Protein Alignment pps and BYE1

DIOPT Version :10

• Sequence 1: NP_001247075.1
• Gene: pps / 41524
• FlyBaseID: FBgn0082831
• Length: 2018
• Species: Drosophila melanogaster
• Sequence 2: NP_012921.3
• Gene: BYE1 / 853865
• SGDID: S000001488
• Length: 594
• Species: Saccharomyces cerevisiae
• Alignment Length: 936
• Identity: 153/936 - (16%)
• Similarity: 271/936 - (28%)
• Gaps: 426/936 - (45%)

  Fly   852 LNTSSLSNDSQ----------PGSGPKRPNPREPSMARRSTAPRRSKKLDASQNNDPDASE---S 903
            :.|||.||..|          ....||:...::    :..:|..::||.|:||....|...   .
Yeast     3 VRTSSRSNKGQNKYIEYLLQEETEAPKKKRTKK----KVDSAIEKNKKSDSSQEPRKDTENVRTD 63

  Fly   904 QEDDDDPNKLWCICRQPHNN--------RFMICCDLCEDWFHGTCVGVTKAMGTDMENKGIDWKC 960
            :.|:.|...:.|:|...:.|        ..|:.||.|:.|.|..|
Yeast    64 EVDEADEGYVRCLCGANNENYDAAEYSHGDMVQCDGCDTWQHIKC-------------------- 108

  Fly   961 PKCVKRQEERSQPRITDMLVTRPTTQPEQRPSETKVLTTTAEIVQVAAPSAPRRTLPVVLTVASS 1025
                          :||
Yeast   109 --------------MTD------------------------------------------------ 111

  Fly  1026 PMRIPMAKPAKKFPTGAISHQQQQQLNFIRLGPSPGKRISETLCVVCKRPASTSSVYCGEECIRK 1090
                                               ||...:.|.      :..|..|| |.|
Yeast   112 -----------------------------------GKDTIDGLM------SEDSKYYC-ELC--- 131

  Fly  1091 YAQSAIQAHAATKGPLPQNAGAQSLLNNSFDAKKNKKKDLFEDVLRQADTVSKVERINVFERKSG 1155
              ..::.||                |..|.:|:.::.:|..:||.:.
Yeast   132 --DPSLYAH----------------LETSKEAEVSEDEDYHDDVYKP------------------ 160

  Fly  1156 RVITGHMAPSAHQFRKWLQENPSFEVLPSGTVQSADAEKRLLKGAPEAATSTSEPAVLGVAKKPP 1220
              :..|....|..|..  :|:|                 |..|.:|::|....   :.....|..
Yeast   161 --VNDHDDNDADVFLD--EESP-----------------RKRKRSPDSAKGIH---IKSKQVKKS 201

  Fly  1221 EGPAKLSHPQNTTVQASHQLGISSVRPLAKKDKEKTTPTVQAPTPNRIAAGKPEPVRIGIRRS-- 1283
            .|..|    :|.::.|            ||.|    |...:.||.....:.|...:|....:.
Yeast   202 NGSKK----RNKSIDA------------AKSD----TAENEMPTRKDFESEKEHKLRYNAEKMFS 246

  Fly  1284 --LREQLLARIKEAQAAEENSGQPTTQWPTVLEVDQ-FVKNVELEMFNS-----FGRDVGAKYKA 1340
              ..:.::....||:..|...|:      .|:.:.| |..|:|.|::.:     || .:...|..
Yeast   247 TLFSKFIVPETIEAKLYELPDGK------DVISISQEFAHNLEEELYKACLNVEFG-TLDKIYTE 304

  Fly  1341 KYRSLMFNIKDRKNRTLFEKICAKQVEPRQLVRMTPEQLASQELAKWREEENRHQLDMIKKSELD 1405
            |.|||..|:||:||..|...:...::...:||.|...:||:.:|.:::|:.::..|
Yeast   305 KVRSLYSNLKDKKNLELKAHVVEGKLPLNKLVNMNASELANPDLQEFKEKRDKIIL--------- 360

  Fly  1406 LLACAQNYV---------VKTHKGEEVIATKVDVTLPEENVSEASSMADTKQTSLVSEPSTSTLE 1461
                 :|::         ||||||:|:|.   |:..|:|::             |.|:.|.
Yeast   361 -----ENFIVEVPDKPMYVKTHKGDELIE---DIAEPQEDI-------------LYSKDSI---- 400

  Fly  1462 RSTSREKAGSSKEKRHKSHKHHHRKRSRSRSNSRGRSVDKRHRRQHNEGGEQPGSGEREHRSREK 1526
                                                       |.||
Yeast   401 -------------------------------------------RLHN------------------ 404

  Fly  1527 QSRERDEIVPSPLPKKRDENDQSPVPKKTAEKKTEASAYNLVDQILESEKTVEQAANLGKPKPSP 1591
                                                     :|.|...:..:||...:.| :|||
Yeast   405 -----------------------------------------IDSIDSDKSKIEQTHAISK-EPSP 427

  Fly  1592 KPL---PTLPSSLKAPEPMDNYSRYLHGLTTSSLWSGTLKMIDLADFEIVMYPVQGNCHQLGNLM 1653
            ..:   .:|..:...|.....::.||:.:..|......:....:.|
Yeast   428 STIINEESLNCAFLYPGLGLEFTGYLNYIGASQKLRRDIFKEAIGD------------------- 473

  Fly  1654 PSQMDVIGRITRVNVWEYIKKLKKSPTKEVVIVNIFPASPSETYKFDLFFEYLDSRQRLG-VLGV 1717
             .::.|.||:.......|:|::  |.::.:::..:||::.||:.  ..|.:.:||.:..| :.|:
Yeast   474 -GKLYVEGRLPTTTAAPYLKEI--SCSRAILVYQLFPSNDSESK--TTFADVVDSLENKGRIAGI 533

  Fly  1718 --DSDQIRDFYIFPLGSGDKLPPALQ 1741
              .:...:||||.| ..|.::|..|:
Yeast   534 KPKTRYEKDFYIVP-SKGGEIPEILK 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pps	NP_001247075.1	DUF3295	641..>914	CDD:403030	17/74 (23%)
		TNG2	<827..965	CDD:227367	27/133 (20%)
		PHD_PHF3_like	914..963	CDD:277027	10/56 (18%)
		BRK	1141..1184	CDD:462196	5/42 (12%)
		TFIIS_M	1274..1399	CDD:462184	32/134 (24%)
		SPOC_PPS-like	1622..1764	CDD:439214	24/123 (20%)
BYE1	NP_012921.3	PHD_Bye1p_SIZ1_like	74..131	CDD:277045	19/180 (11%)
		TFS2M	235..354	CDD:128786	30/125 (24%)
		SPOC_Bye1p-like	436..589	CDD:439205	29/148 (20%)