DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF605

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001158187.1	Gene:	ZNF605 / 100289635	HGNCID:	28068	Length:	672	Species:	Homo sapiens

Alignment Length:	442	Identity:	173/442 - (39%)
Similarity:	251/442 - (56%)	Gaps:	8/442 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 PSKLKTCKSKIAKKRPLRKQTDTFK------CTQCQKTFTRKENLESHLRLHAEERPFECSHCSK 117
            |.:...|....::|..|.....|..      |::|||.|:||..|..|.|:|..|:|:.||.|.|
Human   227 PYQCSECGKAFSQKSLLTVHQRTHSGEKPHGCSECQKAFSRKSLLILHQRIHTGEKPYGCSECGK 291

  Fly   118 SFGRRTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQ 181
            :|.|::..|||.:.|. ::|:.||.|.|.|:|...|..|...||||:|:.|:.|..:|..||.|.
Human   292 AFSRKSQLKRHQITHTIEKPYSCSECGKAFSQKLKLITHQRAHTGEKPYPCSHCGKAFFWKSQLI 356

  Fly   182 VHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AE 245
            .|.|||:.::|:.|..|:|||..||.|..|.|.|...:|::|:.|.::|..:..|.||.:|| .|
Human   357 THQRTHTGKKPYGCGECQKAFSRNSLLIRHQRIHTGEKPYECNECGEAFIRKPQLIKHQITHTGE 421

  Fly   246 RSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCS 310
            ::::|:.|.:.|.:...|..|.::|.||.|:.|..|.:||...|:|..|...|.|::|.:||:|.
Human   422 KNYRCSDCEEAFFKKSELIRHQKIHLGEKPYGCIQCGKTFFGKSQLLTHHRTHTGEKPYECSECG 486

  Fly   311 ATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHL 375
            ..|..:|....|.|.||.|:.|:|:||.|:|.:||.|:.||:.||||:||:|:.|.|.|..:..|
Human   487 KAFTQKSSLISHQRTHTGEKPYECSECRKTFSEKSSLIHHQRTHTGEKPFECSECRKAFAWKPQL 551

  Fly   376 RVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTG 440
            ..|...|.|||..:||.|.|.|....||:.|.:.|||:..:.|..|:|::...:.|.:|.|.|||
Human   552 LRHQRIHTGEKPYECSECGKAFVQKVQLIKHQRNHTGEKTYGCSDCAKAFFEKAQLIIHQRIHTG 616

  Fly   441 ELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            |.|:||..|.|.|.|.:....|.|.|||:|.|.|:.|.|.:.:||.|..|.|
Human   617 ERPYKCGECGKSFTRKSHLMRHQRIHTGDKYYGCNECGTTFNRKSQLMIHQR 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	163/411 (40%)
		C2H2 Zn finger	84..104	CDD:275368	10/19 (53%)
		C2H2 Zn finger	112..132	CDD:275368	9/19 (47%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	11/24 (46%)
		C2H2 Zn finger	195..215	CDD:275368	10/19 (53%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	5/19 (26%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	7/17 (41%)
ZNF605	NP_001158187.1	C2H2 Zn finger	566..586	CDD:275368	8/19 (42%)
		C2H2 Zn finger	594..614	CDD:275368	6/19 (32%)
		zf-H2C2_2	607..631	CDD:290200	13/23 (57%)
		zf-C2H2	620..642	CDD:278523	8/21 (38%)
		C2H2 Zn finger	622..642	CDD:275368	7/19 (37%)
		C2H2 Zn finger	650..670	CDD:275368	8/19 (42%)
		KRAB	7..65	CDD:214630
		KRAB	7..45	CDD:279668
		C2H2 Zn finger	176..196	CDD:275368
		COG5048	199..603	CDD:227381	144/375 (38%)
		C2H2 Zn finger	202..222	CDD:275368
		zf-H2C2_2	215..239	CDD:290200	2/11 (18%)
		C2H2 Zn finger	230..250	CDD:275368	3/19 (16%)
		C2H2 Zn finger	258..278	CDD:275368	10/19 (53%)
		C2H2 Zn finger	286..306	CDD:275368	9/19 (47%)
		zf-H2C2_2	299..323	CDD:290200	10/23 (43%)
		C2H2 Zn finger	314..334	CDD:275368	8/19 (42%)
		C2H2 Zn finger	342..362	CDD:275368	8/19 (42%)
		C2H2 Zn finger	370..390	CDD:275368	10/19 (53%)
		zf-H2C2_2	383..407	CDD:290200	8/23 (35%)
		C2H2 Zn finger	398..418	CDD:275368	6/19 (32%)
		C2H2 Zn finger	426..446	CDD:275368	5/19 (26%)
		C2H2 Zn finger	454..474	CDD:275368	7/19 (37%)
		zf-H2C2_2	467..491	CDD:290200	9/23 (39%)
		C2H2 Zn finger	482..502	CDD:275368	7/19 (37%)
		zf-H2C2_2	494..518	CDD:290200	10/23 (43%)
		C2H2 Zn finger	510..530	CDD:275368	10/19 (53%)
		zf-H2C2_2	522..546	CDD:290200	12/23 (52%)
		C2H2 Zn finger	538..558	CDD:275368	6/19 (32%)
		zf-H2C2_2	551..575	CDD:290200	11/23 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810