DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pps and NSD1

DIOPT Version :9

Sequence 1:	NP_001247075.1	Gene:	pps / 41524	FlyBaseID:	FBgn0082831	Length:	2018	Species:	Drosophila melanogaster
Sequence 2:	NP_071900.2	Gene:	NSD1 / 64324	HGNCID:	14234	Length:	2696	Species:	Homo sapiens

Alignment Length:	1837	Identity:	341/1837 - (18%)
Similarity:	575/1837 - (31%)	Gaps:	635/1837 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   470 LPVKRPPLP-TTPANSNVRRMPAVQLGRIVNSPQEVKEIIIN--KNMASP-KGVFTNLNTLLGED 530
            ||.:...|| :.|.|              :::|::......|  .|.:.| .|....|:|:.|..
Human     7 LPRRNCLLPFSNPVN--------------LDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTS 57

  Fly   531 NNAATKSSP---VPLRHRAVM-----------------SPSTPRSSYNQQMSPIVVPVPAQAHTP 575
            .||..:.||   :|||....:                 |...|..|.::..:|||.
Human    58 QNAYGQDSPSCYIPLRRLQDLASMINVEYLNGSADGSESFQDPEKSDSRAQTPIVC--------- 113

  Fly   576 SKGFMPIGVDTAQSHKLPAQIVIETHQS---SSELAAENDKQLDLINSIVQDELLKSTLVEQPVV 637
                      |:.|...|..:.::...|   |.||..:..|.:.  |..:..|  ..|.|:
Human   114 ----------TSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIK--NGFLHFE--NFTCVD---- 160

  Fly   638 NADEDIPKLVKMLESTAADLDPPPVSLPTNIFPAPEMQGVGNAAAADPNNIMDTANEDEITADFL 702
            :||.|            :::||                                  |..:|.|
Human   161 DADVD------------SEMDP----------------------------------EQPVTED-- 177

  Fly   703 QHVVGLIEEDKQFEAEVVKQVLASTEPGTLDAIVSMPTSIEPVDVPQVQAHTNLLPNASLTEPAQ 767
                           |.::::...|:                             .||:.....:
Human   178 ---------------ESIEEIFEETQ-----------------------------TNATCNYETK 198

  Fly   768 SMTSLPIAC-----STP-SRSVAASTPPTSAKVVRGYGRVIYLPPIEAPTTRAKRRAQFPSAPGM 826
            |...:.:|.     ||| ||..|..:|              :||  .||.|..::..|.....|.
Human   199 SENGVKVAMGSEQDSTPESRHGAVKSP--------------FLP--LAPQTETQKNKQRNEVDGS 247

  Fly   827 AATSSSDAGNLSFGESSLDASINQPLNTSSLSNDSQPGSGPKR-PNPRE-PSMARRSTAPRRSKK 889
            ...::......|.|::::  :|.:.||:.:||....|.|.... .|..| |..:..||    |::
Human   248 NEKAALLPAPFSLGDTNI--TIEEQLNSINLSFQDDPDSSTSTLGNMLELPGTSSSST----SQE 306

  Fly   890 LDASQNNDPDASESQEDDDDPNKLWC-ICRQPHNNRFMICCDLCEDWFHGTCVGV---------- 943
            |...|..........|..|   .:|. ..|:|     ...|.:|.|....|...:
Human   307 LPFCQPKKKSTPLKYEVGD---LIWAKFKRRP-----WWPCRICSDPLINTHSKMKVSNRRPYRQ 363

  Fly   944 --TKAMGTDMENKGIDWKCPKCVKRQEERSQPRITDMLVTRPTTQ--------PEQRPSETKVLT 998
              .:|.|...|..   |...|.:...|.|.|.....:|..|...:        |::..|:.:...
Human   364 YYVEAFGDPSERA---WVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASV 425

  Fly   999 TTAEIVQVAAPSAPRRTLPVVLTVASSPMRIPMAKPAKKFPTGAISHQQQQQLNFIRLGPSPGKR 1063
            ..||...|...|..|:.:|                       |:|....::.:.|......|...
Human   426 GLAEQYDVPKGSKNRKCIP-----------------------GSIKLDSEEDMPFEDCTNDPESE 467

  Fly  1064 ISETLCVVCKRPASTSSVYCGEE----CIRKYAQSA---------------IQAHA-ATKGPLPQ 1108
             .:.|...|.:..:..|.:..:|    |.:..|:.:               .:||. ..:|.:|:
Human   468 -HDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPE 531

  Fly  1109 NAGAQSLLNNSFDAKKNKKKDLFEDVLRQADT-------------VSKVERINVFERKSGRVITG 1160
            |.|...:..:..|.:.:.:.....:.|..::|             .:|.|    ||..:|..:.|
Human   532 NLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKE----FETSNGDSLLG 592

  Fly  1161 HMAPSAHQFRKWLQE-NPSFEVLPSGT------VQSADAEKRLLKGAPEAATSTSEPAVLGVAKK 1218
              .|......|..:| |.....|..|:      :.:.|.|||          |.|    :.:...
Human   593 --LPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKR----------SDS----ISICTT 641

  Fly  1219 PPEGPAKLSHPQNTTVQASHQLGISSV-----RPLAKKDKEKTTPTVQAPTPNRIAAGKPEPVRI 1278
            ..:|.:.|...::::...:..|.|...     ..|:.:..||...:..|.|..|:.| |.:|:
Human   642 SDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKA-KQKPL-- 703

  Fly  1279 GIRRSLREQLLARIKEAQAAEENS-------------GQPTTQWPTVLEVDQFVKNVELEMFNSF 1330
             |..|..:.|:...|.|:...|.|             .:|.:.:.......:|..:..:...||.
Human   704 -ISNSHTDHLMGCTKSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSL 767

  Fly  1331 GRDVGAKYKA---------KYRSLMFNIKDRKNRTLFE----------KICAKQVEPRQLVRMTP 1376
            .:. ||..:|         |:||:  ..|.::|..:.|          |.|:...:...|..::
Human   768 IKG-GAANQALLHSKSKQPKFRSI--KCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASIS- 828

  Fly  1377 EQLASQELAKWREEENRHQLDMIKKSELDLLACAQNYVVKTHKGEEVIATKVDVTLPE------- 1434
                                   |..::|.|....|...||....::....|...|.|
Human   829 -----------------------KSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYR 870

  Fly  1435 ---ENVSEASSMADTK---------QTSLVSEP--STSTL------------------------- 1460
               |:||::.:...:|         |..:..||  ..|||
Human   871 SLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVS 935

  Fly  1461 ERSTSR------EKAGSSKEKRHKSHKHHHRKRSRSRSNSRGRSVDKRHRRQHNEGGEQPGSGE- 1518
            .||..|      ...|.||........|:..|:.....||...|         ..||:...|||
Human   936 YRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPS---------PSGGDSALSGEL 991

  Fly  1519 --------REHRSREKQSRERDEIV-------PSPLPKKRD----ENDQSPVPKKTAEKKTEASA 1564
                    .:.|......:.|.:.|       ..|..|.||    :..::.|.:|..:.:.:...
Human   992 SASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKL 1056

  Fly  1565 YNL----VDQILESEKTVEQAANL--GKPKPSPKPLPTLPSSLKAPEPMDNYSRYLHGLTTSSLW 1623
            ..|    :|.:|:.::  |:..:|  |...||.:....:...|.: |..|::|. :|       :
Human  1057 NQLPSVTLDAVLQGDR--ERGGSLRGGAEDPSKEDPLQIMGHLTS-EDGDHFSD-VH-------F 1110

  Fly  1624 SGTLKMIDLA-------DFEIVMYPVQGNCHQLGNLMPSQMDVIGRITRV---NVWEYIKKLKKS 1678
            ...:|..|..       .||      .|...:|.::|.|:.|.:..:.:|   ..|:.:.:.:..
Human  1111 DSKVKQSDPGKISEKGLSFE------NGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTK 1169

  Fly  1679 PTKEVVIVNIFPASPSETYKFDLFFEYLDSRQRLGVLGVDSDQI---RDFYIFPLGSGDKLPPAL 1740
            |.|                :.:.|.|..:|.....|| :.||.:   ||  .||   ..:.|.|.
Human  1170 PRK----------------RMNRFKEKENSECAFRVL-LPSDPVQEGRD--EFP---EHRTPSAS 1212

  Fly  1741 QTAEPV-------------PFYEEAQRPNTLLGIIVRCLSKRPADAVPS-TPSVPTPVPALSS-- 1789
            ...||:             |......:.:..:|    .:.|.|  .:|| ||....|.||:.|
Human  1213 ILEEPLTEQNHADCLDSAGPRLNVCDKSSASIG----DMEKEP--GIPSLTPQAELPEPAVRSEK 1271

  Fly  1790 -KVAKRSRSSISY---------PAQSSPKRKISTHSTSSKDDEFDIDAIIKAPIAKLQKTAP-KV 1843
             ::.|.|:..:.|         |.:...|.:...|..||:.:|       ::.:|:.:.:|. |.
Human  1272 KRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEE-------ESLLARGRSSAQNKQ 1329

  Fly  1844 VPQPSVPNDADEP-----YSP-----------GGSDDEL------VPSAPQRPNDLERQVNEINK 1886
            |.:.|:.:..:||     .:|           ||...||      ||.||           |::.
Human  1330 VDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAP-----------EVSP 1383

  Fly  1887 QIAAQQMEIAGLLKV----------EPTGSASSSNVLAAISIPANLSKILASIKDKTNLPSSADD 1941
            :.|.:..|:  |:|.          :||.....||.|                 |...:|...|.
Human  1384 RPALESEEL--LVKTPGNYESKRQRKPTKKLLESNDL-----------------DPGFMPKKGDL 1429

  Fly  1942 G-----DEEYNPEDDIT---ATS---SFAS------KKPRSKGRLAH-LSEAELLSMVPDNLAGV 1988
            |     .|..:.|:.||   |||   .|..      .|||.:.|..| .::.:...:..|:.:..
Human  1430 GLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKE 1494

  Fly  1989 IPRS--SRTRHQLAQSP 2003
            ||.|  ....|:.|.||
Human  1495 IPGSEGELMPHRTATSP 1511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pps	NP_001247075.1	TNG2	<827..965	CDD:227367	31/152 (20%)
		PHD_PHF3_like	914..963	CDD:277027	11/61 (18%)
		BRK	1142..1186	CDD:197800	11/44 (25%)
		TFIIS_M	1274..1396	CDD:284835	24/153 (16%)
		SPOC	1623..1729	CDD:285043	22/118 (19%)
NSD1	NP_071900.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..252		14/60 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..311		9/33 (27%)
		MSH6_like	319..429	CDD:99898	21/120 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	487..514		3/26 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	872..891		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	936..1035		23/107 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1067..1093		6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1112..1134		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1243..1272		11/34 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1294..1344		13/56 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1382..1428		11/64 (17%)
		ING	<1431..1587	CDD:331088	21/81 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1480..1534		8/32 (25%)
		PHD1_NSD1_2	1545..1587	CDD:277118
		PHD2_NSD1	1592..1638	CDD:277120
		PHD3_NSD1	1639..1692	CDD:277123
		PHD4_NSD1	1709..1748	CDD:277126
		WHSC1_related	1754..1848	CDD:99899
		AWS	1891..1941	CDD:197795
		SET	1942..2065	CDD:214614
		S-adenosyl-L-methionine binding	1952..1954
		S-adenosyl-L-methionine binding	1994..1997
		S-adenosyl-L-methionine binding	2020..2021
		Inhibits enzyme activity in the absence of bound histone	2060..2066
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2091..2111
		PHD5_NSD1	2120..2162	CDD:277129
		Atrophin-1	<2208..2574	CDD:331285
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2213..2422
		DNA_pol3_gamma3	<2438..2663	CDD:331207
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2464..2499
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2553..2575
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2595..2616
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2665..2696
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030