Protein Alignment CG5245 and ZNF543

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_998763.2
• Gene: ZNF543 / 125919
• HGNCID: 25281
• Length: 600
• Species: Homo sapiens
• Alignment Length: 506
• Identity: 173/506 - (34%)
• Similarity: 249/506 - (49%)
• Gaps: 71/506 - (14%)

  Fly     9 RPVKDEP-------PQEDTFEEELI--FISNSDF----------EELESEIKIENFCSYGKDLEP 54
            :|...||       |:|...:|:|.  ...||..          |..|..:||......||.||.
Human    85 KPKTTEPTFSHLALPEEVLLQEQLTQGASKNSQLGQSKDQDGPSEMQEVHLKIGIGPQRGKLLEK 149

  Fly    55 VK----GVPSKLKTCKSKIAKKRP-------------------LRKQTDTFKCTQCQKTFTRKEN 96
            :.    |:.|....| :||.:|:.                   :|::.:::||.:|.|.|.:...
Human   150 MSSERDGLGSDDGVC-TKITQKQVSTEGDLYECDSHGPVTDALIREEKNSYKCEECGKVFKKNAL 213

  Fly    97 LESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHEKRPHKCSHCSKTFTQNSSLKQHLHEHTG 161
            |..|.|:|.:.:|:||:.|.|:|.:.||                           |.|||..|||
Human   214 LVQHERIHTQVKPYECTECGKTFSKSTH---------------------------LLQHLIIHTG 251

  Fly   162 ERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHC 226
            |:|:||.:|..:|.|:|||..|.|.||.|:|::|:.|.|||.:.|....|.|:|...:||.|..|
Human   252 EKPYKCMECGKAFNRRSHLTRHQRIHSGEKPYKCSECGKAFTHRSTFVLHHRSHTGEKPFVCKEC 316

  Fly   227 SKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSR 290
            .|:|:.|....:|.:.| .|:.::|.:|.|.|.:...|..|.::|.|..||:|..|.:.|..::.
Human   317 GKAFRDRPGFIRHYIIHTGEKPYECIECGKAFNRRSYLTWHQQIHTGVKPFECNECGKAFCESAD 381

  Fly   291 LQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHT 355
            |..|.:.|.|::|.||.:|...|..||..:.|.|:||.|:.|:|:||.|:|...|..|.|::.||
Human   382 LIQHYIIHTGEKPYKCMECGKAFNRRSHLKQHQRIHTGEKPYECSECGKAFTHCSTFVLHKRTHT 446

  Fly   356 GERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPH 420
            ||:|::|..|.|.|..|..|..|...|.|||..:|..|.|.|..||.|..|.|.|||:..:||..
Human   447 GEKPYECKECGKAFSDRADLIRHFSIHTGEKPYECVECGKAFNRSSHLTRHQQIHTGEKPYECIQ 511

  Fly   421 CSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKP 471
            |.|::..|:.|..|...||||.|::||.|.|.|.|.:....|.|.|||..|
Human   512 CGKAFCRSANLIRHSIIHTGEKPYECSECGKAFNRGSSLTHHQRIHTGRNP 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	150/418 (36%)
		C2H2 Zn finger	84..104	CDD:275368	7/19 (37%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	4/19 (21%)
		C2H2 Zn finger	167..187	CDD:275368	9/19 (47%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..492	CDD:275368
ZNF543	NP_998763.2	KRAB	9..69	CDD:214630
		COG5048	<75..329	CDD:227381	80/271 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	110..131		3/20 (15%)
		C2H2 Zn finger	201..221	CDD:275368	7/19 (37%)
		COG5048	223..562	CDD:227381	139/365 (38%)
		C2H2 Zn finger	229..249	CDD:275368	10/46 (22%)
		C2H2 Zn finger	257..277	CDD:275368	9/19 (47%)
		C2H2 Zn finger	285..305	CDD:275368	8/19 (42%)
		C2H2 Zn finger	313..333	CDD:275368	6/19 (32%)
		C2H2 Zn finger	341..361	CDD:275368	6/19 (32%)
		C2H2 Zn finger	369..389	CDD:275368	5/19 (26%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		C2H2 Zn finger	425..445	CDD:275368	8/19 (42%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		C2H2 Zn finger	481..501	CDD:275368	9/19 (47%)
		C2H2 Zn finger	509..529	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)