DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pps and SPOCD1

DIOPT Version :10

Sequence 1:NP_001247075.1 Gene:pps / 41524 FlyBaseID:FBgn0082831 Length:2018 Species:Drosophila melanogaster
Sequence 2:NP_653170.3 Gene:SPOCD1 / 90853 HGNCID:26338 Length:1216 Species:Homo sapiens


Alignment Length:1333 Identity:283/1333 - (21%)
Similarity:432/1333 - (32%) Gaps:444/1333 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   736 VSMPTSIEPVDVPQVQAHTNLLPNASLTEPAQSMTSLPIACSTPSRSVAASTPPTSAKVVRGYGR 800
            |..|::.:||..||   |     |..|.:..:..:|:|        .::...|..|:        
Human     7 VEGPSTGDPVLSPQ---H-----NCELLQNMEGASSMP--------GLSPDGPGASS-------- 47

  Fly   801 VIYLPPIEAPTTRAKRRAQFPSAPGMAATSSSDAGNLSFGESSLDASINQPLNTSSLSNDSQPGS 865
                    .|..||..|.:.|....:...||..||........|:      |.....|..|....
Human    48 --------GPGVRAGSRRKIPRKEALRGGSSRAAGAAEVRPGVLE------LLAVVQSRGSMLAP 98

  Fly   866 GPKRPNPREPSMARRSTAPRRSKKLDASQNNDPDASESQEDDDDPNKLWCICRQPHNNRFMICCD 930
            |.....|..|:..|..|    ||:|..|..:       ..||..|.|| |........|.:.|.:
Human    99 GLHMQLPSVPTQGRALT----SKRLQVSLCD-------ILDDSCPRKL-CSRSAGLPERALACRE 151

  Fly   931 LCEDWFHGTCVGVTKAMGTDMENKGIDWKCPKCVKRQEERSQPRITDMLVTRPTTQP-------- 987
            ........:|:...:|....|.:.|.|.:.| .:.::|...:|     |.:.|...|        
Human   152 RLAGVEEVSCLRPREARDGGMSSPGCDRRSP-TLSKEEPPGRP-----LTSSPDPVPVRVRKKWR 210

  Fly   988 ------------------EQRPSETKVLTTTAEIVQVAAPSAPRRTLPVVLTVAS--SPMRIPMA 1032
                              :|.|....:|:       |..|       |.|..:.|  .|.|.|..
Human   211 RQGAHSECEEGAGDFLWLDQSPRGDNLLS-------VGDP-------PQVADLESLGGPCRPPSP 261

  Fly  1033 K-----PAKKFPTGAISHQQQQQLNFIRL---GPSPGKRI----------SETLCVVCKRPASTS 1079
            |     |.:...:||......::..::..   ||.||...          .|:|....:.|..::
Human   262 KDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSPCGPVGFPVPSGGESLSSAAQAPPQSA 326

  Fly  1080 SVYCGEECIRKYAQSAIQAHAAT----KGPLPQNAGAQSLLNNSFDAKKNKKKDLFEDVLRQADT 1140
            ::     |:...||::.:...|.    .|.....|.||........|:...:..|.:.:...|||
Human   327 AL-----CLGASAQASAEQQEAVCVVRTGSDEGQAPAQDQEELEAKAQPASRGRLEQGLAAPADT 386

  Fly  1141 -VSKVERI----NVFERKSGRVITGHMAPSAHQFR----KWLQENPSFEVLPSGTVQSADAEKRL 1196
             .|..|.:    :..:.::.|..:|   |...|.|    |.|::.|.......||.:|:|...  
Human   387 CASSREPLGGLSSSLDTEASRACSG---PFMEQRRSKGTKNLKKGPVPCAQDRGTDRSSDNSH-- 446

  Fly  1197 LKGAPEAATSTSEPAVLGVAK----KPPEGP---------------AKLSHPQNTTVQASHQL-- 1240
             :..||      ||:..|..:    |.|.|.               ..:||.     ||..||  
Human   447 -QDRPE------EPSPGGCPRLEEVKIPHGVKLVCYLGSGPVIQLLGAISHG-----QAGGQLPP 499

  Fly  1241 ---------GISSVRPLAKKDKEKTTPTVQA--------PTPNRIAAGKP--------------- 1273
                     .:||..| |::.:.|..|.||.        |:|:...||.|               
Human   500 KLEVLEDLMEVSSPSP-AQRLRRKKRPMVQGPAGCQVFQPSPSGGTAGDPGGLSDPFYPPRSGSL 563

  Fly  1274 --------------------------EP------------VRIGIR----RSLREQLLARIKEAQ 1296
                                      :|            :.||:|    ||::|.|..|::|..
Human   564 ALGDPSSDPACSQSGPMEAEEDSLPEQPEDSAQLQQEKPSLYIGVRGTVVRSMQEVLWTRLRELP 628

  Fly  1297 AAEENSGQPTTQWPTVLE--VDQFVKNVELEMFNSFGRDVGAKYKAKYRSLMFNIKDRKNRTLFE 1359
            .            |.:.|  |:.....:|..::: ..:....:||.|||||:||::|.:|..||.
Human   629 D------------PVLSEEVVEGIAAGIEAALWD-LTQGTNGRYKTKYRSLLFNLRDPRNLDLFL 680

  Fly  1360 KICAKQVEPRQLVRMTPEQLASQELAKWREEENRHQLDMIKKSELDLLACAQNYVVKTHKGEEVI 1424
            |:....|.|..||||:..|||.||||:||::|.:..|::|::.:.:  .|.......|||||..|
Human   681 KVVHGDVTPYDLVRMSSMQLAPQELARWRDQEEKRGLNIIEQQQKE--PCRLPASKMTHKGEVEI 743

  Fly  1425 ATKVDVTLPEENVSEASSMADTKQTSL--VSEPSTSTLERSTSREKAGSSKEKRHKSHKHH---- 1483
            ...:|.||..|::.......|....:|  .||.:|.                    .|.||    
Human   744 QRDMDQTLTLEDLVGPQMFMDCSPQALPIASEDTTG--------------------QHDHHFLDP 788

  Fly  1484 --HRKRSRSRSNSRGRSVDKRHRRQHNEGGEQPGSGEREHRSREKQSRERDEIVPSPLPKKRDEN 1546
              |..:....||                  |..||.|.....       .|.|....|       
Human   789 NCHICKDWEPSN------------------ELLGSFEAAKSC-------GDNIFQKAL------- 821

  Fly  1547 DQSPVPKKTAEKKTEASAYNLVDQILESEKTVEQAANLGKPKPSPKPLPTLPSSLKAPEPMDNYS 1611
            .|:|:|.....|..|.|.....|::..|        .|..|....|.||.||.            
Human   822 SQTPMPAPEMPKTRELSPTEPQDRVPPS--------GLHVPAAPTKALPCLPP------------ 866

  Fly  1612 RYLHGLTTSSLWSGTLKMIDLADFEIVMYPVQGNCHQLGNLMPSQMDVIGRITRVNVWEYIKKLK 1676
                       |.|.|.|..:..|......|.|:..:|...:|:.:...|.|....||:.:..:.
Human   867 -----------WEGVLDMFSIKRFRARAQLVSGHSCRLVQALPTVIRSAGCIPSNIVWDLLASIC 920

  Fly  1677 KSPTKEVVIVNIFPASPSETYKFDLFFEYLDSRQRLGVLGVDSDQIRDFYIFPLGSGDKLPPALQ 1741
            .:..|:|.:|.:.|....:|....|.:.||:.|||.|:..|:.   ....:.||.:...||..|:
Human   921 PAKAKDVCVVRLCPHGARDTQNCRLLYSYLNDRQRHGLASVEH---MGMVLLPLPAFQPLPTRLR 982

  Fly  1742 T-------AEPV-PFYE---EAQRPNTLLGIIVRCLSKRPADAVPSTPSVPTPVPALSSKVAKRS 1795
            .       |.|| |...   |....:.||.:::      |.:.:|.|                  
Human   983 PLGGPGLWALPVSPLLSPGLEVTHSSLLLAVLL------PKEGLPDT------------------ 1023

  Fly  1796 RSSISYPAQSSP-----KRKISTHSTSSK-----DDEFDIDAIIKAPIAKLQKTAPKVVPQPSVP 1850
                   |.|||     ::.:|.:|...|     ||.                       :|:||
Human  1024 -------AGSSPWLGKVQKMVSFNSKVEKRYYQPDDR-----------------------RPNVP 1058

  Fly  1851 NDADEPYSPGGSDDE------LVP---SAPQRP 1874
            .....|  |||:..:      :.|   ||.|||
Human  1059 LKGTPP--PGGAWQQSQGRGSIAPRGISAWQRP 1089

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppsNP_001247075.1 DUF3295 641..>914 CDD:403030 39/177 (22%)
TNG2 <827..965 CDD:227367 31/137 (23%)
PHD_PHF3_like 914..963 CDD:277027 9/48 (19%)
BRK 1141..1184 CDD:462196 10/50 (20%)
TFIIS_M 1274..1399 CDD:462184 45/142 (32%)
SPOC_PPS-like 1622..1764 CDD:439214 38/152 (25%)
SPOCD1NP_653170.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..74 20/98 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 166..216 10/55 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 236..325 20/102 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 348..462 28/125 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 511..601 14/90 (16%)
TFIIS_M 608..718 CDD:462184 41/122 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 823..850 8/34 (24%)
SPOC_SPOCD1 866..1016 CDD:439203 38/181 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1046..1140 15/69 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1176..1216
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.