DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5641 and ILF2

DIOPT Version :9

Sequence 1:	NP_650196.1	Gene:	CG5641 / 41529	FlyBaseID:	FBgn0038046	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_004506.2	Gene:	ILF2 / 3608	HGNCID:	6037	Length:	390	Species:	Homo sapiens

Alignment Length:	401	Identity:	224/401 - (55%)
Similarity:	287/401 - (71%)	Gaps:	22/401 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RGALRGGR------PMRGGIRPPFKKTFVPRHPFDLTLAEVFFPKVPSAGAVDDSALTAALLKRN 61
            ||..||||      | .||.||     |||..|||..|.|:.||:|..  |.|:::.:.||||||
Human     5 RGRGRGGRFGSRGGP-GGGFRP-----FVPHIPFDFYLCEMAFPRVKP--APDETSFSEALLKRN 61

  Fly    62 QDLSPTPSEQTAIGNLVTKVQAVLDNLVVAPGDLTTCQLEEVRQVGSFKKGTILTGNNVADVVVI 126
            |||:|..:||.:|.:||||:..|:|||:||||.... |:||||||||:||||:.||:||||:|||
Human    62 QDLAPNSAEQASILSLVTKINNVIDNLIVAPGTFEV-QIEEVRQVGSYKKGTMTTGHNVADLVVI 125

  Fly   127 LKTLPTKEAVDALAKKVEADLKASMKTEVLTKGDQHTVQIHERGFDIANVHAKVRILIATLPQNL 191
            ||.|||.|||.||..||...|:|...:|||      |:..:|.||:|::..|.|:|||.|:|.||
Human   126 LKILPTLEAVAALGNKVVESLRAQDPSEVL------TMLTNETGFEISSSDATVKILITTVPPNL 184

  Fly   192 RKLEPEIHLDHKLMQSHLAAIRHTRWFEENAHHSSIKVLIRILKDLTRRFDAFSPLSAWMLDLIA 256
            |||:||:|||.|::||.||||||.|||||||..|::|||||:||||..||..|.||:.|:|||:.
Human   185 RKLDPELHLDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPLTPWILDLLG 249

  Fly   257 HLAIMNNPSRQALPINLAFRRVFQLLSAGLFLPGSAGITDPTEPGHIRVHTAMTLEQQDVCCYTS 321
            |.|:||||:||.|.:|:|:||..|:|:||||||||.|||||.|.|:.||||.|||||||:.|||:
Human   250 HYAVMNNPTRQPLALNVAYRRCLQILAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTA 314

  Fly   322 QTLLRVLAHGGYKHILGLEGNTS-VVREMSVWNGVCISPLTAVYEKPTDKKEGDLEEDIDMIENE 385
            |||:|:|:|||::.|||.||:.| :..|:|.|:||.::|....||||.:||||:.||:......:
Human   315 QTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEKPPEKKEGEEEEENTEEPPQ 379

  Fly   386 NEEEGSDDGAE 396
            .|||.|.:..|
Human   380 GEEEESMETQE 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5641	NP_650196.1	DZF	105..345	CDD:284860	149/240 (62%)
ILF2	NP_004506.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		7/15 (47%)
		DZF	98..338	CDD:128842	153/245 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..390		15/38 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154955
Domainoid	1	1.000	299	1.000	Domainoid score	I1443
eggNOG	1	0.900	-	-		E1_KOG3792
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H26894
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1844
Isobase	1	0.950	-	0	Normalized mean entropy	S3337
OMA	1	1.010	-	-		QHG48618
OrthoDB	1	1.010	-	-		D1145212at2759
OrthoFinder	1	1.000	-	-		FOG0006953
OrthoInspector	1	1.000	-	-		oto88849
orthoMCL	1	0.900	-	-		OOG6_107734
Panther	1	1.100	-	-	LDO	PTHR46447
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3592
SonicParanoid	1	1.000	-	-		X5046
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750