DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pps and PHF20L1

DIOPT Version :9

Sequence 1:	NP_001247075.1	Gene:	pps / 41524	FlyBaseID:	FBgn0082831	Length:	2018	Species:	Drosophila melanogaster
Sequence 2:	XP_011515377.1	Gene:	PHF20L1 / 51105	HGNCID:	24280	Length:	1023	Species:	Homo sapiens

Alignment Length:	910	Identity:	176/910 - (19%)
Similarity:	283/910 - (31%)	Gaps:	309/910 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 RKPKERPQI---VGLRVE------QFYADNTADMVVKNALKLAGVSVYKRTAETDALMEVIRNDH 203
            :||..||.|   :|.|:|      ::|......:..:               |...|:...|..|
Human     3 KKPPNRPGITFEIGARLEALDYLQKWYPSRIEKIDYE---------------EGKMLVHFERWSH 52

  Fly   204 NY-----------TPFTSPEQLKNHKRDEKMAMEMQAQSRKIIMQA-----PGSVKLINAK---- 248
            .|           .|...|...|...:||:...:.:|....:....     |..::.||.:
Human    53 RYDEWIYWDSNRLRPLERPALRKEGLKDEEDFFDFKAGEEVLARWTDCRYYPAKIEAINKEGTFT 117

  Fly   249 -----------KR--VQAIPLSP-----VQVKVQR-----LPVKP-HQVQQAAQLQPKVQLIRKP 289
                       ||  ::|:|...     .|||.|.     .|:.| ....|:...:..:.|::..
Human   118 VQFYDGVIRCLKRMHIKAMPEDAKGQFLFQVKSQHPLSWCCPIDPAGSCNQSMGSEDWIALVKAA 182

  Fly   290 IHSPLPRQ---KPEIIANNSVNARLRPTRAPVKVIAPPVQEYIEDDDDAQSSDSAEEENADKAYD 351
            ..:....:   ||...||::.: :.:..|...||  |..:|        ::|......:.:|
Human   183 AAAAAKNKTGSKPRTSANSNKD-KDKDERKWFKV--PSKKE--------ETSTCIATPDVEK--- 233

  Fly   352 SEEMSEESDEFQESDNDRDSDMDF---DMRHSNRRNPN-------KRKRVRKVVRQTPSKPM--- 403
            .|::...|:.|.....:....|.|   :...||:|..|       ||.|:.|:.....||.:
Human   234 KEDLPTSSETFVGLHVENVPKMVFPQPESTLSNKRKNNQGNSFQAKRARLNKITGLLASKAVGVD 298

  Fly   404 -----------KPLPPPPTTPQHFPELKKRKEVLEPKAPQIGQIIQMPATKSVPAVFA--LGRGL 455
                       .|:.....:|:  |:.:|:.|.          .|...|....||:.:  |..|.
Human   299 GAEKKEDYNETAPMLEQAISPK--PQSQKKNEA----------DISSSANTQKPALLSSTLSSGK 351

  Fly   456 PSTSFLKIRPTHQSLPVKRPPLPTTPANSNVRRMPAVQLGRIVNSPQEVKEIIINKNM----ASP 516
            ..:...|......|..:|.|..|.:|....|..:..|         .::...:|||..    .:|
Human   352 ARSKKCKHESGDSSGCIKPPKSPLSPELIQVEDLTLV---------SQLSSSVINKTSPPQPVNP 407

  Fly   517 KGVFTN---------LNTLLGEDNNAATKSSPVPLRHRAVMSPSTPRSSYNQQMSPIVVPVPAQA 572
            ...|.:         |.||...|::....|||.|.....|.|    .||.|||.|. |..||..|
Human   408 PRPFKHSERRRRSQRLATLPMPDDSVEKVSSPSPATDGKVFS----ISSQNQQESS-VPEVPDVA 467

  Fly   573 HTPSKGFMPIGVDTAQSHKLPAQIVIETHQSSSELAAENDKQLDLINSIVQDELLKSTLVEQPVV 637
            |.|.:...|.         ||.                              :|.:.:.|..||.
Human   468 HLPLEKLGPC---------LPL------------------------------DLSRGSEVTAPVA 493

  Fly   638 NADEDIPKLVKMLESTAADLDPPPVSLPTNIFPAPEMQGVGN-----AAAADPNNIMDTANEDEI 697
            :            :|:..:..|......|.:.|.|..:.:.:     |||...........||:.
Human   494 S------------DSSYRNECPRAEKEDTQMLPNPSSKAIADGRGAPAAAGISKTEKKVKLEDKS 546

  Fly   698 TADFLQHVVGLIEEDKQ---------FEAEVVKQVLASTEPGTLDAIVSMPTSIEPVDVPQVQAH 753
            :..|.:..    |:||:         :..:..|:.....:....|......:|:|.::
Human   547 STAFGKRK----EKDKERREKRDKDHYRPKQKKKKKKKKKSKQHDYSDYEDSSLEFLE------- 600

  Fly   754 TNLLPNASLTEPAQSMTSLPIACSTP-SRSVAASTPPTSAKVVRGYGRVIYLPPIEAPTTRAKRR 817
                                 .||:| :||..:|....|...             |..||
Human   601 ---------------------RCSSPLTRSSGSSLASRSMFT-------------EKTTT----- 626

  Fly   818 AQFPSAPGMAATSSSDAGNLSFGESSLDASINQPLNTSSLSNDSQPGSGPKRPNPREPSMARRST 882
            .|:|.|......|..:..::.|    ||.|..:.|   .||.|
Human   627 YQYPRAILSVDLSGENLSDVDF----LDDSSTESL---LLSGD---------------------- 662

  Fly   883 APRRSKKLDASQNNDPDAS---ESQEDDDDPNKL-WCICRQPHNNRFMICCDLCEDWFHGTCVGV 943
                      ..|.|.|::   |||::||..|:: .|||.....|.|||.|:.|..|.|..|:|:
Human   663 ----------EYNQDFDSTNFEESQDEDDALNEIVRCICEMDEENGFMIQCEECLCWQHSVCMGL 717

Fly 944 943
Human 718 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pps	NP_001247075.1	TNG2	<827..965	CDD:227367	31/121 (26%)
		PHD_PHF3_like	914..963	CDD:277027	13/30 (43%)
		BRK	1142..1186	CDD:197800
		TFIIS_M	1274..1396	CDD:284835
		SPOC	1623..1729	CDD:285043
PHF20L1	XP_011515377.1	MBT	3..68	CDD:302657	14/79 (18%)
		TUDOR	90..135	CDD:119391	5/44 (11%)
		DUF3776	214..322	CDD:289391	23/122 (19%)
		PHD20L1_u1	323..388	CDD:293265	15/74 (20%)
		PHD_PHF20L1	688..733	CDD:277103	13/30 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030