DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and Rex2

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001171238.1	Gene:	Rex2 / 100043034	MGIID:	1328322	Length:	685	Species:	Mus musculus

Alignment Length:	411	Identity:	174/411 - (42%)
Similarity:	243/411 - (59%)	Gaps:	2/411 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 FKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHE-KRPHKCSHCSKT 145
            :||::|.|.||.|..|..|.|:|..|:|::||.|.|.|..:...::|...|. ::|:||:.|.|.
Mouse   251 YKCSECDKCFTDKCTLRKHQRIHTGEKPYKCSECDKCFTDKCTLRKHQRIHTGEKPYKCNECDKC 315

  Fly   146 FTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQE 210
            ||...||:.|...||||:|:||::|...|.:.|||.:|.|.||.|:|::|:.|:|.|.:...|::
Mouse   316 FTDKGSLRVHQRIHTGEKPYKCSECDKCFTQPSHLSIHRRIHSGEKPYKCSECDKCFTDKCTLRK 380

  Fly   211 HLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGED 274
            |.|.|...:|:|||.|.|.|..:..|:||...| .|:.:||.:|.|.|....||::|.|:|.||.
Mouse   381 HQRIHTGEKPYKCSECDKCFTEKFTLRKHQRIHTGEKPYKCNECDKCFTDKGSLRVHQRIHTGEK 445

  Fly   275 PFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSK 339
            |:||..|.:.|.:.|.|.:|...|:|::|.|||:|...|...|...:|.|:|:.|:.|||:||.|
Mouse   446 PYKCSECDKCFTKPSHLSIHRRIHSGEKPYKCSECDKCFTQPSPLSIHRRIHSGEKPYKCSECDK 510

  Fly   340 SFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLL 404
            .|..|..|..||::|.||:|:||:.|.|.|...:||.:|...|.|||..|||.|.|.|.....|.
Mouse   511 CFTDKGSLRVHQRIHIGEKPYKCSECDKCFTQPSHLSIHCRIHSGEKPYKCSECDKCFTHKGSLR 575

  Fly   405 VHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGE 469
            ||.:.|.|:..::|..|.|.:|..:.|..|.|.||||.|:|||.|.|.|.|.:....|.|.||||
Mouse   576 VHHRIHAGEKPYKCSECDKCFTEKNGLRRHQRIHTGEKPYKCSECDKCFTRKSHLSIHQRIHTGE 640

  Fly   470 KPYKCSHCSTRYTQKSSLGRH 490
            |.||||.|...:||:..|..|
Mouse   641 KLYKCSECDKCFTQQCHLSIH 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	169/397 (43%)
		C2H2 Zn finger	84..104	CDD:275368	9/19 (47%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..492	CDD:275368	7/17 (41%)
Rex2	NP_001171238.1	KRAB	27..67	CDD:366587
		C2H2 Zn finger	197..217	CDD:275368
		C2H2 Zn finger	229..245	CDD:275368
		C2H2 Zn finger	253..273	CDD:275368	9/19 (47%)
		COG5048	277..666	CDD:227381	162/385 (42%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		C2H2 Zn finger	309..329	CDD:275368	8/19 (42%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		C2H2 Zn finger	365..385	CDD:275368	7/19 (37%)
		C2H2 Zn finger	393..413	CDD:275368	8/19 (42%)
		C2H2 Zn finger	421..441	CDD:275368	8/19 (42%)
		C2H2 Zn finger	449..469	CDD:275368	6/19 (32%)
		C2H2 Zn finger	477..497	CDD:275368	7/19 (37%)
		C2H2 Zn finger	505..525	CDD:275368	9/19 (47%)
		C2H2 Zn finger	533..553	CDD:275368	7/19 (37%)
		C2H2 Zn finger	561..581	CDD:275368	8/19 (42%)
		C2H2 Zn finger	589..609	CDD:275368	7/19 (37%)
		C2H2 Zn finger	617..637	CDD:275368	8/19 (42%)
		C2H2 Zn finger	645..665	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900