DRSC/TRiP Functional Genomics Resources

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Protein Alignment pps and Kmt2e

DIOPT Version :9

Sequence 1:NP_001247075.1 Gene:pps / 41524 FlyBaseID:FBgn0082831 Length:2018 Species:Drosophila melanogaster
Sequence 2:NP_081260.1 Gene:Kmt2e / 69188 MGIID:1924825 Length:1868 Species:Mus musculus


Alignment Length:1573 Identity:305/1573 - (19%)
Similarity:472/1573 - (30%) Gaps:548/1573 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   726 STEPGTLD-AIVSMPTSIEPVDVPQVQAHTNLLPN---ASLTEPAQSMTSLPIACSTPSRSVAAS 786
            :||...|: |..|.|.|:|.  .|.|...:|..|:   .|.:..:.|...||.|    ..:..|.
Mouse    11 TTETSYLEMAAGSEPESVEA--SPVVVEKSNSFPHQLYTSSSHHSHSYIGLPYA----DHNYGAR 69

  Fly   787 TPPTSAKVVRGYGRVIYLPPIEAPTTR--AKRRAQFPSAPGMAATSSSDAGNLSFGESSLDASIN 849
            .|||              ||...|.:.  :|......:.|....|||:                 
Mouse    70 PPPT--------------PPASPPPSGLISKNEVGIFTTPNFDETSSA----------------- 103

  Fly   850 QPLNTSSLSNDSQPGSGPKRPNPREPSMARRSTAPRRSKKLDASQNNDPDASESQEDDDDPNKLW 914
               .|.|.|.|...|:...|                                             
Mouse   104 ---TTISTSEDGSYGTDVTR--------------------------------------------- 120

  Fly   915 CICRQPHNNRFMICCDLCEDWFHGTCVGVTKAMGTDMENKGIDWKCPKCVKRQEERSQPRITD-- 977
            |||...|::.:|||||.|..|.|..|      ||.|.::....:.|.:|        |||..|  
Mouse   121 CICGFTHDDGYMICCDKCSVWQHIDC------MGIDRQHIPDTYLCERC--------QPRSLDKE 171

  Fly   978 --MLVTRPTTQPEQRPSETKVLTTTAEIVQVAAPSAPRRTLPVVLTVASSPMRIPMAKPAKKFPT 1040
              :|:.|  .:.|.........|.:.:.|.|...:|.:.| |..:|:.:|  |:|.....::..:
Mouse   172 RAVLLQR--RKRENMSDGDTSATESGDEVPVELYTAFQHT-PTSITLTAS--RVPKVTDKRRKKS 231

  Fly  1041 GAISHQQQQQLNF------IRLGPSPGKRISETLCVVCKRPASTSSVYCGE-------------- 1085
            |      :::.||      .|.|.....|:..:...:  .|:|.||.:..|              
Mouse   232 G------EKEQNFSKCKKAFREGSRKSSRVKGSAPEI--DPSSDSSNFVWETKIKAWMDRYEEAN 288

  Fly  1086 -----ECIRKYAQSAIQAHAATKGPLPQNAGAQSLLNNSF------DAKKNKK-----KDLFEDV 1134
                 |.:::.||...|...:.......|....|..|:.|      ..:||||     |||..|.
Mouse   289 NNQYSEGVQREAQRLAQRLGSGNDSKDMNKSELSTNNSLFRPPVESHIQKNKKILKSAKDLPPDA 353

  Fly  1135 L----------------------RQADTVSKVERINVFER--------KSGRVITGHMAPSA--- 1166
            |                      |....|....:.:..|.        ...|.|.....|:|   
Mouse   354 LIIEYRGKFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVR 418

  Fly  1167 HQFRK-------------------------------------WLQENPSFEVLPSGTVQSADA-- 1192
            |:..:                                     .|:|||...||...:..:.:.  
Mouse   419 HEIEEGTIHLYIYSIQSIPKGTEITIAFDFDYGNCKYKVDCACLKENPECPVLKRSSESTENINS 483

  Fly  1193 --EKRLLKGAPEAATSTSE-----------PAVLGVAKKPPEGPAKLSHPQNTTVQASHQLGISS 1244
              |.|..||..|..||..:           .......:.|.....||| |...:|..:.:     
Mouse   484 GYETRRKKGKKEKDTSKEKDIQNQNMTLDCEGTNNKIRSPETKQRKLS-PLRLSVSNNQE----- 542

  Fly  1245 VRPLAKKDKEKTTP---TVQAPTPNRIAAGKPEP--------------VRIGIRRSLREQLLARI 1292
              |....|.|:.||   .|:..:..:||..|.:.              .|:..|...|||.|.||
Mouse   543 --PDFIDDMEEKTPISNEVEMESEEQIAERKRKMTREERKMEAILQAFARLEKREKRREQALERI 605

  Fly  1293 K-----------------EAQAAEENSGQPTTQWPTVLEVDQFVKNVELEMFNSFGRD---VGAK 1337
            .                 :|:..:|...:.|...|...:|::      .:...||.|.   :|. 
Mouse   606 STAKTEVKPECKESQVIADAEVVQEQVKEETAIKPAAAKVNR------TKQRKSFSRSRTHIGQ- 663

  Fly  1338 YKAKYRSLMFNIKDRKNRTLFEKICAKQVEPRQLVRMTPEQLASQELAKWREEEN---------- 1392
                        :.|::||:  .:|:.         :.|.....:.|::..|.||          
Mouse   664 ------------QRRRHRTV--SMCSD---------IPPSSPDIEVLSQQNEIENTVLAIEPETE 705

  Fly  1393 RHQLDMIKKSELDLL-ACAQNYVVKTHKGEEVIATKVDVTLPEENVSEASSMADTKQTSLVSEPS 1456
            ....::|.::|:..| .|...| .||.|           .|..|.:||.:........||...|.
Mouse   706 TAVAEIIPEAEVPALNKCPTKY-PKTKK-----------HLVNEWLSEKNEKTGKPSDSLSERPL 758

  Fly  1457 TSTLERSTSREKAGSSKEKRHKSH-----KHH---------HRKRSRSRSNSRGRSVDKRHRRQH 1507
            ..|.:......:..|.....:..|     ||:         .:||.:..:.:...|..||..:|.
Mouse   759 RITTDPEVLATQLNSLPGLTYSPHVYSTPKHYIRFTSPFLSEKKRRKETTENISGSCKKRWLKQA 823

  Fly  1508 NEGGEQPGSGEREHRSREKQSRERDEIVPSPLPKKRDEN-------DQSPVPKKTAEKKTEASAY 1565
            .| .|......|.|...:::||.         |....||       |...:|..|...| :...|
Mouse   824 LE-EENSTILHRYHSPCQERSRS---------PTVNGENKSPLLLSDSCSLPDLTTPLK-KRRLY 877

  Fly  1566 NLVDQILESEKTVEQAANLGKPKPSPKPLPTL-------PSSLKAPEPMDNYSRYLHGLTTSSLW 1623
            .|:|.......|         |.|||...||.       |:....|....:...|.:|.  ..::
Mouse   878 QLLDTAYSESST---------PTPSPYATPTHTDITPTDPAFATPPRIKSDDETYRNGY--KPIY 931

  Fly  1624 SGTLKMI-----DLADFEIVMYPVQG----NC--HQLGNLMPSQMDVIGRITRVNVWEY----IK 1673
            |....:.     :...||.:..|...    .|  :|.|...||.|..:|.....|:.|.    ||
Mouse   932 SPVTPVTPGTPGNTMHFENISSPESSPEIKRCTYNQEGYDRPSNMLTLGPFRNSNLTELGLQEIK 996

  Fly  1674 KLKKSPTKEVVIVN-------------------IFPAS---PSETYKFD---------------- 1700
            .:..:..:....||                   :.||:   ..||...|                
Mouse   997 TIGYTSPRSRTEVNRPCPGEKESVSDLQLGLDAVEPAALQKSMETPAHDRTEPSNQLDSTHSGRG 1061

  Fly  1701 -LFFEYLDSRQRLGVLGVDSDQIRDF---YIFPLGSGDKLPPALQTAEPVPFYEEAQRPNTLLGI 1761
             ::..::.|..|.||....:..:||.   :....|.|      .:.:|.....::.......||.
Mouse  1062 TMYSSWVKSPDRTGVNFSVNSNLRDLTPSHQLETGGG------FRVSESKCLIQQDDTRGMFLGA 1120

  Fly  1762 IVRCLSKRPADAVPS---------------TPSVPTPVPALSSKVAKRSRSSISYPAQSSPKRKI 1811
            .|.|.|:   |.:.|               ||..|.         .|:..|.:.|     .||:.
Mouse  1121 AVFCTSE---DGLASGFGRTVNDNLIDGSCTPQNPP---------QKKKVSLLEY-----RKRQR 1168

  Fly  1812 STHSTSSKDDEFDIDAIIKAPIAKLQKTAPKVVPQPSVPNDADEPYSPGGSDDELVPSAPQRPND 1876
            ....:.||.:.|   |:|            .|.|.||        .|...|.|..|.|:..    
Mouse  1169 EARKSGSKPENF---ALI------------SVSPHPS--------GSLSSSGDGCVHSSEN---- 1206

  Fly  1877 LERQVNEINKQIAAQQMEIAGLLKVEPTGSASSSNVLAAISIPANLSKILASIKDKTNLPSSADD 1941
                         .:|.|....|.:.|..:|:::...||.|        .:|.:..:|.|....:
Mouse  1207 -------------GEQAENQASLPLPPPAAAAAATAAAAYS--------ASSEEGSSNCPVKDAN 1250

  Fly  1942 GDEEYNPEDDITATSSFASKKPRSKGRLAHLS----------EAELLSMVPDNLAGVIPRSSRTR 1996
            ..|:.:||...||::|....:.||..|...||          |:..:|..|.::..  |.||.:.
Mouse  1251 SSEKKDPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQS--PPSSHSN 1313

  Fly  1997 H--QLAQSPLTPT 2007
            |  |:....|.|:
Mouse  1314 HIPQVHAQSLAPS 1326

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppsNP_001247075.1 TNG2 <827..965 CDD:227367 27/137 (20%)
PHD_PHF3_like 914..963 CDD:277027 17/48 (35%)
BRK 1142..1186 CDD:197800 12/91 (13%)
TFIIS_M 1274..1396 CDD:284835 26/165 (16%)
SPOC 1623..1729 CDD:285043 28/162 (17%)
Kmt2eNP_081260.1 HCFC1-binding motif (HBM). /evidence=ECO:0000250|UniProtKB:Q8IZD2 63..66 0/2 (0%)
PHD_MLL5 120..163 CDD:277025 18/93 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 178..197 3/20 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 217..268 11/60 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 308..329 3/20 (15%)
SET_KMT2E 323..451 CDD:380959 19/127 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 472..504 7/31 (23%)
Smc 483..>716 CDD:224117 49/270 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 646..682 9/65 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 884..924 9/48 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1038..1068 3/29 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1165..1222 20/96 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1236..1315 20/80 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1334..1565
Herpes_BLLF1 <1350..1609 CDD:282904
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1585..1842
PRK03427 <1749..>1857 CDD:235124
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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