Protein Alignment pps and MBD-R2

DIOPT Version :9

• Sequence 1: NP_001247075.1
• Gene: pps / 41524
• FlyBaseID: FBgn0082831
• Length: 2018
• Species: Drosophila melanogaster
• Sequence 2: NP_731688.2
• Gene: MBD-R2 / 41498
• FlyBaseID: FBgn0038016
• Length: 1169
• Species: Drosophila melanogaster
• Alignment Length: 1484
• Identity: 285/1484 - (19%)
• Similarity: 486/1484 - (32%)
• Gaps: 476/1484 - (32%)

  Fly   603 SSSELAAENDKQLDLINSIVQDELLKSTLVEQPVVNADEDIPKLVKMLESTAADLD--------- 658
            |:|.|...|..   ..:|...|.::::..::...::.:..|.|.|.:.......||
  Fly    12 STSRLLEHNGV---TYHSFPLDPIIRAIWIKNSRISLERQITKSVLVCSRHFRRLDFNTIRNGKY 73

  Fly   659 -PPPVSLPTNIFPAPEM---------QGVGNAA----AADPNNIMDTANEDEITADFLQHVVGLI 709
             ..|...|| :||..:|         :.:.:|:    ...|.|...:.|:|.|.|...|.|..::
  Fly    74 LLKPRVFPT-VFPWGKMDTAEIEADQRALQHASVEGTTETPGNAQSSTNDDVIKATVDQIVAQIL 137

  Fly   710 EEDKQFEAEVVKQVLASTEPG----TLDAIVSMPTSIEPVDVPQVQAHTNLLPNASLTEPAQSMT 770
            .|..:.:|         ||.|    ..|.:.:.|.|.|..:            .|:..||:
  Fly   138 SESAERKA---------TEEGKTGKAADDVKNTPESGEDAN------------KAAAKEPS---- 177

  Fly   771 SLPIACSTPSRSVAASTPPTSAKVVRGYGRVIYLPPIEAPTTRAKRRAQFPSAPGMAATSSSDAG 835
                  .||   ||||:..|             :|                 |||.|::|
  Fly   178 ------GTP---VAASSEAT-------------VP-----------------APGSASSS----- 198

  Fly   836 NLSFGESSLDASINQPLNTSSLSNDSQPGSGPKRPNPREPSMARRSTA--------PRRSKKLDA 892
                         |.||          ||:.||..||...::..|..|        |.|..:::.
  Fly   199 -------------NSPL----------PGTPPKYSNPHNLTIGARLEALSVEGNWLPARIVEVNE 240

  Fly   893 SQNN-------------DPDASESQEDDDDPNKLWCI-----CRQPHNNRFMICCDLCED----W 935
            ::..             .|..|.|.::       |..     .||..:||.:...:|.|.    |
  Fly   241 TEQTLLVRFERNHKLKVSPSTSGSFQE-------WMAIKSERLRQRLSNRVLPVFELDEKCMARW 298

  Fly   936 -----FHGTCVGVTKAMGTDMENKGIDWKCPKCVKRQEERSQPRITDMLVTRPTTQPEQRPSETK 995
                 |.||   :.|.:|.|......|              ...:.::........|:|.|.
  Fly   299 SGPRKFPGT---IRKLLGNDTYEVLFD--------------DGYVKNVRAVHMNKMPKQLPP--- 343

  Fly   996 VLTTTAEIVQVAAPSAPRRTLPVVLTVASSPMRIPMAKPAKKFPTGAISHQQQQQLNFIRLGPSP 1060
                    ||||...|.:...||...|:|:|:      ..|:..||:             ||.|.
  Fly   344 --------VQVAEEGASKSPTPVGTPVSSAPV------APKRASTGS-------------LGGSS 381

  Fly  1061 GKRIS-ETLCVVCKRP------ASTSSVYCGEECIRKYAQSAIQAHAATKGPLPQNAGAQSLLNN 1118
            |...| ::.|...:|.      ||......|...|....:..  .|.....|:    |.:..|
  Fly   382 GSSGSKKSKCAPQRRDWPLLDMASLDIASLGLPEIPHDGEWT--CHWVNDQPI----GTEGFL-- 438

  Fly  1119 SFDAKKNKKKDLFEDVLRQADTVSKV-ERINVFERKSGRVITGHMAPSAHQFR-----KWLQENP 1177
             ...:..|...:.:|.......:..: :|.||.    |:.....::||..:||     |...|:.
  Fly   439 -IVGEHQKPTVIVQDWRLPPGWIKHMYQRSNVL----GKWDVILVSPSGKRFRSKSDLKLFLESQ 498

  Fly  1178 SFEVLPSGTVQSADAEKRLLKGAPEAATSTSEPAVLGVAKKPPEGPAKLSHPQNTTVQAS--HQL 1240
            :....|.  |......:|..|.. .|...|.     |...:||..|..:....|:|:..|  .|.
  Fly   499 NLVYNPD--VYDFSIHRRRAKDI-NAYVYTH-----GYNPQPPPKPRPMDVSMNSTLDQSITSQH 555

  Fly  1241 GISSVRPLAKKDKEKTTPTVQAPTPNRIAAGKPEPVRIGIRRSLREQLLARIKEAQAAEENSGQP 1305
            .:.|.....|:.:....|......|..:.:.:.:|.     ...:.::.|.|.|  |:|..:.|.
  Fly   556 SLPSTPMPVKESQYMEAPVASLMPPAELMSPQTQPA-----DETKPKIEAEILE--ASEGGTSQL 613

  Fly  1306 TTQWPTVLEVD-QFVKNVELEMFNSF---GRDVGAKYKAKYRSLMFNIKDRKNRTLFEKICAKQV 1366
            ....|.|:|.. .|:..:::::.::.   .|:..||...|...|:.:|:.      :.|..|:.|
  Fly   614 MLADPHVVENGFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFLLIHIRH------YHKEFAEHV 672

  Fly  1367 E--PRQLVRMTPEQLASQELA-KWREEENRHQLDMIKKSELDLLACAQNYVVKTH---------- 1418
            .  |:.           |||| |.....:..|::.:.|:::.    .|.:..|.|
  Fly   673 SHCPKM-----------QELAVKRTHPSSIDQVEAVPKNQIP----NQQFFAKMHQQDLQQSRSF 722

  Fly  1419 KGEEVIATKV-----DVTLPEENVS---EASSMADTKQTSLVSE-------PSTS---TLERSTS 1465
            |.:.|.||..     |:|..:..:|   |..|::.|.::.:..|       |:.|   :|.||..
  Fly   723 KRQSVSATATSSTPSDITPTKALLSPKMEPPSVSPTVESGIKQEDVSLDAGPTQSFNPSLSRSCK 787

  Fly  1466 REKAGSSKEKRHKSHKHHHRKRSRSRSNSRGRSVDKRHRRQHNEGGEQPGSGEREHRSREKQSRE 1530
            |.:...||            :.|.||.::|.|| .:|.....|..|         |...|:...|
  Fly   788 RARLSPSK------------RPSGSRKSNRQRS-QRRPILSDNPAG---------HGLTEQDVEE 830

  Fly  1531 RDEIVPSPLPKKRDENDQSPVPKKTAEKKTEASAYNLVDQILESEKTVEQAANLGKPKPSPKPLP 1595
            ..:...:|.|..|.::           ||..:.|.......::|....:..:.     ||.....
  Fly   831 TRQSFNTPTPDTRIDS-----------KKRRSGAATTPISSIDSPAMGDSVST-----PSSNDQT 879

  Fly  1596 TLPSSLKAPEPMDNYSR---YLHGLTTSSLWSGTL-KMIDLADFEIVMYPVQGNC-----HQLGN 1651
            .:.::| ||.|.:..|:   |:..       :|.| :::.:...||:      ||     .:.|.
  Fly   880 DINAAL-APPPAETLSKAPQYIKE-------NGELIRIVRMRQEEII------NCICEYGEEDGL 930

  Fly  1652 LMPSQMDVIGRITRVNVWEY-----IKKLKKSPTKEVVIVNIFPASPSETYKF----DLFFEYLD 1707
            ::..::.:        .|::     |.|....|.|.|..:...|....::.:|    |..||
  Fly   931 MIQCELCL--------CWQHGACNGIVKEADVPDKYVCYICRNPQRGRDSMRFKHDQDWLFE--- 984

  Fly  1708 SRQRLGVLGVDSDQIRDFYIFPLGSGDKLP-PALQTAEP--VPFYEEAQRPNTLLGIIVRCLSKR 1769
                                      .||| .|..||.|  ...:|..:|.:||.|.::.
  Fly   985 --------------------------GKLPVAAYHTANPQATKQFELLKRSHTLTGNLLD----- 1018

  Fly  1770 PADAVPSTPSVPTPVPALSSKVAKRSRSSISYPAQSSPKR---KISTHSTSSKDDEFDIDAIIKA 1831
                                  ||||..|:......:..|   |:  :..:.|.||.::|:....
  Fly  1019 ----------------------AKRSMHSLLVKINIARNRCHPKL--YLWAKKWDEDNLDSTALT 1059

  Fly  1832 PIAKLQKTAPKV--VPQPSVPNDADEPYSPGGSDDELVPSAP-------QRPNDLERQVNEINKQ 1887
            |:.:.:..||.:  ||||....|.:|      ....|:....       .|.||:|.:::|:.|:
  Fly  1060 PVKRAKLEAPDLPNVPQPEAAIDPEE------CQYRLIEHIKVQQSLVLDRLNDIEAEMDELEKE 1118

  Fly  1888 IAAQQMEIAGLLKVEPTGSASSSNVLAAISIPANLSKILASIKDKTNLPSSADD 1941
            .....::.|.:        :::...||.........|.||.:....|:..:..|
  Fly  1119 DTLDDLKDADI--------STTKEALATFIKELETMKRLAKLNQVANMKQTLRD 1164

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pps	NP_001247075.1	TNG2	<827..965	CDD:227367	33/172 (19%)
		PHD_PHF3_like	914..963	CDD:277027	15/62 (24%)
		BRK	1142..1186	CDD:197800	11/49 (22%)
		TFIIS_M	1274..1396	CDD:284835	26/128 (20%)
		SPOC	1623..1729	CDD:285043	18/120 (15%)
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206	15/77 (19%)
		TUDOR	292..329	CDD:119391	9/53 (17%)
		MeCP2_MBD	449..522	CDD:238690	15/79 (19%)
		PHD_SF	919..963	CDD:304600	9/51 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.030