.:.|
Human   456 NLTRHQNIHTGKKLFECQECGKAYSTGSNLIQHRKTHTGEKPYKCKECGKTFSLHGYLNQHQKIH 520

  Fly   467 TGEKPYKCSHCSTRYTQKSSLGRH 490
            ||.|||:|..|...:|...:|..|
Human   521 TGMKPYECKVCRKTFTFYRNLTLH 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	156/410 (38%)
		C2H2 Zn finger	84..104	CDD:275368	8/19 (42%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	6/19 (32%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	8/20 (40%)
		C2H2 Zn finger	334..354	CDD:275368	7/19 (37%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	5/19 (26%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
ZNF573	NP_001166161.1	KRAB	28..89	CDD:214630	1/2 (50%)
		C2H2 Zn finger	136..156	CDD:275368	8/19 (42%)
		COG5048	160..521	CDD:227381	138/365 (38%)
		C2H2 Zn finger	164..184	CDD:275368	8/23 (35%)
		C2H2 Zn finger	192..212	CDD:275368	6/19 (32%)
		C2H2 Zn finger	220..240	CDD:275368	8/19 (42%)
		C2H2 Zn finger	248..268	CDD:275368	8/19 (42%)
		C2H2 Zn finger	276..292	CDD:275368	7/15 (47%)
		C2H2 Zn finger	304..324	CDD:275368	7/19 (37%)
		C2H2 Zn finger	332..352	CDD:275368	5/19 (26%)
		C2H2 Zn finger	360..380	CDD:275368	8/20 (40%)
		C2H2 Zn finger	388..408	CDD:275368	7/19 (37%)
		C2H2 Zn finger	416..436	CDD:275368	6/19 (32%)
		COG5048	442..>664	CDD:227381	44/103 (43%)
		C2H2 Zn finger	444..464	CDD:275368	7/19 (37%)
		C2H2 Zn finger	472..492	CDD:275368	8/19 (42%)
		C2H2 Zn finger	500..520	CDD:275368	5/19 (26%)
		C2H2 Zn finger	528..548	CDD:275368	5/17 (29%)
		C2H2 Zn finger	556..576	CDD:275368
		C2H2 Zn finger	584..604	CDD:275368
		C2H2 Zn finger	612..632	CDD:275368
		C2H2 Zn finger	640..660	CDD:275368