DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF737

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_005259754.1	Gene:	ZNF737 / 100129842	HGNCID:	32468	Length:	551	Species:	Homo sapiens

Alignment Length:	463	Identity:	172/463 - (37%)
Similarity:	244/463 - (52%)	Gaps:	14/463 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 CS-YGKDLEPVKGVPSKLKTCKSKIAKKRPLRKQTDTFKCTQ-CQ-----KTFTRKENLESHLRL 103
            || :.:||.|.:.:    |....|:..:|......|..:..: |:     |...|..|..:....
Human    78 CSHFARDLWPEQSI----KDSFQKVTLRRYENYGHDNLQFKKGCESVDECKVHKRGYNGLNQYLT 138

  Fly   104 HAEERPFECSHCSKSFGRRTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKC 167
            ..:.:.|:|....|...:.::..||.::|. |:|.||..|.|.|.|:|:|..|...||||:||||
Human   139 TTQSKIFQCDKYVKVIHKFSNSNRHKIRHTGKKPFKCIECGKAFNQSSTLTTHKKIHTGEKPFKC 203

  Fly   168 TQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKL 232
            .:|..:|...|||..|.|.|:.|:.::|..|.|||...|:|..|...|...:|:||..|.|:||.
Human   204 EECGKAFNWSSHLTTHKRIHTGEKRYKCEDCGKAFSRFSYLTAHKIIHSGEKPYKCEECGKAFKR 268

  Fly   233 RSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLL 296
            .|.|..|.:.| .|:.:||.:|.|.|.::..|..|..:|:||.|:||..|.:.|...|.|..|..
Human   269 SSNLTTHKIIHTGEKPYKCEECGKAFKRSSILTAHKIIHSGEKPYKCEECGKAFKHPSVLTTHKR 333

  Fly   297 EHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFK 361
            .|.|::|.||.:|...|...|....|..:|:.|:.|||.||.|:|...|||..|:::||||:|:|
Human   334 IHTGEKPYKCEECGRAFKYFSSLTTHKIIHSGEKPYKCEECGKAFNWSSHLTTHKRIHTGEKPYK 398

  Fly   362 CTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYT 426
            |..|.:.||..:.|..|.:.|.|::..||..|.|.||..|.|..|.:.|||:..::|..|.|::.
Human   399 CEECGEAFKYSSSLTTHKIIHTGQQPFKCEECGKAFKCFSILTTHKRIHTGEKPYKCEECGKAFN 463

  Fly   427 TSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHL 491
            :||.|..|.|.||||.|:||..|.|.|.||.....|.|.|||||||||..|...:...|:|..|
Human   464 SSSHLTAHKRIHTGEKPYKCERCGKAFKRSFILTRHKRIHTGEKPYKCEECGKGFKCPSTLTTH- 527

  Fly   492 RRTLCGTK 499
            :|:.|.|:
Human   528 KRSGCPTR 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	157/411 (38%)
		C2H2 Zn finger	84..104	CDD:275368	4/25 (16%)
		C2H2 Zn finger	112..132	CDD:275368	4/19 (21%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	11/24 (46%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
ZNF737	XP_005259754.1	KRAB	4..62	CDD:214630
		KRAB	6..43	CDD:279668
		COG5048	143..528	CDD:227381	156/385 (41%)
		zf-H2C2_2	159..184	CDD:290200	10/24 (42%)
		C2H2 Zn finger	175..195	CDD:275368	8/19 (42%)
		zf-H2C2_2	188..211	CDD:290200	11/22 (50%)
		C2H2 Zn finger	203..223	CDD:275368	8/19 (42%)
		zf-H2C2_2	215..240	CDD:290200	11/24 (46%)
		C2H2 Zn finger	231..251	CDD:275368	8/19 (42%)
		zf-H2C2_2	243..268	CDD:290200	9/24 (38%)
		C2H2 Zn finger	259..279	CDD:275368	8/19 (42%)
		zf-H2C2_2	271..296	CDD:290200	9/24 (38%)
		C2H2 Zn finger	287..307	CDD:275368	6/19 (32%)
		zf-H2C2_2	300..324	CDD:290200	10/23 (43%)
		C2H2 Zn finger	315..335	CDD:275368	6/19 (32%)
		zf-H2C2_2	328..352	CDD:290200	9/23 (39%)
		C2H2 Zn finger	343..363	CDD:275368	5/19 (26%)
		zf-H2C2_2	355..379	CDD:290200	9/23 (39%)
		C2H2 Zn finger	371..391	CDD:275368	9/19 (47%)
		zf-H2C2_2	383..408	CDD:290200	12/24 (50%)
		C2H2 Zn finger	399..419	CDD:275368	6/19 (32%)
		C2H2 Zn finger	427..447	CDD:275368	8/19 (42%)
		zf-H2C2_2	440..464	CDD:290200	8/23 (35%)
		C2H2 Zn finger	455..475	CDD:275368	8/19 (42%)
		zf-H2C2_2	467..492	CDD:290200	13/24 (54%)
		C2H2 Zn finger	483..503	CDD:275368	8/19 (42%)
		zf-H2C2_2	496..520	CDD:290200	12/23 (52%)
		C2H2 Zn finger	511..529	CDD:275368	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810