DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5641 and ILF3

DIOPT Version :9

Sequence 1:	NP_650196.1	Gene:	CG5641 / 41529	FlyBaseID:	FBgn0038046	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_001381737.1	Gene:	ILF3 / 3609	HGNCID:	6038	Length:	898	Species:	Homo sapiens

Alignment Length:	382	Identity:	100/382 - (26%)
Similarity:	161/382 - (42%)	Gaps:	78/382 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 LLKRNQDLSPTPSEQTAIGNLVTKV--------------------QAVLDNLVVAPGDLT----- 96
            ::.::..:.||..|..|:.|:|:..                    ||..||:.|.|.|.:
Human    14 VMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQAESDNMDVPPEDDSKEGAG 78

  Fly    97 -------TCQLEEVRQVGSFKKGTILTGNNVADVVVILKTLPTKEAVDALAKKVEADLKA--SMK 152
                   |..|..|.:||...||.:|.|:...::|::.|..||...:|.:|..:...|.|  ..|
Human    79 EQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLAAVTEDK 143

  Fly   153 TEVL------------TKGDQHTVQIHERGFDIANVHAKVRILIATLPQNLRKLEPEIHLDHKLM 205
            .|:|            ||....::.||.....:.....|| :...||..|    :|...||.:..
Human   144 YEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEMEKV-LAGETLSVN----DPPDVLDRQKC 203

  Fly   206 QSHLAAIRHTRWFEENAHH-SSIKVLIRILKDLTRRFDAFSPLSAWMLDLIAHLAI--MNNPSRQ 267
            .:.||::||.:||:..|:. .|..::||:|:||..|...:.||..|.|:|:...:|  .|.|
Human   204 LAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRP--- 265

  Fly   268 ALPINLAFRRVFQLLSAGLFLPGSAGITDPTEP------GHIRVHTAMTLEQQDVCCYTSQTLLR 326
             :....|.|||.:.|::|:.:|..:||.||.|.      ||      :..:|::....::|..||
Human   266 -MGAGEALRRVLECLASGIVMPDGSGIYDPCEKEATDAIGH------LDRQQREDITQSAQHALR 323

  Fly   327 VLAHGGYKHILGLEGNTSVV-----REMSVWNGVCISPLTAVYEKPTDKKEGDLEED 378
            :.|.|....:||::...|.:     .|..|...|.|.|.|.....|..:   .:|||
Human   324 LAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKR---PMEED 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5641	NP_650196.1	DZF	105..345	CDD:284860	73/262 (28%)
ILF3	NP_001381737.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..86		7/35 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..401		5/18 (28%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	371..389		3/10 (30%)
		Interaction with PRMT1. /evidence=ECO:0000269\|PubMed:10749851	613..898
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	629..664
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	722..898
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810