DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pps and PHF20

DIOPT Version :9

Sequence 1:	NP_001247075.1	Gene:	pps / 41524	FlyBaseID:	FBgn0082831	Length:	2018	Species:	Drosophila melanogaster
Sequence 2:	NP_057520.2	Gene:	PHF20 / 51230	HGNCID:	16098	Length:	1012	Species:	Homo sapiens

Alignment Length:	822	Identity:	157/822 - (19%)
Similarity:	277/822 - (33%)	Gaps:	213/822 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 ETDALMEVIRNDHNY-------TPFTSP-EQLKNHK---RDEKMAMEMQAQSRKIIMQA-----P 239
            |...|:...|.:|.|       :|:..| |:::..|   .:|..:.|.|...:.:...:     |
Human    40 EGKVLIHFKRWNHRYDEWFCWDSPYLRPLEKIQLRKEGLHEEDGSSEFQINEQVLACWSDCRFYP 104

  Fly   240 GSVKLINAKKRVQAIPLSPVQVKVQRLPVKPHQVQQ--AAQLQPKVQLIRKPIHSPLPRQKPEII 302
            ..|..:|............|...|:.:.||.....|  ....:||....:....||..|:|.:..
Human   105 AKVTAVNKDGTYTVKFYDGVVQTVKHIHVKAFSKDQNIVGNARPKETDHKSLSSSPDKREKFKEQ 169

  Fly   303 ANNSVNARLRPTRAPVKVIAPPVQEYIEDDDDAQSSDSAEEENADKAYDSEEMSEESDEFQESDN 367
            ...:||.:......|:|....|.|    .|.:.:...|.:.:.::|:....| .|:.:...|:|.
Human   170 RKATVNVKKDKEDKPLKTEKRPKQ----PDKEGKLICSEKGKVSEKSLPKNE-KEDKENISENDR 229

  Fly   368 DRDSDMDFDMR---------HSNRRNPNKRKRVRKVVRQTPSKPMKPLPPPPTTPQHFPELKKRK 423
            :...|...|.:         ..|.|.| ||||.|               ||...|   ..:....
Human   230 EYSGDAQVDKKPENDIVKSPQENLREP-KRKRGR---------------PPSIAP---TAVDSNS 275

  Fly   424 EVLEPKAPQIGQIIQMPATKSVPAVFALGRGLPSTSFLKIRPTHQSLPVKRPPLPTTPANSNVRR 488
            :.|:|..      :::...|       :.:|.             .:|:|||.|..
Human   276 QTLQPIT------LELRRRK-------ISKGC-------------EVPLKRPRLDK--------- 305

  Fly   489 MPAVQLGRIVNSPQEVKEIIINKNMASPKGVFTNLNTLLGEDNNAATKSSPVPLR--HRAVMSPS 551
                      ||.||.     :||.:.        ||   :.:.:..:||.:...  |. ::.|
Human   306 ----------NSSQEK-----SKNYSE--------NT---DKDLSRRRSSRLSTNGTHE-ILDP- 342

  Fly   552 TPRSSYNQQMSPIVVPVPAQAHTPSKGFMPIGVDTAQSHKLPAQIVIETHQSSSELAAEN----- 611
                  :..:|.:|...|.|....|         |.:|.:...:..:|..|.||.|...:
Human   343 ------DLVVSDLVDTDPLQDTLSS---------TKESEEGQLKSALEAGQVSSALTCHSFGDGS 392

  Fly   612 -DKQLDLINSIVQDELLKSTLVEQPVVNADEDIPKLVKMLESTAADLDPPPVSLPTNIFPAPEMQ 675
             ...|:|....:.:..:|:           |....||::.|.:..::        ||.|...:..
Human   393 GAAGLELNCPSMGENTMKT-----------EPTSPLVELQEISTVEV--------TNTFKKTDDF 438

  Fly   676 GVGNAAAADPNNIMDTANEDEITADFLQHVVGLIEEDKQFEAEVVKQVLASTEPGTLDAIV---- 736
            |..||.|.|                 |.|         :|..:||..:....:...|...:
Human   439 GSSNAPAVD-----------------LDH---------KFRCKVVDCLKFFRKAKLLHYHMKYFH 477

  Fly   737 SMPTSIEPVDVPQVQAHTNLLPNASLTEPAQSMTSLPIACSTPSRSVAASTPPTSAK---VVRGY 798
            .|..|:||.:.|..:......|:|| .:|:|.        :...:.|:||:|.|..|   ..:.:
Human   478 GMEKSLEPEESPGKRHVQTRGPSAS-DKPSQE--------TLTRKRVSASSPTTKDKEKNKEKKF 533

  Fly   799 GRVIYLPPIEAPTTRAKRRAQFPSAPGMAATSSSDAGNLSFGESSLDASINQPLNTSSLSNDSQP 863
            ...:.:.|.:....:.|.:.:.|.:..::.||...:...:|..:...:|....::.|...:..:.
Human   534 KEFVRVKPKKKKKKKKKTKPECPCSEEISDTSQEPSPPKAFAVTRCGSSHKPGVHMSPQLHGPES 598

  Fly   864 GSGPKRPNPREPSMARRSTA-------PRRSKKLDASQNNDPDASESQEDDDDPNKLWCICRQPH 921
            |....:....|......|::       ....:.:|.:.|  ||.....:|..|...:.|||....
Human   599 GHHKGKVKALEEDNLSESSSESFLWSDDEYGQDVDVTTN--PDEELDGDDRYDFEVVRCICEVQE 661

  Fly   922 NNRFMICCDLCEDWFHGTCVGVTKAMGTDMENKGIDWKCPKC 963
            .|.|||.|:.|:.|.||.|:|:.:      ||....:.|..|
Human   662 ENDFMIQCEECQCWQHGVCMGLLE------ENVPEKYTCYVC 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pps	NP_001247075.1	TNG2	<827..965	CDD:227367	32/144 (22%)
		PHD_PHF3_like	914..963	CDD:277027	17/48 (35%)
		BRK	1142..1186	CDD:197800
		TFIIS_M	1274..1396	CDD:284835
		SPOC	1623..1729	CDD:285043
PHF20	NP_057520.2	MBT	3..68	CDD:302657	6/27 (22%)
		TUDOR	90..135	CDD:119391	6/44 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..336		51/278 (18%)
		DUF3776	176..259	CDD:289391	17/88 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..611		25/138 (18%)
		PHD_PHF20	654..697	CDD:277104	17/48 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	866..912
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030