DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5641 and ZFR

DIOPT Version :9

Sequence 1:	NP_650196.1	Gene:	CG5641 / 41529	FlyBaseID:	FBgn0038046	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_057191.2	Gene:	ZFR / 51663	HGNCID:	17277	Length:	1074	Species:	Homo sapiens

Alignment Length:	403	Identity:	93/403 - (23%)
Similarity:	172/403 - (42%)	Gaps:	92/403 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 PKVPSAGAVDDSALTAALLKRNQDLSPTPSEQTAIGNLVTKVQAVLDNLVVAPGDLTTCQLEE-- 102
            |:.|:.....||:....::.::..:.||..|..|:..:|:..:..|        .|.:..|.|
Human   710 PQGPAPLRRPDSSDDRYVMTKHATIYPTEEELQAVQKIVSITERAL--------KLVSDSLSEHE 766

  Fly   103 ---------------------VRQVGSFKKGTILTGNNVADVVVILKTLPTKEAVDALAKKV--- 143
                                 |.:||...||.:|.|:...::|::....|:|..:..:|:.:
Human   767 KNKNKEGDDKKEGGKDRALKGVLRVGVLAKGLLLRGDRNVNLVLLCSEKPSKTLLSRIAENLPKQ 831

  Fly   144 -------EADLKASMKTEVLTKGDQHTVQIHERGFDIAN--VHAKVRILIA-TLP----QNLR-- 192
                   :.|:|.::....:                |.|  |..|:::.|. |.|    :|:|
Human   832 LAVISPEKYDIKCAVSEAAI----------------ILNSCVEPKMQVTITLTSPIIREENMREG 880

  Fly   193 -------KLEPEIHLDHKLMQSHLAAIRHTRWFEENAHH-SSIKVLIRILKDLTRRFDAFSPLSA 249
                   |..|:: ||.:.....|||:||.:||:..|:. .|..::||||:||.:|...:|...:
Human   881 DVTSGMVKDPPDV-LDRQKCLDALAALRHAKWFQARANGLQSCVIIIRILRDLCQRVPTWSDFPS 944

  Fly   250 WMLDLIAHLAIMNNPSRQALPINLAFRRVFQLLSAGLFLPGSAGITDPTEPGHIRVHTAMTLEQQ 314
            |.::|:...||.:..|.|: |.: |.||||:.:|:|:.|.||.|:.||.|.........||.:|:
Human   945 WAMELLVEKAISSASSPQS-PGD-ALRRVFECISSGIILKGSPGLLDPCEKDPFDTLATMTDQQR 1007

  Fly   315 DVCCYTSQTLLRVLAHGGYKHILGLEGNTSVVREMSVWNGVCISPLTAVYEKPTDKKEGDLEEDI 379
            :....::|..||:||......:||::....:.:..::.|               ::|.....:.:
Human  1008 EDITSSAQFALRLLAFRQIHKVLGMDPLPQMSQRFNIHN---------------NRKRRRDSDGV 1057

  Fly   380 DMIENENEEEGSD 392
            |..|.|.:::..|
Human  1058 DGFEAEGKKDKKD 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5641	NP_650196.1	DZF	105..345	CDD:284860	73/266 (27%)
ZFR	NP_057191.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..139
		ZnF_U1	331..360	CDD:197732
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..377
		ZnF_U1	384..413	CDD:197732
		Epiglycanin_TR	420..477	CDD:283334
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	421..447
		ZnF_U1	581..612	CDD:197732
		C2H2 Zn finger	584..606	CDD:275371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	702..723		4/12 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	761..781		2/19 (11%)
		DZF	784..1038	CDD:128842	74/272 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1040..1074		6/46 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810