DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF660-ZNF197

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001338661.1	Gene:	ZNF660-ZNF197 / 110354863	-ID:	-	Length:	1029	Species:	Homo sapiens

Alignment Length:	537	Identity:	183/537 - (34%)
Similarity:	275/537 - (51%)	Gaps:	78/537 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PQEDTFEEELIFISNSDFEELESEIKIENFCSYGKDLEPVKGVPSKLKTCKSKIAKKRPLRKQTD 80
            ||...||||      .:::.|.|:        :|.:.:.......|:..|:....|:.|..||..
Human   292 PQVLDFEEE------CEWQVLASQ--------WGNETDERADTVKKVSLCERDKKKRTPPEKQGQ 342

  Fly    81 T--------------------------FKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSF 119
            .                          :||..|.|.|.:..:|.:|.|:|..|:|.:|..|.|.|
Human   343 KWKELGDSLTFGSAISESLIGTEGKKFYKCDMCCKHFNKISHLINHRRIHTGEKPHKCKECGKGF 407

  Fly   120 GRRTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVH 183
            .:|:....||..|. ::|:||:.|.|.|:|::.|..|...||||:|:||.:|...|.|.|.|.:|
Human   408 IQRSSLLMHLRNHSGEKPYKCNECGKAFSQSAYLLNHQRIHTGEKPYKCKECGKGFYRHSGLIIH 472

  Fly   184 LRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH----- 243
            ||.||.|||::|..|.|.|..|::|.:|.|.|:...|:||:.|.|:|    ||:|.|:.|
Human   473 LRRHSGERPYKCNECGKVFSQNAYLIDHQRLHKGEEPYKCNKCQKAF----ILKKSLILHQRIHS 533

  Fly   244 AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQ 308
            .|:.:||.:|.|||.|...|..|.|:|:.|:|:||..|.:.|.|:..|.||...|..|:...|.:
Human   534 GEKPYKCDECGKTFAQTTYLIDHQRLHSAENPYKCKECGKVFIRSKSLLLHQRVHTEKKTFGCKK 598

  Fly   309 CSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRT 373
            |...|:.:|.:..|.|:|:||:.|||.||.|:|.:.::|.:||::|.||:|::|..|.|.|..:.
Human   599 CGKIFSSKSNFIDHKRMHSREKPYKCTECGKAFTQSAYLFDHQRLHNGEKPYECNECGKVFILKK 663

  Fly   374 HLRVH------------------------MLD----HIGEKVPKCSYCSKEFKLSSQLLVHLQEH 410
            .|.:|                        ::|    |.|||..:|..|.|.|.:|...:||.:.|
Human   664 SLILHQRFHTGENLYECKDCGKVFGSNRNLIDHERLHNGEKPYECRECGKTFIMSKSFMVHQKLH 728

  Fly   411 TGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCS 475
            |.:..::|..|.|:::.:|:|.:|.|.||||.||:||.|.:.|:.:....||.|.|:|||||:|.
Human   729 TQEKAYKCEDCGKAFSYNSSLLVHRRIHTGEKPFECSECGRAFSSNRNLIEHKRIHSGEKPYECD 793

  Fly   476 HCSTRYTQKSSLGRHLR 492
            .|...:..|.||..|.|
Human   794 ECGKCFILKKSLIGHQR 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	165/463 (36%)
		C2H2 Zn finger	84..104	CDD:275368	7/19 (37%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	9/19 (47%)
		zf-H2C2_2	179..204	CDD:290200	13/24 (54%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	7/47 (15%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
ZNF660-ZNF197	NP_001338661.1	SCAN	38..150	CDD:128708
		KRAB	216..256	CDD:307490
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..290
		C2H2 Zn finger	372..392	CDD:275368	7/19 (37%)
		zf-H2C2_2	384..409	CDD:316026	10/24 (42%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		COG5048	424..853	CDD:227381	149/391 (38%)
		C2H2 Zn finger	428..448	CDD:275368	7/19 (37%)
		C2H2 Zn finger	456..476	CDD:275368	9/19 (47%)
		C2H2 Zn finger	484..504	CDD:275368	8/19 (42%)
		C2H2 Zn finger	512..532	CDD:275368	9/23 (39%)
		C2H2 Zn finger	540..560	CDD:275368	9/19 (47%)
		C2H2 Zn finger	568..588	CDD:275368	7/19 (37%)
		C2H2 Zn finger	596..616	CDD:275368	6/19 (32%)
		C2H2 Zn finger	624..644	CDD:275368	8/19 (42%)
		C2H2 Zn finger	652..672	CDD:275368	6/19 (32%)
		C2H2 Zn finger	680..700	CDD:275368	1/19 (5%)
		C2H2 Zn finger	708..728	CDD:275368	7/19 (37%)
		C2H2 Zn finger	736..756	CDD:275368	7/19 (37%)
		COG5048	760..>1026	CDD:227381	22/51 (43%)
		C2H2 Zn finger	764..784	CDD:275368	7/19 (37%)
		C2H2 Zn finger	792..812	CDD:275368	7/19 (37%)
		C2H2 Zn finger	820..840	CDD:275368
		C2H2 Zn finger	848..868	CDD:275368
		C2H2 Zn finger	876..896	CDD:275368
		C2H2 Zn finger	904..924	CDD:275368
		C2H2 Zn finger	932..952	CDD:275368
		C2H2 Zn finger	960..980	CDD:275368
		C2H2 Zn finger	988..1008	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900