Protein Alignment CG5245 and ZNF816

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001026835.1
• Gene: ZNF816 / 125893
• HGNCID: 26995
• Length: 651
• Species: Homo sapiens
• Alignment Length: 524
• Identity: 178/524 - (33%)
• Similarity: 268/524 - (51%)
• Gaps: 47/524 - (8%)

  Fly     2 DLANVDQRPVKDE--------PPQEDTF----------EEELIFISNSDFEELESEIKIENFCSY 48
            |..:...:|:||:        .|:...|          ::.:...|.|:.:.:...:|......|
Human   143 DHRHAGNKPIKDQLGLSFHSHLPELHMFQTKGKISNQLDKSIGASSASESQRISCRLKTHISNKY 207

  Fly    49 GKD-----LEPVKGVPSKLKTCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEER 108
            ||:     ...::.:..:.|.|:|                 .:|.|.|.....|..|...|:.||
Human   208 GKNFLHSSFTQIQEICMREKPCQS-----------------NECGKAFNYSSLLRRHHITHSRER 255

  Fly   109 PFECSHCSKSFGRRTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCST 172
            .::|..|.|.|.::.:...|...|. ::.:||:.|.|||||.|||..|...||||:|:||.:|..
Human   256 EYKCDVCGKIFNQKQYIVYHHRCHTGEKTYKCNECGKTFTQMSSLVCHRRLHTGEKPYKCNECGK 320

  Fly   173 SFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQ 237
            :|:.||.|:.|.|.|:.|:|::|..|.|.|..||.|..|...|...:|:||:.|.|:|..:|.||
Human   321 TFSEKSSLRCHRRLHTGEKPYKCNECGKTFGRNSALVIHKAIHTGEKPYKCNECGKTFSQKSSLQ 385

  Fly   238 KHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGK 301
            .|.:.| .|:.:||.:|...:::...|:.|.::|.||..:||..|.:.|..:|.|..|...|.|:
Human   386 CHHILHTGEKPYKCEECDNVYIRRSHLERHRKIHTGEGSYKCKVCDKVFRSDSYLAEHQRVHTGE 450

  Fly   302 EPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCF 366
            :|.||::|..:|:.:|..:.|..|||.|:.|.|.||.|.|.::.:|..|.::|.||:|:||..|.
Human   451 KPYKCNKCGRSFSRKSSLQYHHTLHTGEKPYTCNECGKVFSRRENLARHHRLHAGEKPYKCEECD 515

  Fly   367 KDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTL 431
            |.|..|:||..|...|.|||..||..|.|.|:..|.|..|.:.|||:..::|..|:|.:.....|
Human   516 KVFSRRSHLERHRRIHTGEKPYKCKVCDKAFRSDSCLANHTRVHTGEKPYKCNKCAKVFNQKGIL 580

  Fly   432 HMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRH-----L 491
            ..|.|.||||.|:||:.|.|:|.:.|...:|.|.||.||||||:.|...:|.:|:|..|     .
Human   581 AQHQRVHTGEKPYKCNECGKVFNQKASLAKHQRVHTAEKPYKCNECGKAFTGQSTLIHHQAIHGC 645

  Fly   492 RRTL 495
            |.||
Human   646 RETL 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	155/405 (38%)
		C2H2 Zn finger	84..104	CDD:275368	5/19 (26%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	11/19 (58%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	4/19 (21%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	7/19 (37%)
		C2H2 Zn finger	362..382	CDD:275368	8/19 (42%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	6/22 (27%)
ZNF816	NP_001026835.1	KRAB	24..64	CDD:460171
		C2H2 Zn finger	232..251	CDD:275368	5/18 (28%)
		C2H2 Zn finger	259..279	CDD:275368	5/19 (26%)
		COG5048	283..650	CDD:227381	149/367 (41%)
		C2H2 Zn finger	287..307	CDD:275368	11/19 (58%)
		C2H2 Zn finger	315..335	CDD:275368	8/19 (42%)
		C2H2 Zn finger	343..363	CDD:275368	8/19 (42%)
		C2H2 Zn finger	371..391	CDD:275368	8/19 (42%)
		C2H2 Zn finger	399..419	CDD:275368	4/19 (21%)
		C2H2 Zn finger	427..447	CDD:275368	6/19 (32%)
		C2H2 Zn finger	455..475	CDD:275368	5/19 (26%)
		C2H2 Zn finger	483..503	CDD:275368	7/19 (37%)
		C2H2 Zn finger	511..531	CDD:275368	8/19 (42%)
		C2H2 Zn finger	539..559	CDD:275368	7/19 (37%)
		C2H2 Zn finger	567..587	CDD:275368	6/19 (32%)
		C2H2 Zn finger	595..615	CDD:275368	7/19 (37%)
		C2H2 Zn finger	623..643	CDD:275368	6/19 (32%)