DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZFP3

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_694563.1	Gene:	ZFP3 / 124961	HGNCID:	12861	Length:	502	Species:	Homo sapiens

Alignment Length:	452	Identity:	165/452 - (36%)
Similarity:	244/452 - (53%)	Gaps:	29/452 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VKDEPPQEDTFEEELIFISNSDFEELESE-IKIENFCSYGKDL-----EPVKGVPS--------- 60
            ::...|||..|...|:....|...|.:.| .:.|..||...:|     :..:||.:
Human    59 IEQMSPQERDFPSGLMIFKKSPSSEKDRENNESERGCSPSPNLVTHQGDTTEGVSAFATSGQNFL 123

  Fly    61 ----KLKTCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGR 121
                ..||.:|.:.:|        ...|.:|.|.|.:..:|..|:|:|:.|:||||..|.|:||.
Human   124 EILESNKTQRSSVGEK--------PHTCKECGKAFNQNSHLIQHMRVHSGEKPFECKECGKTFGT 180

  Fly   122 RTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLR 185
            .:..:|||..|. ::|..|:.|.|.|.|:|.|..|...||||||:||.:|..:|::.|.|.:|.|
Human   181 NSSLRRHLRIHAGEKPFACNECGKAFIQSSHLIHHHRIHTGERPYKCEECGKAFSQNSALILHQR 245

  Fly   186 THSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFK 249
            .|:.|:|:||..|.|.|:.:|.|.:|.|.|.|.|..:|:.|.|:||..|.|.:|...| .|:.:.
Human   246 IHTGEKPYECNECGKTFRVSSQLIQHQRIHTEERYHECNECGKAFKHSSGLIRHQKIHTGEKPYL 310

  Fly   250 CTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFA 314
            |.:|.|.|.|:..|..|.|:|.|:.|::|..|.:||.:||.:..|:..|.|::|..|.:|...|.
Human   311 CNECGKGFGQSSELIRHQRIHTGDKPYECNECGKTFGQNSEIIRHIRIHTGEKPYVCKECGKAFR 375

  Fly   315 MRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHM 379
            ..|....|.|:||.|:.|:|.||.|:|.:.|||:.||::||||:|.:|..|.:.|...:.|.:|.
Human   376 GNSELLRHERIHTGEKPYECFECGKAFRRTSHLIVHQRIHTGEKPHQCNECARTFWDNSELLLHQ 440

  Fly   380 LDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGE 441
            ..|||||..:||.|.|.|...|||::|.:.|||:..:||..|.|:::.||.|..|...|..|
Human   441 KIHIGEKPYECSECEKTFSQHSQLIIHQRIHTGEKPYECQECQKTFSRSSHLLRHQSVHCME 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	147/370 (40%)
		C2H2 Zn finger	84..104	CDD:275368	7/19 (37%)
		C2H2 Zn finger	112..132	CDD:275368	8/19 (42%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	11/24 (46%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	5/19 (26%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368
		C2H2 Zn finger	474..492	CDD:275368
ZFP3	NP_694563.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..103		12/43 (28%)
		COG5048	139..495	CDD:227381	145/363 (40%)
		C2H2 Zn finger	143..163	CDD:275368	7/19 (37%)
		C2H2 Zn finger	171..191	CDD:275368	8/19 (42%)
		C2H2 Zn finger	199..219	CDD:275368	8/19 (42%)
		C2H2 Zn finger	227..247	CDD:275368	7/19 (37%)
		C2H2 Zn finger	255..275	CDD:275368	8/19 (42%)
		C2H2 Zn finger	283..303	CDD:275368	8/19 (42%)
		C2H2 Zn finger	311..331	CDD:275368	8/19 (42%)
		C2H2 Zn finger	339..359	CDD:275368	7/19 (37%)
		C2H2 Zn finger	367..387	CDD:275368	6/19 (32%)
		C2H2 Zn finger	395..415	CDD:275368	10/19 (53%)
		C2H2 Zn finger	423..443	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	9/19 (47%)
		C2H2 Zn finger	479..499	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000