DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pps and BYE1

DIOPT Version :9

Sequence 1:	NP_001247075.1	Gene:	pps / 41524	FlyBaseID:	FBgn0082831	Length:	2018	Species:	Drosophila melanogaster
Sequence 2:	NP_012921.3	Gene:	BYE1 / 853865	SGDID:	S000001488	Length:	594	Species:	Saccharomyces cerevisiae

Alignment Length:	936	Identity:	153/936 - (16%)
Similarity:	271/936 - (28%)	Gaps:	426/936 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   852 LNTSSLSNDSQ----------PGSGPKRPNPREPSMARRSTAPRRSKKLDASQNNDPDASE---S 903
            :.|||.||..|          ....||:...::    :..:|..::||.|:||....|...   .
Yeast     3 VRTSSRSNKGQNKYIEYLLQEETEAPKKKRTKK----KVDSAIEKNKKSDSSQEPRKDTENVRTD 63

  Fly   904 QEDDDDPNKLWCICRQPHNN--------RFMICCDLCEDWFHGTCVGVTKAMGTDMENKGIDWKC 960
            :.|:.|...:.|:|...:.|        ..|:.||.|:.|.|..|
Yeast    64 EVDEADEGYVRCLCGANNENYDAAEYSHGDMVQCDGCDTWQHIKC-------------------- 108

  Fly   961 PKCVKRQEERSQPRITDMLVTRPTTQPEQRPSETKVLTTTAEIVQVAAPSAPRRTLPVVLTVASS 1025
                          :||
Yeast   109 --------------MTD------------------------------------------------ 111

  Fly  1026 PMRIPMAKPAKKFPTGAISHQQQQQLNFIRLGPSPGKRISETLCVVCKRPASTSSVYCGEECIRK 1090
                                               ||...:.|.      :..|..|| |.|
Yeast   112 -----------------------------------GKDTIDGLM------SEDSKYYC-ELC--- 131

  Fly  1091 YAQSAIQAHAATKGPLPQNAGAQSLLNNSFDAKKNKKKDLFEDVLRQADTVSKVERINVFERKSG 1155
              ..::.||                |..|.:|:.::.:|..:||.:.
Yeast   132 --DPSLYAH----------------LETSKEAEVSEDEDYHDDVYKP------------------ 160

  Fly  1156 RVITGHMAPSAHQFRKWLQENPSFEVLPSGTVQSADAEKRLLKGAPEAATSTSEPAVLGVAKKPP 1220
              :..|....|..|..  :|:|                 |..|.:|::|....   :.....|..
Yeast   161 --VNDHDDNDADVFLD--EESP-----------------RKRKRSPDSAKGIH---IKSKQVKKS 201

  Fly  1221 EGPAKLSHPQNTTVQASHQLGISSVRPLAKKDKEKTTPTVQAPTPNRIAAGKPEPVRIGIRRS-- 1283
            .|..|    :|.::.|            ||.|    |...:.||.....:.|...:|....:.
Yeast   202 NGSKK----RNKSIDA------------AKSD----TAENEMPTRKDFESEKEHKLRYNAEKMFS 246

  Fly  1284 --LREQLLARIKEAQAAEENSGQPTTQWPTVLEVDQ-FVKNVELEMFNS-----FGRDVGAKYKA 1340
              ..:.::....||:..|...|:      .|:.:.| |..|:|.|::.:     || .:...|..
Yeast   247 TLFSKFIVPETIEAKLYELPDGK------DVISISQEFAHNLEEELYKACLNVEFG-TLDKIYTE 304

  Fly  1341 KYRSLMFNIKDRKNRTLFEKICAKQVEPRQLVRMTPEQLASQELAKWREEENRHQLDMIKKSELD 1405
            |.|||..|:||:||..|...:...::...:||.|...:||:.:|.:::|:.::..|
Yeast   305 KVRSLYSNLKDKKNLELKAHVVEGKLPLNKLVNMNASELANPDLQEFKEKRDKIIL--------- 360

  Fly  1406 LLACAQNYV---------VKTHKGEEVIATKVDVTLPEENVSEASSMADTKQTSLVSEPSTSTLE 1461
                 :|::         ||||||:|:|.   |:..|:|::             |.|:.|.
Yeast   361 -----ENFIVEVPDKPMYVKTHKGDELIE---DIAEPQEDI-------------LYSKDSI---- 400

  Fly  1462 RSTSREKAGSSKEKRHKSHKHHHRKRSRSRSNSRGRSVDKRHRRQHNEGGEQPGSGEREHRSREK 1526
                                                       |.||
Yeast   401 -------------------------------------------RLHN------------------ 404

  Fly  1527 QSRERDEIVPSPLPKKRDENDQSPVPKKTAEKKTEASAYNLVDQILESEKTVEQAANLGKPKPSP 1591
                                                     :|.|...:..:||...:.| :|||
Yeast   405 -----------------------------------------IDSIDSDKSKIEQTHAISK-EPSP 427

  Fly  1592 KPL---PTLPSSLKAPEPMDNYSRYLHGLTTSSLWSGTLKMIDLADFEIVMYPVQGNCHQLGNLM 1653
            ..:   .:|..:...|.....::.||:.:..|......:....:.|
Yeast   428 STIINEESLNCAFLYPGLGLEFTGYLNYIGASQKLRRDIFKEAIGD------------------- 473

  Fly  1654 PSQMDVIGRITRVNVWEYIKKLKKSPTKEVVIVNIFPASPSETYKFDLFFEYLDSRQRLG-VLGV 1717
             .::.|.||:.......|:|::  |.::.:::..:||::.||:.  ..|.:.:||.:..| :.|:
Yeast   474 -GKLYVEGRLPTTTAAPYLKEI--SCSRAILVYQLFPSNDSESK--TTFADVVDSLENKGRIAGI 533

  Fly  1718 --DSDQIRDFYIFPLGSGDKLPPALQ 1741
              .:...:||||.| ..|.::|..|:
Yeast   534 KPKTRYEKDFYIVP-SKGGEIPEILK 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pps	NP_001247075.1	TNG2	<827..965	CDD:227367	27/133 (20%)
		PHD_PHF3_like	914..963	CDD:277027	10/56 (18%)
		BRK	1142..1186	CDD:197800	5/43 (12%)
		TFIIS_M	1274..1396	CDD:284835	31/131 (24%)
		SPOC	1623..1729	CDD:285043	20/108 (19%)
BYE1	NP_012921.3	PHD_Bye1p_SIZ1_like	74..131	CDD:277045	19/180 (11%)
		TFS2M	235..354	CDD:128786	30/125 (24%)
		SPOC	434..589	CDD:400205	29/150 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1634
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11477
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030