DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5641 and zfr

DIOPT Version :9

Sequence 1:	NP_650196.1	Gene:	CG5641 / 41529	FlyBaseID:	FBgn0038046	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_955852.2	Gene:	zfr / 321659	ZFINID:	ZDB-GENE-030131-378	Length:	1074	Species:	Danio rerio

Alignment Length:	434	Identity:	104/434 - (23%)
Similarity:	180/434 - (41%)	Gaps:	102/434 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GRPMRGGIRPPFKKTFVPRHPFDLTLAEVFFPKVPSAGAVDDSALTAALLKRNQDLSPTPSEQTA 73
            |.|...|:||...   :|:            |:.|......||:....::.::..:.|:..|..|
Zfish   689 GPPGLLGVRPGMP---IPQ------------PQGPVPPRRPDSSDDRYVMTKHAAIYPSEDELQA 738

  Fly    74 IGNLVTKVQAVLDNLVVAPGDLTTCQ-----------------------LEEVRQVGSFKKGTIL 115
            |..:|:..:..| .||   .|:.|.|                       |:.|.:||...||.:|
Zfish   739 IQKIVSITERAL-KLV---SDIITDQDAGASAKGKEEDKEKKEPPKDRLLKGVMRVGVLAKGLLL 799

  Fly   116 TGNNVADVVVILKTLPTK----EAVDALAKKV------EADLKASMKTE--VLTK-GD---QHTV 164
            .|:...::|::....|||    ..|:.|.|::      :.::|.|::..  :||. ||   |.|:
Zfish   800 RGDKEVNLVLLCSEKPTKNLLTRIVEHLPKQLTMVTPEKYEVKGSIQESAIILTSCGDPKMQVTI 864

  Fly   165 QI--------HERGFDIANVHAKVRILIATLPQNLRKLEPEIHLDHKLMQSHLAAIRHTRWFEEN 221
            .:        ..|..|:.:...|               :|...||.:.....|||:||.:||:..
Zfish   865 TLTSPIIREESSRDGDVTSSMVK---------------DPADVLDRQKCLDALAALRHAKWFQAR 914

  Fly   222 AHH-SSIKVLIRILKDLTRRFDAFSPLSAWMLDLIAHLAIMNNPSRQALPINL--AFRRVFQLLS 283
            |:. .|..::||||:||.:|...:|...:|.::|:...||    |..:.|::.  |.||||:.:|
Zfish   915 ANGLQSCVIVIRILRDLCQRVPTWSAFPSWAMELLVEKAI----SSASGPMSPGDALRRVFECIS 975

  Fly   284 AGLFLPGSAGITDPTEPGHIRVHTAMTLEQQDVCCYTSQTLLRVLAHGGYKHILGLEGNTSVVRE 348
            :|:.|.|:.|:.||.|.........|..:|::....::|..||:||......:||::....:...
Zfish   976 SGILLSGAPGLIDPCEKNPTDTLAFMEEQQREDITSSAQFALRLLAFRQIHKVLGMDPLPQMNSR 1040

  Fly   349 MSVWNGVCISPLTAVYEKPTDKKEGDLEEDIDMIENENEEEGSD 392
            .:|.|              |.|:..|..:..|..|.|.:::..|
Zfish  1041 FNVRN--------------TRKRRRDNSDGADGFEAEGKKDKKD 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5641	NP_650196.1	DZF	105..345	CDD:284860	72/266 (27%)
zfr	NP_955852.2	ZnF_U1	324..353	CDD:197732
		C2H2 Zn finger	326..348	CDD:275371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..374
		ZnF_U1	380..409	CDD:197732
		C2H2 Zn finger	380..402	CDD:275371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..456
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..545
		ZnF_U1	575..606	CDD:197732
		C2H2 Zn finger	578..600	CDD:275371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..718		7/35 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	761..781		0/19 (0%)
		DZF	784..1037	CDD:128842	74/271 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1036..1074		9/49 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810