DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5641 and ZFR2

DIOPT Version :9

Sequence 1:	NP_650196.1	Gene:	CG5641 / 41529	FlyBaseID:	FBgn0038046	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	XP_011526133.1	Gene:	ZFR2 / 23217	HGNCID:	29189	Length:	940	Species:	Homo sapiens

Alignment Length:	352	Identity:	86/352 - (24%)
Similarity:	152/352 - (43%)	Gaps:	73/352 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 PKVPSAGAVDDSALTAA-----LLKRNQDLSPTPSE----QTAIGNLVTKVQAVLDNLV------ 89
            |:.|::..:......|:     ::.::..:.||..|    |.|:.:....::.|.|.|.
Human   571 PESPASAPLQPGRRPASSDDRHVMCKHATIYPTEQELLAVQRAVSHAERALKLVSDTLAEEDRGR 635

  Fly    90 ----------VAPGDLTTCQLEEVRQVGSFKKGTILTGNNVADVVVILKTLPTKEAVDALAKKVE 144
                      |||   .|..|:.|.:||...||.:|.|:....:.::....||...:..:|:::.
Human   636 REEEGDKRSSVAP---QTRVLKGVMRVGILAKGLLLRGDRNVRLALLCSEKPTHSLLRRIAQQLP 697

  Fly   145 ADLKASMKTEVLTKGDQHTVQIHERGFDIANV------HAKVRILI-----------ATLPQNLR 192
            ..|:  |.||     |::.|.....    ||:      ..::::.|           :|.|:.:.
Human   698 RQLQ--MVTE-----DEYEVSSDPE----ANIVISSCEEPRMQVTISVTSPLMREDPSTDPEGVE 751

  Fly   193 KLEPEIH----LDHKLMQSHLAAIRHTRWFEENAHHSSIK---VLIRILKDLTRRFDAFSPLSAW 250
              ||:..    |..|.....|||:||.|||:..|  |.::   ::||:|:||.||...:..|.||
Human   752 --EPQADAGDVLSPKKCLESLAALRHARWFQARA--SGLQPCVIVIRVLRDLCRRVPTWGALPAW 812

  Fly   251 MLDLIAHLAIMNNPSRQALPINL--AFRRVFQLLSAGLFLPGSAGITDPTEPGHIRVHTAMTLEQ 313
            .::|:...|:    |..|.|:..  |.|||.:.::.|..|....|:.||.|.........|||::
Human   813 AMELLVEKAV----SSAAGPLGPGDAVRRVLECVATGTLLTDGPGLQDPCERDQTDALEPMTLQE 873

  Fly   314 QDVCCYTSQTLLRVLAHGGYKHILGLE 340
            ::....::|..||:||......:||::
Human   874 REDVTASAQHALRMLAFRQTHKVLGMD 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5641	NP_650196.1	DZF	105..345	CDD:284860	69/262 (26%)
ZFR2	XP_011526133.1	ZnF_U1	271..300	CDD:197732
		C2H2 Zn finger	273..295	CDD:275371
		ZnF_U1	318..350	CDD:197732
		C2H2 Zn finger	321..343	CDD:275371
		ZnF_U1	467..498	CDD:197732
		C2H2 Zn finger	470..492	CDD:275371
		DZF	652..905	CDD:128842	71/268 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810