DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pps and SPOCD1

DIOPT Version :9

Sequence 1:	NP_001247075.1	Gene:	pps / 41524	FlyBaseID:	FBgn0082831	Length:	2018	Species:	Drosophila melanogaster
Sequence 2:	NP_653170.3	Gene:	SPOCD1 / 90853	HGNCID:	26338	Length:	1216	Species:	Homo sapiens

Alignment Length:	1333	Identity:	283/1333 - (21%)
Similarity:	432/1333 - (32%)	Gaps:	444/1333 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   736 VSMPTSIEPVDVPQVQAHTNLLPNASLTEPAQSMTSLPIACSTPSRSVAASTPPTSAKVVRGYGR 800
            |..|::.:||..||   |     |..|.:..:..:|:|        .::...|..|:
Human     7 VEGPSTGDPVLSPQ---H-----NCELLQNMEGASSMP--------GLSPDGPGASS-------- 47

  Fly   801 VIYLPPIEAPTTRAKRRAQFPSAPGMAATSSSDAGNLSFGESSLDASINQPLNTSSLSNDSQPGS 865
                    .|..||..|.:.|....:...||..||........|:      |.....|..|....
Human    48 --------GPGVRAGSRRKIPRKEALRGGSSRAAGAAEVRPGVLE------LLAVVQSRGSMLAP 98

  Fly   866 GPKRPNPREPSMARRSTAPRRSKKLDASQNNDPDASESQEDDDDPNKLWCICRQPHNNRFMICCD 930
            |.....|..|:..|..|    ||:|..|..:       ..||..|.|| |........|.:.|.:
Human    99 GLHMQLPSVPTQGRALT----SKRLQVSLCD-------ILDDSCPRKL-CSRSAGLPERALACRE 151

  Fly   931 LCEDWFHGTCVGVTKAMGTDMENKGIDWKCPKCVKRQEERSQPRITDMLVTRPTTQP-------- 987
            ........:|:...:|....|.:.|.|.:.| .:.::|...:|     |.:.|...|
Human   152 RLAGVEEVSCLRPREARDGGMSSPGCDRRSP-TLSKEEPPGRP-----LTSSPDPVPVRVRKKWR 210

  Fly   988 ------------------EQRPSETKVLTTTAEIVQVAAPSAPRRTLPVVLTVAS--SPMRIPMA 1032
                              :|.|....:|:       |..|       |.|..:.|  .|.|.|..
Human   211 RQGAHSECEEGAGDFLWLDQSPRGDNLLS-------VGDP-------PQVADLESLGGPCRPPSP 261

  Fly  1033 K-----PAKKFPTGAISHQQQQQLNFIRL---GPSPGKRI----------SETLCVVCKRPASTS 1079
            |     |.:...:||......::..::..   ||.||...          .|:|....:.|..::
Human   262 KDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSPCGPVGFPVPSGGESLSSAAQAPPQSA 326

  Fly  1080 SVYCGEECIRKYAQSAIQAHAAT----KGPLPQNAGAQSLLNNSFDAKKNKKKDLFEDVLRQADT 1140
            ::     |:...||::.:...|.    .|.....|.||........|:...:..|.:.:...|||
Human   327 AL-----CLGASAQASAEQQEAVCVVRTGSDEGQAPAQDQEELEAKAQPASRGRLEQGLAAPADT 386

  Fly  1141 -VSKVERI----NVFERKSGRVITGHMAPSAHQFR----KWLQENPSFEVLPSGTVQSADAEKRL 1196
             .|..|.:    :..:.::.|..:|   |...|.|    |.|::.|.......||.:|:|...
Human   387 CASSREPLGGLSSSLDTEASRACSG---PFMEQRRSKGTKNLKKGPVPCAQDRGTDRSSDNSH-- 446

  Fly  1197 LKGAPEAATSTSEPAVLGVAK----KPPEGP---------------AKLSHPQNTTVQASHQL-- 1240
             :..||      ||:..|..:    |.|.|.               ..:||.     ||..||
Human   447 -QDRPE------EPSPGGCPRLEEVKIPHGVKLVCYLGSGPVIQLLGAISHG-----QAGGQLPP 499

  Fly  1241 ---------GISSVRPLAKKDKEKTTPTVQA--------PTPNRIAAGKP--------------- 1273
                     .:||..| |::.:.|..|.||.        |:|:...||.|
Human   500 KLEVLEDLMEVSSPSP-AQRLRRKKRPMVQGPAGCQVFQPSPSGGTAGDPGGLSDPFYPPRSGSL 563

  Fly  1274 --------------------------EP------------VRIGIR----RSLREQLLARIKEAQ 1296
                                      :|            :.||:|    ||::|.|..|::|..
Human   564 ALGDPSSDPACSQSGPMEAEEDSLPEQPEDSAQLQQEKPSLYIGVRGTVVRSMQEVLWTRLRELP 628

  Fly  1297 AAEENSGQPTTQWPTVLE--VDQFVKNVELEMFNSFGRDVGAKYKAKYRSLMFNIKDRKNRTLFE 1359
            .            |.:.|  |:.....:|..::: ..:....:||.|||||:||::|.:|..||.
Human   629 D------------PVLSEEVVEGIAAGIEAALWD-LTQGTNGRYKTKYRSLLFNLRDPRNLDLFL 680

  Fly  1360 KICAKQVEPRQLVRMTPEQLASQELAKWREEENRHQLDMIKKSELDLLACAQNYVVKTHKGEEVI 1424
            |:....|.|..||||:..|||.||||:||::|.:..|::|::.:.:  .|.......|||||..|
Human   681 KVVHGDVTPYDLVRMSSMQLAPQELARWRDQEEKRGLNIIEQQQKE--PCRLPASKMTHKGEVEI 743

  Fly  1425 ATKVDVTLPEENVSEASSMADTKQTSL--VSEPSTSTLERSTSREKAGSSKEKRHKSHKHH---- 1483
            ...:|.||..|::.......|....:|  .||.:|.                    .|.||
Human   744 QRDMDQTLTLEDLVGPQMFMDCSPQALPIASEDTTG--------------------QHDHHFLDP 788

  Fly  1484 --HRKRSRSRSNSRGRSVDKRHRRQHNEGGEQPGSGEREHRSREKQSRERDEIVPSPLPKKRDEN 1546
              |..:....||                  |..||.|.....       .|.|....|
Human   789 NCHICKDWEPSN------------------ELLGSFEAAKSC-------GDNIFQKAL------- 821

  Fly  1547 DQSPVPKKTAEKKTEASAYNLVDQILESEKTVEQAANLGKPKPSPKPLPTLPSSLKAPEPMDNYS 1611
            .|:|:|.....|..|.|.....|::..|        .|..|....|.||.||.
Human   822 SQTPMPAPEMPKTRELSPTEPQDRVPPS--------GLHVPAAPTKALPCLPP------------ 866

  Fly  1612 RYLHGLTTSSLWSGTLKMIDLADFEIVMYPVQGNCHQLGNLMPSQMDVIGRITRVNVWEYIKKLK 1676
                       |.|.|.|..:..|......|.|:..:|...:|:.:...|.|....||:.:..:.
Human   867 -----------WEGVLDMFSIKRFRARAQLVSGHSCRLVQALPTVIRSAGCIPSNIVWDLLASIC 920

  Fly  1677 KSPTKEVVIVNIFPASPSETYKFDLFFEYLDSRQRLGVLGVDSDQIRDFYIFPLGSGDKLPPALQ 1741
            .:..|:|.:|.:.|....:|....|.:.||:.|||.|:..|:.   ....:.||.:...||..|:
Human   921 PAKAKDVCVVRLCPHGARDTQNCRLLYSYLNDRQRHGLASVEH---MGMVLLPLPAFQPLPTRLR 982

  Fly  1742 T-------AEPV-PFYE---EAQRPNTLLGIIVRCLSKRPADAVPSTPSVPTPVPALSSKVAKRS 1795
            .       |.|| |...   |....:.||.:::      |.:.:|.|
Human   983 PLGGPGLWALPVSPLLSPGLEVTHSSLLLAVLL------PKEGLPDT------------------ 1023

  Fly  1796 RSSISYPAQSSP-----KRKISTHSTSSK-----DDEFDIDAIIKAPIAKLQKTAPKVVPQPSVP 1850
                   |.|||     ::.:|.:|...|     ||.                       :|:||
Human  1024 -------AGSSPWLGKVQKMVSFNSKVEKRYYQPDDR-----------------------RPNVP 1058

  Fly  1851 NDADEPYSPGGSDDE------LVP---SAPQRP 1874
            .....|  |||:..:      :.|   ||.|||
Human  1059 LKGTPP--PGGAWQQSQGRGSIAPRGISAWQRP 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pps	NP_001247075.1	TNG2	<827..965	CDD:227367	31/137 (23%)
		PHD_PHF3_like	914..963	CDD:277027	9/48 (19%)
		BRK	1142..1186	CDD:197800	10/51 (20%)
		TFIIS_M	1274..1396	CDD:284835	44/139 (32%)
		SPOC	1623..1729	CDD:285043	26/105 (25%)
SPOCD1	NP_653170.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..74		20/98 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..216		10/55 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..325		20/102 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..462		28/125 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..601		14/90 (16%)
		TFIIS_M	608..717	CDD:284835	41/121 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	823..850		8/34 (24%)
		SPOC	867..965	CDD:285043	26/100 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1046..1140		15/69 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1176..1216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151805
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1634
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7155
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41808
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11477
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.840