DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pps and SET4

DIOPT Version :9

Sequence 1:	NP_001247075.1	Gene:	pps / 41524	FlyBaseID:	FBgn0082831	Length:	2018	Species:	Drosophila melanogaster
Sequence 2:	NP_012430.1	Gene:	SET4 / 853339	SGDID:	S000003641	Length:	560	Species:	Saccharomyces cerevisiae

Alignment Length:	560	Identity:	102/560 - (18%)
Similarity:	170/560 - (30%)	Gaps:	231/560 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   808 EAPTTRAKRRAQ-FPSAPGMAATSSSDAGNLSFGESSLDASINQPLNTSSLSND----------- 860
            |:.::|..|:.: :.:...:.:.|||.:.|.|.   |.|...:.||:.||.:::
Yeast     5 ESLSSRHIRQGRTYTTTDKVISRSSSYSSNSSM---SKDYGDHTPLSVSSAASETLPSPQYMPIR 66

  Fly   861 ---SQPGSGP----------------------------KRPNPREPSMARRSTAPRRSKKLDASQ 894
               :.|.:||                            ||......::|..:|.|...||    |
Yeast    67 TFNTMPTAGPTPLHLFQNDRGIFNHHSSSGSSKTASTNKRGIAAAVALATAATIPFPLKK----Q 127

  Fly   895 NNDPDA------SESQED---------DDDPNKLWCIC-RQPHNNRFMICCDLCEDWFHGTCVGV 943
            |.|.::      :||.::         :|:..|..||| .....:...|.|:.|:.|.|..|...
Yeast   128 NQDDNSKVSVTHNESSKENKITPSMRAEDNKPKNGCICGSSDSKDELFIQCNKCKTWQHKLCYAF 192

  Fly   944 TKAMGTDMENKGIDWKCPKCVKRQEERSQPRITDMLVTRPTTQPEQRPSETKVLTTTAEIVQVAA 1008
            .|   :|...:  |:.|.:|                           .|:|||     ::.||..
Yeast   193 KK---SDPIKR--DFVCKRC---------------------------DSDTKV-----QVNQVKP 220

  Fly  1009 PSAPRRT--------LPVVLTVASSPMRIPMAKPAKKFPTGAISHQQQQQLNFIRLGPSPGKRIS 1065
            ...||:.        ..:|.|.||:                  ::|.||.:|.|.  ..|.||
Yeast   221 MIFPRKMGDERLFQFSSIVTTSASN------------------TNQHQQSVNNIE--EQPKKR-- 263

  Fly  1066 ETLCVVCKRPASTSSVYCGEECIRKYAQSAIQAHAATKGPLPQNAGA--QSLLNNSFDAKKNKKK 1128
                                           |.|..  .|..:|:.:  :.|.........:..|
Yeast   264 -------------------------------QLHYT--APTTENSNSIRKKLRQEKLVVSSHFLK 295

  Fly  1129 DLFEDVLRQADTVSKVERINVFERKSGRVITGHMAPSAHQFRKWLQENPSFEVLPSGTVQSADAE 1193
            .|..:|....||..|...|:.::.|..::...:     |....|        |:.|....|..|:
Yeast   296 PLLNEVSSSNDTEFKAITISEYKDKYVKMFIDN-----HYDDDW--------VVCSNWESSRSAD 347

  Fly  1194 KRLLKGAPE------AATS------------------------TSEPAVLGVAKKPPEGPAKLSH 1228
            ..:.|.:.|      ||.|                        .::..::|..|     |..|.|
Yeast   348 IEVRKSSNERDFGVFAADSCVKGELIQEYLGKIDFQKNYQTDPNNDYRLMGTTK-----PKVLFH 407

  Fly  1229 PQNTTVQASHQLG---------------ISSVRPLAKKDK 1253
            |.......|.:.|               :.:||||.:|.:
Yeast   408 PHWPLYIDSRETGGLTRYIRRSCEPNVELVTVRPLDEKPR 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pps	NP_001247075.1	TNG2	<827..965	CDD:227367	42/195 (22%)
		PHD_PHF3_like	914..963	CDD:277027	13/49 (27%)
		BRK	1142..1186	CDD:197800	7/43 (16%)
		TFIIS_M	1274..1396	CDD:284835
		SPOC	1623..1729	CDD:285043
SET4	NP_012430.1	SET	16..526	CDD:225491	99/549 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030