DRSC/TRiP Functional Genomics Resources

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Protein Alignment pps and KMT2D

DIOPT Version :9

Sequence 1:NP_001247075.1 Gene:pps / 41524 FlyBaseID:FBgn0082831 Length:2018 Species:Drosophila melanogaster
Sequence 2:XP_011537072.1 Gene:KMT2D / 8085 HGNCID:7133 Length:5556 Species:Homo sapiens


Alignment Length:2151 Identity:420/2151 - (19%)
Similarity:636/2151 - (29%) Gaps:793/2151 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   206 TPFTSPEQLKNHKRDEKMAMEMQAQSRKIIMQAPGSVKLINAKKRVQAIPLS--------PVQVK 262
            :|.:.|.:      |..|::.::        ::|    |:...:..|..|.|        |.:..
Human   705 SPASPPPE------DSLMSLPLE--------ESP----LLPLPEEPQLCPRSEGPHLSPRPEEPH 751

  Fly   263 VQRLPVKPHQVQQAAQLQPKVQLIRKPIHSPLPRQK-----PEIIANNSVNARLRPTRAPVKVIA 322
            :...|.:||       |.|:.:   :|..||.|.:.     ||       ...|.|......:..
Human   752 LSPRPEEPH-------LSPQAE---EPHLSPQPEEPCLCAVPE-------EPHLSPQAEGPHLSP 799

  Fly   323 PPVQEYIE-DDDDAQSSDSAEEENADKAYDSEEMSEESDEFQESDNDRDSDMDFDMRHSNRRNPN 386
            .|.:.::. ..::...|...||.......:...:|.:|:|...|....:|.:..::     ..|.
Human   800 QPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPEL-----EKPP 859

  Fly   387 KRKRVRKVVR---QTPSKPMKPLPPPPTTPQHFPELKKRKEVLEPKAPQIGQIIQMPATKSVPAV 448
            ...|..|...   |.|:....||.|||..|...|.|.      ||...:.|:    |....:|..
Human   860 LSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLG------EPALSEPGE----PPLSPLPEE 914

  Fly   449 FALG-RGLPSTSFLKIRPTHQSLPVKRPPLPTTPANSNV---RRMPAVQ-LGRI----------- 497
            ..|. .|.||.|           |...||.|..|..|.:   ...||:. ||.:           
Human   915 LPLSPSGEPSLS-----------PQLMPPDPLPPPLSPIITAAAPPALSPLGELEYPFGAKGDSD 968

  Fly   498 ---------------------VNSPQEVKEIIINKNMASPKGVFTNLNTLLGEDNNAATKSSPV- 540
                                 ...|:.|..:|:..:..||.|                 .:||: 
Human   969 PESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPVG-----------------PASPIL 1016

  Fly   541 ---------PLRHRAVMSPSTPRSSYNQQMSPIVVPVPAQAHTPSKGFMPIG-----VDTAQSHK 591
                     ||...:::..::|.|..:....|:.||.|         ..|||     .|.|:.|:
Human  1017 MEPLPPQCSPLLQHSLVPQNSPPSQCSPPALPLSVPSP---------LSPIGKVVGVSDEAELHE 1072

  Fly   592 LPAQIVIETHQSSSELAAENDKQLDLINSIVQDELLKSTLVEQPVVNADEDIPKLVKMLESTAAD 656
            :                 |.:|                  |.:|...|.|  |.....|.|...|
Human  1073 M-----------------ETEK------------------VSEPECPALE--PSATSPLPSPMGD 1100

  Fly   657 LDPPPVSLPTNIFPAP---EMQGVGNAAAADPNNIMDTANEDEITADFLQHVVGLIEEDKQFEAE 718
            |..|..|      |||   :..|:|.          |||..|.|.|.      |...|..|....
Human  1101 LSCPAPS------PAPALDDFSGLGE----------DTAPLDGIDAP------GSQPEPGQTPGS 1143

  Fly   719 VVKQVLASTEPGTLDAIVSMPTSIEPVDVPQVQAHTNLLPNASLTEPAQSMTSLPIACSTPSRSV 783
            :..::..|  |..||     |..:.||...:|      .|....|....|    |.......|:.
Human  1144 LASELKGS--PVLLD-----PEELAPVTPMEV------YPECKQTAGQGS----PCEEQEEPRAP 1191

  Fly   784 AASTPPTSAK--VVRGYGRVIYLPPIEAPTTRAKRRAQFP-SAPGMAATSSSDAGNLS--FGESS 843
            .|.||||..|  :|.....:          ::....|.|| |.|.:.:......|:||  .|.|:
Human  1192 VAPTPPTLIKSDIVNEISNL----------SQGDASASFPGSEPLLGSPDPEGGGSLSMELGVST 1246

  Fly   844 LDASINQPLNTSSLSNDSQPG-------------SGPKRPNPREPSMARRSTAPRRSK------- 888
             |.|..:...:..|..||.|.             ||.|    .|....||.::|.||:       
Human  1247 -DVSPARDEGSLRLCTDSLPETDDSLLCDAGTAISGGK----AEGEKGRRRSSPARSRIKQGRSS 1306

  Fly   889 -----------------------KLDASQ---------NNDPDASESQEDDDDPNK--------- 912
                                   |..||.         ::.|...|.:||||....         
Human  1307 SFPGRRRPRGGAHGGRGRGRARLKSTASSIETLVVADIDSSPSKEEEEEDDDTMQNTVVLFSNTD 1371

  Fly   913 -------LWCIC------RQPHNNRFMICCDLCEDWFHGTCVG--VTKAMGTDMENKGIDWKCPK 962
                   :..:|      .:.|    ::.|..|...:|..||.  :||.|..    ||  |:|.:
Human  1372 KFVLMQDMCVVCGSFGRGAEGH----LLACSQCSQCYHPYCVNSKITKVMLL----KG--WRCVE 1426

  Fly   963 CVKRQEERSQPRITDMLVTRPTTQPEQRPSETKVLTTTAEIVQVAAPSAPRRTL----------- 1016
            |:                                   ..|:...|  |.|.|.|           
Human  1427 CI-----------------------------------VCEVCGQA--SDPSRLLLCDDCDISYHT 1454

  Fly  1017 ----PVVLTVASSPMRIPMAKPAKKFPTGAISHQQQQQLNFIRLGPSPGKRISETLCVVCKRPAS 1077
                |.:|||.....:........:....:.....:.|.::...||.    .|...|.:|..|  
Human  1455 YCLDPPLLTVPKGGWKCKWCVSCMQCGAASPGFHCEWQNSYTHCGPC----ASLVTCPICHAP-- 1513

  Fly  1078 TSSVYCGEECIRKYAQSAIQAHAATKGPLPQNAGAQSLLNNSFDAKKNKKKDLFEDVLRQADTVS 1142
                |..|:.:       ||.....:.   .:||.:||...  |..:....:.|:.|..|...|.
Human  1514 ----YVEEDLL-------IQCRHCERW---MHAGCESLFTE--DDVEQAADEGFDCVSCQPYVVK 1562

  Fly  1143 KVERINVFERKSGRVITGHMAPSAHQFR---KWLQENPSFEVLPSGTVQSAD--AEKRLLKGAP- 1201
            .|..:...|....:|    ..|....||   .||.|. ...:|.:.|:....  .::|...|.| 
Human  1563 PVAPVAPPELVPMKV----KEPEPQYFRFEGVWLTET-GMALLRNLTMSPLHKRRQRRGRLGLPG 1622

  Fly  1202 EAATSTSEPA-VLGVAKKPP---------EGPAKLSHPQNTTVQASHQLGISSVRPLAKKDKEKT 1256
            ||....|||: .||...|..         :|...:.|     ::...:|. ..|.|..:..||:|
Human  1623 EAGLEGSEPSDALGPDDKKDGDLDTDELLKGEGGVEH-----MECEIKLE-GPVSPDVEPGKEET 1681

  Fly  1257 TPTVQAPTPNRIAAGKPEPVRIGIRRSLREQLLA--RIKEAQAAE----ENSGQPTTQWPTVLEV 1315
            ..:.:.         |.:|.|.||...:..|..:  |.|:..||:    ...||| .:..||:..
Human  1682 EESKKR---------KRKPYRPGIGGFMVRQRKSHTRTKKGPAAQAEVLSGDGQP-DEGETVIPA 1736

  Fly  1316 DQFVKNVELEMFNSFGRDVGAKYKAKYRSLMFNIKDRKNRTLFEKICAKQVEPRQLVRMTPEQLA 1380
            |                                                         :..|...
Human  1737 D---------------------------------------------------------LPAEGAV 1744

  Fly  1381 SQELAKWREEENRHQLDMIKKSELDLLACAQNYVVKTHKGEEVIATKVDVTLPEENVSEASSMAD 1445
            .|.||: .:|:.:.|....|||:|:.:..|  |:.:...|:|::                    |
Human  1745 EQSLAE-GDEKKKQQRRGRKKSKLEDMFPA--YLQEAFFGKELL--------------------D 1786

  Fly  1446 TKQTSL----VSEPSTSTLERSTSREKAGSSKEKRHKSHKHHHRKRSRSRSNSRGRSVDKRHRRQ 1506
            ..:.:|    |..||.. |....::...||.:::...|.|                         
Human  1787 LSRKALFAVGVGRPSFG-LGTPKAKGDGGSERKELPTSQK------------------------- 1825

  Fly  1507 HNEGGEQPGSGEREHRSREKQS----RERDEIVPSPLPKKRDE----------NDQSPVPKKTAE 1557
               |.:.|...:.|.|..|.::    .|...:..||:|...::          :|...:..:...
Human  1826 ---GDDGPDIADEESRGLEGKADTPGPEDGGVKASPVPSDPEKPGTPGEGMLSSDLDRISTEELP 1887

  Fly  1558 KKTEASAYNLVDQILESEKTVEQAANLGKP----------KP---SPKPLPTLPSSLKAPEPMDN 1609
            |........|...:|.||:  ||....|.|          :|   ...||..||||    .|||:
Human  1888 KMESKDLQQLFKDVLGSER--EQHLGCGTPGLEGSRTPLQRPFLQGGLPLGNLPSS----SPMDS 1946

  Fly  1610 Y-----SRYL----------------------HGLTTSSL----------------------WSG 1625
            |     |.:|                      .|.||.|.                      |..
Human  1947 YPGLCQSPFLDSRERGGFFSPEPGEPDSPWTGSGGTTPSTPTTPTTEGEGDGLSYNQRSLQRWEK 2011

  Fly  1626 TLKMIDLADFEIVMYPVQGNCHQLGNLMPSQMDVIGRITRV-NVWEYIKKLKKSPTKEVV----- 1684
            ..::..|:....|:|   .|.: ..||.....|...|..:: .:|..:....|:|..:..     
Human  2012 DEELGQLSTISPVLY---ANIN-FPNLKQDYPDWSSRCKQIMKLWRKVPAADKAPYLQKAKDNRA 2072

  Fly  1685 ---IVNIFPASPSETYKFDLFFEYLDSRQRLGVLGVDSDQIRDFYIFP-----LGSGDKLPPALQ 1741
               |..:...:.|:          ::.:.::|.:...:|:.......|     |||.   |||  
Human  2073 AHRINKVQKQAESQ----------INKQTKVGDIARKTDRPALHLRIPPQPGALGSP---PPA-- 2122

  Fly  1742 TAEPVPFYEEAQRPNTLLGIIVRC--LSKRPADAVPS-----------TPSVPTPVPA------- 1786
             |.|..|...   |.|..|:....  ..|.||.:||.           .|.||..||:       
Human  2123 -AAPTIFIGS---PTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPPQVPAQVPSQDPFGLA 2183

  Fly  1787 ----LSSKVAKRSRSSISYPAQSS-----PKRKISTHSTSSKDDEFDIDAIIKAPIAKLQKTAPK 1842
                |..:......:...||:.:.     |....|:...:.:..||              .|.|.
Human  2184 PAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEF--------------HTTPP 2234

  Fly  1843 VVP--QPSVPNDADEPYSP--------------GGSDDELVPSAPQRPNDLERQVNEINKQIAAQ 1891
            ..|  |||.|:...:|..|              ||...|.:.|.|  |....|:..|:.|     
Human  2235 GTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPLLSPP--PFGESRKALEVKK----- 2292

  Fly  1892 QMEIAGLLKVEPTGSASSSNVLAAISIPANLSKILASIKDKTNLPSSADD-GDEEYNPEDDITA- 1954
                      |..|::|.|..      |.||..:        :.|||... |..|....|...| 
Human  2293 ----------EELGASSPSYG------PPNLGFV--------DSPSSGTHLGGLELKTPDVFKAP 2333

  Fly  1955 -TSSFASKKPRSKG---RLAHLSEAELLSMVPDNLAGVIPRSSRTRHQLAQSPLTPTPLPPPP-- 2013
             |...:..:|:|.|   |......|:.|:..|.:...:....|.| ...||.||||.|.||||  
Human  2334 LTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYT-DPYAQPPLTPRPQPPPPES 2397

  Fly  2014 ----PP 2015
                ||
Human  2398 CCALPP 2403

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppsNP_001247075.1 TNG2 <827..965 CDD:227367 44/215 (20%)
PHD_PHF3_like 914..963 CDD:277027 14/56 (25%)
BRK 1142..1186 CDD:197800 10/46 (22%)
TFIIS_M 1274..1396 CDD:284835 20/127 (16%)
SPOC 1623..1729 CDD:285043 16/114 (14%)
KMT2DXP_011537072.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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