DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pps and Kdm7a

DIOPT Version :9

Sequence 1:	NP_001247075.1	Gene:	pps / 41524	FlyBaseID:	FBgn0082831	Length:	2018	Species:	Drosophila melanogaster
Sequence 2:	NP_001028602.2	Gene:	Kdm7a / 338523	MGIID:	2443388	Length:	940	Species:	Mus musculus

Alignment Length:	1235	Identity:	221/1235 - (17%)
Similarity:	391/1235 - (31%)	Gaps:	452/1235 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   826 MAATSSSDAGNLSFGESSLDASINQPLNTSSLSNDSQPGSGPKRPNPREPSMARRSTAPRRSKKL 890
            ||..:::.|...:.|.::...|:            |.||               |::||
Mouse     1 MAGAAAAVAAGAAAGAAAAAGSV------------SAPG---------------RASAP------ 32

  Fly   891 DASQNNDPDASESQEDDDDPNKLWCICRQPHN-NRFMICCDLCEDWFHGTCVGVTKAMGTDMENK 954
                             ..|..::|:||||:: |||||.||:|:|||||:||||.:....|::.
Mouse    33 -----------------PPPPPVYCVCRQPYDVNRFMIECDVCKDWFHGSCVGVEEHHAVDIDL- 79

  Fly   955 GIDWKCPKC--------VKRQEERSQPRITDMLVTRPTTQPEQRPSETKVLTTTAEIVQVAAPSA 1011
               :.||.|        :|::....:...|::       ....:|.:........|:.....|||
Mouse    80 ---YHCPDCAALHGSSLMKKRRNWHRHDYTEV-------DDGSKPVQAGTRAFVKELRSRVFPSA 134

  Fly  1012 PRRTLPVVLTVASSPMR----------IPMAKPAKKFPTGAISHQQQQQLNFIRLGPSPGKRISE 1066
            ..    :::.:..|.:.          :|:..| |....|            :|| |||...:.:
Mouse   135 DE----IIVKMHGSQLTQRYLEKHGFDVPIMVP-KLDDLG------------LRL-PSPAFSVMD 181

  Fly  1067 TLCVVCKRPASTSSVYCGEECIRKYAQSAIQAHAATKGPLPQNAGAQSLLNNSFDAKKNKKKDLF 1131
                                 :.:|                  .|...::            |:.
Mouse   182 ---------------------VERY------------------VGGDKVI------------DVI 195

  Fly  1132 EDVLRQADTVSKVERINVFERKSGRVITGHMAPSAHQFRKWLQENPSFEVLPSGTVQSADAEKRL 1196
             ||.||||  ||:                    :.|.:.|:.......:||...:::.:|.:...
Mouse   196 -DVARQAD--SKM--------------------TLHNYVKYFMNPDRPKVLNVISLEFSDTKMSE 237

  Fly  1197 LKGAPEAATSTSEPAVLGVAKKPPEGPAKLSHPQNTTVQASHQLGISSVRPLAKKDKEKTTPTVQ 1261
            |...|:.|                   .|||..:|....       .||.|         .|.||
Mouse   238 LVEVPDIA-------------------RKLSWVENYWPD-------DSVFP---------KPFVQ 267

  Fly  1262 APTPNRIAAGKPEPVRIGIRRSLREQLLARIKEAQAAEENSGQPTTQWPTVL---EVDQFVK--N 1321
                                    :..|..::::..........|:.|..||   ::...:|  |
Mouse   268 ------------------------KYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTN 308

  Fly  1322 VELEMFNSFGRDV-------GAKYKAKYRSLMFNIKDRKNRTLFEKICAKQVEPRQLVRMTPEQL 1379
            ..|.::.|:...|       |.|....|:.::     ::..|||        .|...:...   |
Mouse   309 ENLALYESWSSSVTQSEVFFGDKVDKCYKCVV-----KQGHTLF--------VPTGWIHAV---L 357

  Fly  1380 ASQ-----------------ELAKWREEENRHQLDMIK------------KSELDLLA------- 1408
            .||                 :|..:..|:.....|:.|            ||.|:.|.
Mouse   358 TSQDCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAICWFVAKSLLETLKELKEDGF 422

  Fly  1409 CAQNYVVKTHKGEEVIATKVDVTLPEENVSE-ASSMAD-TKQTSLVSEPSTSTLERSTSREKAGS 1471
            ..|:|:|   :|.:.:.|.:.:.:.:|.||| |..:.| .:...|:.|  .|.:.|:...|....
Mouse   423 QPQSYLV---QGVKALHTALKLWMKKELVSEHAFEIPDNVRPGHLIKE--LSKVIRAIEEENGKP 482

  Fly  1472 ------------SKEKRHKSHKHHHRKRSRSRSNSRGRS-----VDKRHRRQHNEGGE------- 1512
                        |:.....|..:|.|::.|...:...|:     :.:.|.|:..:..|
Mouse   483 VKSQGIPSVCPVSRPSNEASPPYHSRRKMRKLRDHNVRTPSNLDILELHTREVLKRLEMCPWEED 547

  Fly  1513 --------------QPGSGEREHRSREKQSR-----------ERDEIVPSPLPKKRDENDQSPVP 1552
                          ||.|...|.|:::...|           ||.......|.....||::...|
Mouse   548 LLSSKLNGKFNKHLQPSSTVPEWRAKDNDLRLLLTNGRIIKDERQLFADRSLYTADSENEEDKKP 612

  Fly  1553 KKTAEKKTEASAYNLVDQILESEKTVEQAANLGKPKPSPKPLPTLPSSLKAPEPMDNYSRYLHG- 1616
            .:.|..|||.|:..            |:|.:.|.|||..:...::.|.|:: .|    |.|..|
Mouse   613 TQNANMKTEQSSGR------------EEAESQGSPKPLNRIFTSVRSELRS-RP----SEYSDGS 660

  Fly  1617 ----------------LTTSSLWSGTLKMIDLADFEIVMYPVQGNCHQLGNLMPSQMDVIGRITR 1665
                            .|..|..||..|.                 |::.:....:.|::..:
Mouse   661 DSEDSGPDCTALKINFATEDSESSGDEKK-----------------HEITSHFKEESDIVRNL-- 706

  Fly  1666 VNVWEYIKKLKKSPTKEVVIVNIFPASPS---ETYKFDLF---FEYLDSRQRLGVLGVDSDQIRD 1724
                  ::|.:|...:|:.:....|.|.|   |..:..|.   ..|....|| .:...|....::
Mouse   707 ------LQKSQKPSRQEIPVKRECPTSTSTEEEAIQGMLSMAGLHYSSCLQR-QIQSTDCSGEKN 764

  Fly  1725 FYIFPL---GSGDKLPPALQTAEPVPFYEEAQRPNTLLGIIVRCLSKRPADAVPSTPSVPTPVPA 1786
            ....|.   ||..:.....:..:||.|...|:..:.  .::....:|:    ...|........:
Mouse   765 SLQDPSSCHGSNPEFRQLYRCNKPVEFGYHAKTEDQ--DLMTSSWNKQ----FDRTSRFNAQDLS 823

  Fly  1787 LSSK-VAKRSRSSISYPAQSSPKRKISTHSTSSKDDEFDIDAIIKAPIAKLQKTAPKVVPQPSVP 1850
            .|.| :.|.|.|.|:..|||  :..:.::|:|.::.::.::              |.:| ...:.
Mouse   824 RSQKHIKKESSSEINQKAQS--RHCVDSNSSSIQNGKYTLN--------------PSLV-SCQIS 871

  Fly  1851 NDADEPYSPGGSDDELVPSAPQR-----PNDLERQVNE---INKQIAAQQMEIAGLLKVEPTGSA 1907
            |.:..|..|.|.....:|..|.:     |..:..|..:   ..|.:|..:..:..:||:...|.|
Mouse   872 NGSLSPERPIGETSFSMPLHPTKRPASNPPPISNQATKGKRPKKGMATAKQRLGKILKLNRNGHA 936

Fly 1908 1907
Mouse 937 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pps	NP_001247075.1	TNG2	<827..965	CDD:227367	37/146 (25%)
		PHD_PHF3_like	914..963	CDD:277027	25/49 (51%)
		BRK	1142..1186	CDD:197800	6/43 (14%)
		TFIIS_M	1274..1396	CDD:284835	22/150 (15%)
		SPOC	1623..1729	CDD:285043	17/111 (15%)
Kdm7a	NP_001028602.2	PHD_KDM7	39..88	CDD:277110	26/52 (50%)
		Linker. /evidence=ECO:0000250	97..114		1/23 (4%)
		JmjC	234..297	CDD:214721	18/121 (15%)
		cupin_like	269..369	CDD:304367	20/115 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	483..509		3/25 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	599..670		21/87 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	710..729		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..854		10/37 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	876..920		9/43 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1634
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900