DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and Mzf1

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_006539528.1	Gene:	Mzf1 / 109889	MGIID:	107457	Length:	814	Species:	Mus musculus

Alignment Length:	376	Identity:	149/376 - (39%)
Similarity:	200/376 - (53%)	Gaps:	18/376 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 RPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCE 199
            |..:|..|.|.|:|.|:|.:|...|||||||.|.:|..||:|.|||..|..||:|||||.|..|.
Mouse   434 RGGRCDVCGKVFSQRSNLLRHQKIHTGERPFVCGECGRSFSRSSHLLRHQLTHTEERPFVCRDCG 498

  Fly   200 KAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHAE------------------R 246
            :.|..::.|:||.|.|...:||:|:.|.:||:.||.|.:|...|.:                  .
Mouse   499 QGFVRSARLEEHRRVHTGEQPFRCTECGQSFRQRSNLLQHQRIHGDPPGPAPSILPLAGVPEPPG 563

  Fly   247 SFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSA 311
            .|.|::|.::|.:...|..|..||.|:..|.|..|.|.|.|.|.|..|...|:|:.|..|::|..
Mouse   564 PFPCSECCESFPRRAVLLEHQAVHTGDKSFGCVECGERFGRRSVLLQHRRVHSGERPFACAECGQ 628

  Fly   312 TFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLR 376
            :|..||....|.|:||.||.:.||||.|:|.::..|.:|.:|||||:||.|..|.:.|..|..|.
Mouse   629 SFRQRSNLTQHQRIHTGERPFACAECGKTFRQRPTLTQHLRVHTGEKPFACPECGQRFSQRLKLT 693

  Fly   377 VHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGE 441
            .|...|.|||...|..|...|...|:|..|.:.|||:..|.||.|.:|:...:.|..|.|.||||
Mouse   694 RHQRTHTGEKPYCCGECGLGFTQVSRLTEHQRIHTGERPFACPECGQSFRQHANLTQHRRIHTGE 758

  Fly   442 LPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            .|:.|..|.|.|.:.....:|||||..|||:.|..|..|:.|.:.|.:|.|
Mouse   759 RPYACPECGKAFRQRPTLTQHLRTHRHEKPFACQDCGRRFNQSTKLIQHQR 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	143/360 (40%)
		C2H2 Zn finger	84..104	CDD:275368
		C2H2 Zn finger	112..132	CDD:275368
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	9/19 (47%)
		zf-H2C2_2	179..204	CDD:290200	13/24 (54%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	5/19 (26%)
		C2H2 Zn finger	278..298	CDD:275368	8/19 (42%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
Mzf1	XP_006539528.1	SCAN	121..232	CDD:128708
		COG5048	416..807	CDD:227381	147/372 (40%)
		C2H2 Zn finger	438..458	CDD:275368	8/19 (42%)
		C2H2 Zn finger	466..486	CDD:275368	9/19 (47%)
		C2H2 Zn finger	494..514	CDD:275368	7/19 (37%)
		C2H2 Zn finger	522..542	CDD:275370	8/19 (42%)
		C2H2 Zn finger	567..587	CDD:275368	5/19 (26%)
		C2H2 Zn finger	595..615	CDD:275368	8/19 (42%)
		C2H2 Zn finger	623..643	CDD:275368	7/19 (37%)
		C2H2 Zn finger	651..671	CDD:275368	8/19 (42%)
		C2H2 Zn finger	679..699	CDD:275368	6/19 (32%)
		C2H2 Zn finger	707..727	CDD:275368	6/19 (32%)
		C2H2 Zn finger	735..755	CDD:275368	7/19 (37%)
		C2H2 Zn finger	763..783	CDD:275368	7/19 (37%)
		C2H2 Zn finger	791..811	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910