back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pps and NSD2

DIOPT Version :9

Sequence 1:	NP_001247075.1	Gene:	pps / 41524	FlyBaseID:	FBgn0082831	Length:	2018	Species:	Drosophila melanogaster
Sequence 2:	NP_001035889.1	Gene:	NSD2 / 7468	HGNCID:	12766	Length:	1365	Species:	Homo sapiens

Alignment Length:	1591	Identity:	285/1591 - (17%)
Similarity:	466/1591 - (29%)	Gaps:	621/1591 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 MRHSNRRNPNKRKRVRKVVRQTPSKPMKPLP-----PPPTTPQHFPELKKRKEVLEPKAPQIGQI 436
            |..|.:::|...:.|.|.::      ||..|     ....||.  .|:.:...|...|| |:...
Human     1 MEFSIKQSPLSVQSVVKCIK------MKQAPEILGSANGKTPS--CEVNRECSVFLSKA-QLSSS 56

  Fly   437 IQ---------------MPATKSVPAVFALGRGLPSTSFLKIRPTHQSLPVKRPPLPTTPANSNV 486
            :|               :||.|.......:..|.|.....|:|...|.:.....|..|||
Human    57 LQEGVMQKFNGHDALPFIPADKLKDLTSRVFNGEPGAHDAKLRFESQEMKGIGTPPNTTP----- 116

  Fly   487 RRMPAVQLGRIVNSPQEVKEIIINKNMASPKGVFTNLNTLLGEDNNAATKSSPVPLRHRAVMSPS 551
                      |.|...|:| :.|.|...:.|.:|.  :::.|:.
Human   117 ----------IKNGSPEIK-LKITKTYMNGKPLFE--SSICGDS--------------------- 147

  Fly   552 TPRSSYNQQMSPIVVPVPAQAHTPSKGFMPIGVDTAQSHKLPAQIVIETHQSSSELAAENDKQLD 616
                                           ..|.:||.        |..|.....|..|.|:
Human   148 -------------------------------AADVSQSE--------ENGQKPENKARRNRKR-- 171

  Fly   617 LINSIVQDELLKSTLVEQPVVN-----ADEDIPKLVKMLESTAADLD------------------ 658
               ||..|.||:..|||..:|:     :|:.||...:...:|..|.|
Human   172 ---SIKYDSLLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGY 233

  Fly   659 ---PPPVSLPTNIFPAPEMQGVGNAAAADPNNIMDTANEDEITADFLQHVVGLIEEDKQFE---- 716
               |..||....:....:::|...:|..........|.|   .|...:..:...|.:.|||
Human   234 PWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPE---RAWIFEKSLVAFEGEGQFEKLCQ 295

  Fly   717 ---------AEVVK-------QVLASTEPGTLDAIVSMPTSIEPVDV--------------PQVQ 751
                     ||.:|       ::.|..|.|.:.|..:...|:|....              |||.
Human   296 ESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNPQVA 360

  Fly   752 AHTNLLPNASLTEPAQSMTSLPIACSTPSRSVAASTPPTSAKVVRGYGRVIYLPPIEAPTTRAKR 816
            ....:... ||.|.|:|        |..|.. ||..|    |.||.          |....:.:|
Human   361 KEAGIAAE-SLGEMAES--------SGVSEE-AAENP----KSVRE----------ECIPMKRRR 401

  Fly   817 RAQFPSAPGMAATSSSDAGNLSFGESSLDASINQPLNTSSLSNDSQPGSGPKRPNPREPSMARRS 881
            ||:.          .|.|..|   ||..|...:.|..|:    ::.|..|...|    |...:.:
Human   402 RAKL----------CSSAETL---ESHPDIGKSTPQKTA----EADPRRGVGSP----PGRKKTT 445

  Fly   882 TAPRRSKKLDASQN--------------NDPDASESQEDDDDPNKLWCIC----RQPHNNRFMIC 928
            .:..||:|.||:..              ..|||| .:|.::.....|.:.    |..:|.:|.:.
Human   446 VSMPRSRKGDAASQFLVFCQKHRDEVVAEHPDAS-GEEIEELLRSQWSLLSEKQRARYNTKFALV 509

  Fly   929 CDLCEDWFHGTCVGV----TKAMGTDMENKGIDWKCPKCVKRQEE---RSQPRITDMLVTRPTTQ 986
            ..:..:...|...|.    ||.:....|:...: ..|:...|.::   |.:..|||......:.:
Human   510 APVQAEEDSGNVNGKKRNHTKRIQDPTEDAEAE-DTPRKRLRTDKHSLRKRDTITDKTARTSSYK 573

  Fly   987 PEQRPSETKVLTTTAEIVQVAAPSAPRRTLPVVLTVASSPMRIPMAKPAKKFPTGAISHQQQQQL 1051
            ..:..|..|....|..:.....|...|..   ..|.|||.:....:..    |:.:::..:
Human   574 AMEAASSLKSQAATKNLSDACKPLKKRNR---ASTAASSALGFSKSSS----PSASLTENE---- 627

  Fly  1052 NFIRLGPSPGKRISET-----------------------------LCVVCKRPAS---------- 1077
                :..|||...||:                             :|.:|::|.|
Human   628 ----VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCG 688

  Fly  1078 ----------------------TSSVY-------------------CG----EECIRKY------ 1091
                                  .|.::                   ||    |.|::||
Human   689 AFHLACLGLSRRPEGRFTCSECASGIHSCFVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFE 753

  Fly  1092 -------AQSAIQAHAAT-KGPLPQN---------------------AGAQSLLNNS------FD 1121
                   ..|.:..||:. ..|.|..                     ||...:.:||      |.
Human   754 SRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFT 818

  Fly  1122 AKKNKKKDLFEDVLRQADTVSKVERINV----FERKSGRVITGHMAPSAHQFRKWLQENP---SF 1179
            |:|.|:..               ..:||    ...|.|.::.....|:|.        :|   :.
Human   819 ARKGKRHH---------------AHVNVSWCFVCSKGGSLLCCESCPAAF--------HPDCLNI 860

  Fly  1180 EVLPSGT--VQSADAEKRL-------LKGAPEAATSTSEPAVLGVAKKPPEGPAKLSHPQNT--T 1233
            | :|.|:  .....|.|:|       :|              ||..:   ..||::.||:|.  .
Human   861 E-MPDGSWFCNDCRAGKKLHFQDIIWVK--------------LGNYR---WWPAEVCHPKNVPPN 907

  Fly  1234 VQ-ASHQLGISSVRPLAKKD-----KEKTTPTVQAPTPNRIAAGKPEPVRIGIRRSLREQLL--- 1289
            :| ..|::|...|.....||     :.:..|.::....:|.     :.|| ||.|..:..|.
Human   908 IQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRY-----QGVR-GIGRVFKNALQEAE 966

  Fly  1290 ARI------KEAQAAEENSGQPTTQWPTV--LEVDQFVKNVELEMFNSFGRDV------------ 1334
            ||.      :||:..:|:..:|    |..  ::|::....|::     :..|:
Human   967 ARFREIKLQREARETQESERKP----PPYKHIKVNKPYGKVQI-----YTADISEIPKCNCKPTD 1022

  Fly  1335 ----GAKYKAKYRSLMFNIKDRKNRTLFEKICAKQVEPR----QLVRMTPEQLASQELAK----- 1386
                |...:...|.|||.             |..||.|.    |....|..|....::.|
Human  1023 ENPCGFDSECLNRMLMFE-------------CHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKG 1074

  Fly  1387 WREEENRHQLDMIKKSELDLLACAQNYVVKTHKGEEVIAT-----KVDV------TLPEENVSEA 1440
            |.....|.    |:|.|.     ...||.:....||.:|.     :.|:      |:.::.:.:|
Human  1075 WGLVAKRD----IRKGEF-----VNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDA 1130

  Fly  1441 SSMAD-TKQTSLVSEPSTSTL-----------------------------------ERSTSREKA 1469
            ....: ::..:...:|:..||                                   |::..|..|
Human  1131 GPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGA 1195

  Fly  1470 G----------------SSKEKRHKSHKHHHRKRSRSRSNSRGRSVDKRHRRQHNEGGEQP---- 1514
            .                ||:||..|:.|  ..:|.|::...:.:|.|:..|  ..:||:..
Human  1196 SNCSGFLGDRPKTSTTLSSEEKGKKTKK--KTRRRRAKGEGKRQSEDECFR--CGDGGQLVLCDR 1256

  Fly  1515 ------------GSGEREHRSRE----------KQSRERDEIVPSPLPKKRDENDQSPVPKKTAE 1557
                        |.|:|.....|          |.|.....:.|:...|   |:........|.:
Human  1257 KFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCK---EHQDGTAFSCTPD 1318

  Fly  1558 KKTEASAYNLVDQILESEKTVEQAANLGKPK 1588
            .::....::|....:.|.||.:.....||||
Human  1319 GRSYCCEHDLGAASVRSTKTEKPPPEPGKPK 1349

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.