DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF267

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_003405.4	Gene:	ZNF267 / 10308	HGNCID:	13060	Length:	743	Species:	Homo sapiens

Alignment Length:	455	Identity:	176/455 - (38%)
Similarity:	247/455 - (54%)	Gaps:	34/455 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 KQTDTFKCTQCQKTFTR------------KEN------------LESHLR---LHAEERPFECSH 114
            ||..::||.:|.:..|:            :||            ..|:||   :|.||:|::|..
Human   262 KQEQSYKCNKCVEVCTQSLKHIQHQTIHIRENSYSYNKYDKDLSQSSNLRKQIIHNEEKPYKCEK 326

  Fly   115 CSKSFGRRTHYKRH-LLKHEKRPHKCSHCSKTFTQNSSL---KQHLHEHTGERPFKCTQCSTSFA 175
            |..|.....|..:| ::..|::|.|...|.|.|..|.||   ||...: |||..:||..||.||.
Human   327 CGDSLNHSLHLTQHQIIPTEEKPCKWKECGKVFNLNCSLYLTKQQQID-TGENLYKCKACSKSFT 390

  Fly   176 RKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHL 240
            |.|:|.||.|.|:.|:|::|..|.|||:.:|:|.:|.|.|...:|:||..|.|:|...|.|.:|.
Human   391 RSSNLIVHQRIHTGEKPYKCKECGKAFRCSSYLTKHKRIHTGEKPYKCKECGKAFNRSSCLTQHQ 455

  Fly   241 LTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPL 304
            .|| .|:.:||..|.|::.::.:|.:|.|||.||.|:||..|.:.|:|:|.|..|...|.|:...
Human   456 TTHTGEKLYKCKVCSKSYARSSNLIMHQRVHTGEKPYKCKECGKVFSRSSCLTQHRKIHTGENLY 520

  Fly   305 KCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDF 369
            ||..|:..|...|...||.|:||.|:.|||.||.|:|...|||:.|.::||||:|:||..|.|.|
Human   521 KCKVCAKPFTCFSNLIVHERIHTGEKPYKCKECGKAFPYSSHLIRHHRIHTGEKPYKCKACSKSF 585

  Fly   370 KCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMH 434
            ...:.|.||...|.|||...|..|.|.|..||.::.|.:.|||:..::|..|.|::...|.|..|
Human   586 SDSSGLTVHRRTHTGEKPYTCKECGKAFSYSSDVIQHRRIHTGQRPYKCEECGKAFNYRSYLTTH 650

  Fly   435 LRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLRRTLCGTK 499
            .|:||||.|:||..|.|.|...:....|.|.||||:||||..|...::.:|.|..| ||:..|.:
Human   651 QRSHTGERPYKCEECGKAFNSRSYLTTHRRRHTGERPYKCDECGKAFSYRSYLTTH-RRSHSGER 714

Fly 500 499
Human 715 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	169/432 (39%)
		C2H2 Zn finger	84..104	CDD:275368	8/46 (17%)
		C2H2 Zn finger	112..132	CDD:275368	5/20 (25%)
		C2H2 Zn finger	139..159	CDD:275368	8/22 (36%)
		C2H2 Zn finger	167..187	CDD:275368	11/19 (58%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
ZNF267	NP_003405.4	KRAB	4..64	CDD:214630
		C2H2 Zn finger	269..289	CDD:275368	3/19 (16%)
		C2H2 Zn finger	297..316	CDD:275368	3/18 (17%)
		C2H2 Zn finger	324..341	CDD:275368	4/16 (25%)
		C2H2 Zn finger	353..374	CDD:275368	8/20 (40%)
		COG5048	364..730	CDD:227381	149/353 (42%)
		C2H2 Zn finger	382..402	CDD:275368	11/19 (58%)
		C2H2 Zn finger	410..430	CDD:275368	9/19 (47%)
		C2H2 Zn finger	438..458	CDD:275368	7/19 (37%)
		C2H2 Zn finger	466..486	CDD:275368	6/19 (32%)
		C2H2 Zn finger	494..514	CDD:275368	7/19 (37%)
		C2H2 Zn finger	522..542	CDD:275368	7/19 (37%)
		C2H2 Zn finger	550..570	CDD:275368	9/19 (47%)
		C2H2 Zn finger	578..598	CDD:275368	7/19 (37%)
		C2H2 Zn finger	606..626	CDD:275368	7/19 (37%)
		C2H2 Zn finger	634..654	CDD:275368	7/19 (37%)
		C2H2 Zn finger	662..682	CDD:275368	6/19 (32%)
		C2H2 Zn finger	690..710	CDD:275368	7/20 (35%)
		C2H2 Zn finger	718..738	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900