DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF813

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001004301.2	Gene:	ZNF813 / 126017	HGNCID:	33257	Length:	617	Species:	Homo sapiens

Alignment Length:	503	Identity:	177/503 - (35%)
Similarity:	266/503 - (52%)	Gaps:	36/503 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DLANVDQRPVKDEPPQEDTFEEELIFISNSDFEELESEIKIENFCSYGKDLEPVKGVPSKLK-TC 65
            |..:...:|:||:  ...:|...|     .:....:::.||.|  ...|.:.....:.:..: :|
Human   127 DQRHAGNKPIKDQ--LGSSFHSHL-----PELHMFQTQGKIGN--QVEKSINDASSISTSQRISC 182

  Fly    66 KSK----------------IAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSH 114
            :.|                :.:|:.:..:..:|:|.:..|.|.....|..|..:|..|:.::|..
Human   183 RPKTHISNNYGNNFRNSSLLTQKQEVHMREKSFQCNESGKAFNYSSLLRKHQIIHLGEKQYKCDV 247

  Fly   115 CSKSFGRRTHYKRHLLKHEK-----RPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSF 174
            |.|.|.|    ||:|:.|.:     :|::|:.|.|||:|..||..|...||||:|:||.:|..:|
Human   248 CGKVFNR----KRNLVCHRRCHTGEKPYRCNECGKTFSQTYSLTCHRRLHTGEKPYKCEECDKAF 308

  Fly   175 ARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKH 239
            :.||:|:.|.|.|:.|:|::|..|.|.|...|.|..|.|.|...:||||:.|.|:|..:|.|..|
Human   309 SFKSNLKRHRRIHAGEKPYKCNECGKTFSQTSSLTCHRRLHTGEKPFKCNECGKTFSRKSSLTCH 373

  Fly   240 LLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEP 303
            ...| .|:.:||.:|.|||.|..:|:.|.|:|.||.|:||..|.:.|.:.:.|..|...|:|::|
Human   374 HRLHTGEKPYKCNECGKTFSQELTLKCHRRLHTGEKPYKCNECGKVFNKKANLARHHRLHSGEKP 438

  Fly   304 LKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKD 368
            .||::|..||:..|...:|..:|..|::|||.||.|:|.:.|.||.|..:||||:|:||..|.|.
Human   439 YKCTECVKTFSRNSALVIHKAIHIGEKRYKCNECGKTFSRISALVIHTAIHTGEKPYKCNECGKG 503

  Fly   369 FKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHM 433
            |..:|||..|...|.|||..||:.|.|.|...:.|..|.:.|||...::|..|.|.:...:.|..
Human   504 FNRKTHLACHHRLHTGEKPYKCNECGKVFNRKTHLAHHHRLHTGDKPYKCNECGKVFNQKAHLAR 568

  Fly   434 HLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRY 481
            |.|.||||.|:||:.|.|:|.:.|....|.|.||||||||.:.|...:
Human   569 HHRLHTGEKPYKCNECGKVFNQKANLARHHRLHTGEKPYKFNECGKAF 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	163/409 (40%)
		C2H2 Zn finger	84..104	CDD:275368	5/19 (26%)
		C2H2 Zn finger	112..132	CDD:275368	8/19 (42%)
		C2H2 Zn finger	139..159	CDD:275368	9/19 (47%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	8/19 (42%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	1/8 (13%)
ZNF813	NP_001004301.2	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	191..602	CDD:227381	156/414 (38%)
		C2H2 Zn finger	217..237	CDD:275368	5/19 (26%)
		zf-H2C2_2	230..254	CDD:290200	8/23 (35%)
		C2H2 Zn finger	245..265	CDD:275368	9/23 (39%)
		zf-H2C2_2	257..282	CDD:290200	8/24 (33%)
		C2H2 Zn finger	273..293	CDD:275368	9/19 (47%)
		zf-H2C2_2	285..309	CDD:290200	11/23 (48%)
		C2H2 Zn finger	301..321	CDD:275368	8/19 (42%)
		zf-H2C2_2	313..338	CDD:290200	10/24 (42%)
		C2H2 Zn finger	329..349	CDD:275368	8/19 (42%)
		zf-H2C2_2	341..366	CDD:290200	11/24 (46%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		zf-H2C2_2	369..394	CDD:290200	10/24 (42%)
		C2H2 Zn finger	385..405	CDD:275368	9/19 (47%)
		zf-H2C2_2	398..421	CDD:290200	10/22 (45%)
		C2H2 Zn finger	413..433	CDD:275368	5/19 (26%)
		C2H2 Zn finger	441..461	CDD:275368	6/19 (32%)
		C2H2 Zn finger	469..489	CDD:275368	9/19 (47%)
		C2H2 Zn finger	497..517	CDD:275368	8/19 (42%)
		zf-H2C2_2	509..534	CDD:290200	12/24 (50%)
		C2H2 Zn finger	525..545	CDD:275368	6/19 (32%)
		C2H2 Zn finger	553..573	CDD:275368	6/19 (32%)
		zf-H2C2_2	565..590	CDD:290200	13/24 (54%)
		C2H2 Zn finger	581..601	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900