DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pps and phf20b

DIOPT Version :9

Sequence 1:	NP_001247075.1	Gene:	pps / 41524	FlyBaseID:	FBgn0082831	Length:	2018	Species:	Drosophila melanogaster
Sequence 2:	XP_005162050.1	Gene:	phf20b / 445482	ZFINID:	ZDB-GENE-040822-33	Length:	1030	Species:	Danio rerio

Alignment Length:	1348	Identity:	228/1348 - (16%)
Similarity:	376/1348 - (27%)	Gaps:	566/1348 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 EQFYADNTADMVVKNALKLAGVSV---YKRTAE----TDALMEVIRNDHNYTPFTSPEQLKNHKR 219
            :.||.....|.::|.   :.|:.|   .|::::    ..|.....:|:....|..:.....|..|
Zfish   113 DDFYTVKFFDGIIKT---VKGIKVKPFRKQSSDGRSNQQARKRADQNEKELKPKENGNSRHNSSR 174

  Fly   220 ----DEKMAMEMQAQSRKIIMQAP-----GSVKLINAKKRVQAIPLSPVQVKVQRLPVKPHQVQQ 275
                |.....|.:|.....:|...     |..|.....|.|....:|..:          ||..:
Zfish   175 HSVSDHDGESESEADEDTTVMDESTDLQNGGEKESTETKMVNDSEVSSAE----------HQPSE 229

  Fly   276 AAQLQPKVQLIRKPIHSPLPRQKPEIIANNSVNARLRPTRAPVKVIAPPVQEYIEDDDDAQSSDS 340
             .|.||.             ..|.|.:.|.:|..::.             :|..|:.|..|....
Zfish   230 -DQNQPS-------------EDKTENLENGNVEIKIE-------------EEEEEEMDGGQEEAK 267

  Fly   341 AEEENADKAYDSE-EMSEESDEFQESDNDRDSD-MDFDM----------RHSNRRNPNKRKRVRK 393
            ......||..:.: |.|:||....:....|.:| .:.:|          ..:.:.:|.||.|...
Zfish   268 VLHNGIDKNDEHKGEASDESPSLPKRTRSRTADGKEAEMVNGPELRKRRASTGQTSPAKRSRANS 332

  Fly   394 VV---RQTPSKPMKPLPPPPTTPQHFPELKKRKEVLEPKAPQIGQIIQMPATKSVPAVFALGRGL 455
            ..   .|||.||:|....|.|.     ::|..|              ..||.|..||..|  ...
Zfish   333 STDRNTQTPIKPVKSDSVPDTL-----DIKDEK--------------TSPAGKPAPAEEA--GST 376

  Fly   456 PSTSFLKIRPTHQSLPVKRPPLPTTPANSNVRRMPAVQLGRIVNSPQEVKEIIINKN-----MAS 515
            |..:....|..|         ||||   :...|.|..::  |.|.|..:..|.::.|     ||.
Zfish   377 PELAAALKRQVH---------LPTT---NKYSREPLYRV--IKNQPPPILSIELDHNPFKCKMAG 427

  Fly   516 PKGVFTNLNTLLGEDNNAATKSSPVPLRHRAVMSPSTPRSSYNQQMSPIVVPVPAQAHTPSKGFM 580
            ....|...:.|.........:|.|.|  .|.|.:.|:.:.|.:|:.......|.|..||||
Zfish   428 CLKSFRKASLLHYHMKYYHAQSDPSP--PRCVQTRSSDKQSPSQETPRRRRTVSASHHTPS---- 486

  Fly   581 PIGVDTAQSHKL-PAQIVIETHQSSSELAAENDKQLDLINSIVQDELLKSTLVEQPVVNADEDIP 644
            |:. |:...|.| |..:.|:..|.|:.|.||..|:..:.|..:.|:
Zfish   487 PLS-DSKSGHSLSPPAVGIKHRQRSATLGAERSKENQVFNRSLHDD------------------- 531

  Fly   645 KLVKMLESTAADLDPPPVSLPTNIFPAPEMQGVGNAAAADPNNIMDTANEDEITADFLQHVVGLI 709
                                                                  .|::.....|.
Zfish   532 ------------------------------------------------------RDWVAKETALK 542

  Fly   710 EEDKQFEAEVVKQVLASTEPGTLDAIVSMPTSIEPVDVPQVQAHTNLLPNASLTEPAQSMTSLPI 774
            |.::                                                |.|..|
Zfish   543 ERER------------------------------------------------LREKRQ------- 552

  Fly   775 ACSTPSRSVAASTPPTSAKVVRGYGRVIYLPPIEAPTTRAKRRAQFPSAPGMAATSSSDAGNLSF 839
                                 |.:.|      |:....:.|:|         .:.|.|.:...|.
Zfish   553 ---------------------REFFR------IKLKKKKKKKR---------KSKSDSHSTEESI 581

  Fly   840 GESSLDASINQ----PLNTSSLSNDSQPGSGPKRPNPREPSMARRSTAPRRSKKLDASQNNDPDA 900
            |...|..::|.    ||   ||::.|..|.||::               ..|:..|:|.:...|:
Zfish   582 GPKPLPCNLNSAHKLPL---SLTHRSYTGHGPEK---------------MLSQGEDSSSDLSSDS 628

  Fly   901 SESQEDDDDPNK--------------------LWCICRQPHNNRFMICCDLCEDWFHGTCVGVTK 945
            ....||:.|...                    :.|||.....|.|||.||.|..|.||||:|:
Zfish   629 PVWSEDESDTELDLNVPLSEQGVETVTHSSEIVRCICEVQEENDFMIQCDECLCWQHGTCMGL-- 691

  Fly   946 AMGTDMENKGIDWKCPKCVKRQEERSQPRITDMLVTRPTTQPEQRPSETKVLTTTAEIVQVAAPS 1010
                                  .|.|.|
Zfish   692 ----------------------YEDSVP------------------------------------- 697

  Fly  1011 APRRTLPVVLTVASSPMRIPMAKPAKKFPTGAISHQQQQQLNFIRLGPSPGKRISETLCVVCKRP 1075
                                                                  ....|.:|:.|
Zfish   698 ------------------------------------------------------DSYSCYICRDP 708

  Fly  1076 ASTSSVYCGEECIRKYAQSAIQAHAATKGPLPQNAG---AQSLLNNSFDAKKNKKKDLFEDVLRQ 1137
            .               ||...|.:...|..|  ::|   ..|.|..::..:.:||......:|..
Zfish   709 P---------------AQRQSQRYWYDKDWL--SSGHMYGLSFLEENYSHQNSKKVTAAHQLLGD 756

  Fly  1138 ADTVSKVERINVFERKSGRVITGHMAPSAH-QFRKWLQENPSFEVLPSGTVQSADAEKRLLKGAP 1201
            ...|.:|  :|..:.|...:.|     .|| ..:.|.|           ..:.||..:|.:.|..
Zfish   757 VHRVFEV--LNGLQLKMSILQT-----QAHPDLKLWRQ-----------PWKHADGLRRRMAGDS 803

  Fly  1202 EAATSTSEPAVLGVAKKPPEGPAKLSHPQNTTVQASHQLGISSVRPLAKKDKEKTTPTVQAPTPN 1266
                        |:|...|..|.::...:..|:::                        :||:|
Zfish   804 ------------GIATPLPPSPPEMGENEFETLKS------------------------EAPSP- 831

  Fly  1267 RIAAGKPEPVRIGIRRSLREQLLARIKEAQAAEENSGQPTTQWPTV-----------LEVDQFVK 1320
                       :....|.::..:       ::|....:|.|.:|.|           .|::..::
Zfish   832 -----------METHCSFQDSYI-------SSEHCYQKPRTYYPAVERRLVVETRGGSELEDSLR 878

  Fly  1321 NVE--LEMFNS-FGRDVG-AKYKAKYRSLMFNIKDRKNRTLF---EKICAKQVEPRQLVRMTPEQ 1378
            :.|  |||... :|..:. .::|...||....::.|..|.:.   ||.|..:::..:...:||:.
Zfish   879 STEDLLEMAEQRYGTQLDHDQHKLADRSFSKELESRMKRLVSAEQEKSCGVEIKEEEPDPVTPDP 943

  Fly  1379 LASQELA---KWR----------EEENRHQLDMIKKSELDLLACAQNY 1413
            ....:|.   :|:          ::|..|::|:|:: |||:|....:|
Zfish   944 KPDPDLVLHQQWQLNLLEHIEAVQDEVTHRMDLIER-ELDVLESWLDY 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pps	NP_001247075.1	TNG2	<827..965	CDD:227367	37/161 (23%)
		PHD_PHF3_like	914..963	CDD:277027	16/48 (33%)
		BRK	1142..1186	CDD:197800	8/44 (18%)
		TFIIS_M	1274..1396	CDD:284835	26/152 (17%)
		SPOC	1623..1729	CDD:285043
phf20b	XP_005162050.1	MBT	1..68	CDD:302657
		TUDOR	90..135	CDD:119391	6/24 (25%)
		PHD_PHF20	662..705	CDD:277104	20/157 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030