Protein Alignment CG5245 and ZIM3

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_443114.1
• Gene: ZIM3 / 114026
• HGNCID: 16366
• Length: 472
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 146/532 - (27%)
• Similarity: 241/532 - (45%)
• Gaps: 130/532 - (24%)

  Fly    20 TFEEELIFISNSDFEELESE-------IKIENFCS-----YGKDLEP------------------ 54
            |||:..:..:..:::.|..|       :.:||:.:     .|:..:|
Human     9 TFEDVTVNFTQGEWQRLNPEQRNLYRDVMLENYSNLVSVGQGETTKPDVILRLEQGKEPWLEEEE 73

  Fly    55 ------------VKGVPSKLKTCKSKIAKKRP-LRKQT-DTFKCTQCQKTFTRK---------EN 96
                        :.|...|.|..|..:|::.| :.|:| .|.|..:|..  ::|         .:
Human    74 VLGSGRAEKNGDIGGQIWKPKDVKESLAREVPSINKETLTTQKGVECDG--SKKILPLGIDDVSS 136

  Fly    97 LESHLRLHAEE----RPFECSHCSKSFGRRTHYKRHLLKHEKRPHKCSHCSKTFTQNSSLKQHLH 157
            |:.:::.::.:    |....::.||..|::.              ||:.|.|.|:..|.|:.||.
Human   137 LQHYVQNNSHDDNGYRKLVGNNPSKFVGQQL--------------KCNACRKLFSSKSRLQSHLR 187

  Fly   158 EHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFK 222
            .|..::||:|..|..:|..|..|..|.:||:||||::|.:|..|:|..|:|.:|.:.|.:.:|::
Human   188 RHACQKPFECHSCGRAFGEKWKLDKHQKTHAEERPYKCENCGNAYKQKSNLFQHQKMHTKEKPYQ 252

  Fly   223 CSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFA 286
            |..|.|:|..:|....|...| |::|::|.:|.|:|.||.:|..|.:||.|:.||:|..|.:.|.
Human   253 CKTCGKAFSWKSSCINHEKIHNAKKSYQCNECEKSFRQNSTLIQHKKVHTGQKPFQCTDCGKAFI 317

  Fly   287 RNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQ 351
            ..|.|..|...|.|::|.|||.|...|:.:|....|.::||.:|.|:|..|..:|.:|.:|::|:
Human   318 YKSDLVKHQRIHTGEKPYKCSICEKAFSQKSNVIDHEKIHTGKRAYECDLCGNTFIQKKNLIQHK 382

  Fly   352 QVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQF 416
            ::||||:|                                                        :
Human   383 KIHTGEKP--------------------------------------------------------Y 391

  Fly   417 ECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRY 481
            ||..|.|::...|.||.|.:||:||..::||.|.|.|.|......|.:||||:|||.||.|...:
Human   392 ECNRCGKAFFQKSNLHSHQKTHSGERTYRCSECGKTFIRKLNLSLHKKTHTGQKPYGCSECGKAF 456

  Fly   482 TQKSSLGRHLRR 493
            ..:|.|.||.:|
Human   457 ADRSYLVRHQKR 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	126/419 (30%)
		C2H2 Zn finger	84..104	CDD:275368	3/28 (11%)
		C2H2 Zn finger	112..132	CDD:275368	3/19 (16%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	6/19 (32%)
		C2H2 Zn finger	362..382	CDD:275368	0/19 (0%)
		C2H2 Zn finger	390..410	CDD:275368	0/19 (0%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	7/17 (41%)
ZIM3	NP_443114.1	KRAB	8..68	CDD:214630	9/58 (16%)
		COG5048	<157..348	CDD:227381	72/204 (35%)
		C2H2 Zn finger	169..189	CDD:275368	8/19 (42%)
		C2H2 Zn finger	197..217	CDD:275368	6/19 (32%)
		C2H2 Zn finger	225..245	CDD:275368	7/19 (37%)
		zf-H2C2_2	237..261	CDD:463886	7/23 (30%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		C2H2 Zn finger	281..301	CDD:275368	8/19 (42%)
		COG5048	<304..465	CDD:227381	64/216 (30%)
		C2H2 Zn finger	309..329	CDD:275368	6/19 (32%)
		C2H2 Zn finger	337..357	CDD:275368	6/19 (32%)
		C2H2 Zn finger	393..413	CDD:275368	7/19 (37%)
		C2H2 Zn finger	421..441	CDD:275368	7/19 (37%)
		C2H2 Zn finger	449..470	CDD:275368	8/20 (40%)