DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pps and phf20l1

DIOPT Version :9

Sequence 1:	NP_001247075.1	Gene:	pps / 41524	FlyBaseID:	FBgn0082831	Length:	2018	Species:	Drosophila melanogaster
Sequence 2:	XP_009290756.1	Gene:	phf20l1 / 327626	ZFINID:	ZDB-GENE-030131-5837	Length:	1116	Species:	Danio rerio

Alignment Length:	947	Identity:	186/947 - (19%)
Similarity:	298/947 - (31%)	Gaps:	308/947 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 RRKPKERPQI--VGLRVEQFYADNTADMVVKNALKLAGVSVYKRTAETDALMEVIRNDHNYTPFT 209
            |.:|.|||.:  .||:.|: .::..::|......:|.|     .|..|:        |....|
Zfish    64 RLRPLERPALRKEGLKEEE-VSERLSEMRASRLRELPG-----STESTE--------DQKDLP-- 112

  Fly   210 SPEQLKNHKRDEKMAMEMQAQSRKIIMQAPGSVKLINAKKRVQAIPLSPVQVK-VQRLPVKPHQV 273
               |.:...||.:..:......|    ..|..::.|| |:....:......:: |:|:.:| ...
Zfish   113 ---QQRQELRDGEEVLARWTDCR----YYPAKIESIN-KEGTYTVQFYDGVIRCVKRIHIK-SMP 168

  Fly   274 QQAAQLQPKVQLIRKPIHSPLPRQK----PEIIANNSVNARLRPTRAPVKVIAPPVQEYIEDDDD 334
            :.|...|..:.|::..  |...:.|    |...||::.:...|..:.         .:..|||||
Zfish   169 EDAKGQQDWIALVKAA--SAAAKNKGGNRPRTSANSNKDREDRREQR---------SDEEEDDDD 222

  Fly   335 AQSSDSAEEENADKAYDSEEMSEESDEFQESDNDRDSDMD------------FDMRHSNRRNPN- 386
            |...|..::::     |.||..||.|...|...|.||:.:            ...|.|.|:...
Zfish   223 ADEDDDDDDDD-----DGEEEEEEEDSESEKLADLDSEEEDSKPPAEELESAIAKRRSKRQGNQC 282

  Fly   387 --KRKRVRK-------------VVRQTPSKPMKPLPPPPTTPQHFPELKKRKEVLEPKAPQIGQI 436
              ||.|:.|             ..::.|..|.:.:|.|..:|            .:.|:..:...
Zfish   283 SIKRSRLGKGAGCADTETELKAETKELPVTPQQKVPSPEPSP------------ADEKSQSVSAQ 335

  Fly   437 IQMPATKSVPAVFALGRGL--------PSTSFLKIRPTHQSLPVKRPPLP----TTPANSNVRRM 489
            ...|:..:.||..|..|.|        .|.......|....||.....||    |.|::|..||.
Zfish   336 KTTPSLSNPPACKARSRRLKHDSGESASSCQNTPAAPESSPLPSPTQTLPDSTHTAPSSSPQRRR 400

  Fly   490 PAVQLGRIVN-----SP-------------------QEVKEIIINKNMASPKGVFTNLNTLLGED 530
            .:.:|....:     ||                   .|....::.....|.|.|..:.:|.
Zfish   401 RSQRLATTSDLICPPSPHTRDTATHPTPPPDGPLIADEDSSTVVKTEAISQKPVSESPSTA---- 461

  Fly   531 NNAATKSSPVPLRHRAVMSPSTPRSSYNQQM----SPIVVPVPAQAHTPSKGFMPIGVDTAQSHK 591
              .:|.|:..|:..:..|:...|.   ||..    ||.|||...| ..||:        |.:::|
Zfish   462 --TSTASAQAPITEKEKMNDVLPS---NQAALEGNSPAVVPAAIQ-KVPSR--------TPKANK 512

  Fly   592 LPAQIVIETHQSSSELAAENDKQLDLIN-------SIVQDELLKSTLVEQPVVNADEDIPKLVKM 649
            ...:.:|.|.:|...| |.|:..:||.:       |.......|:.|::..           :|.
Zfish   513 HAREPIINTKRSDDPL-APNECIIDLDHNKFKCKVSGCSKAFRKAKLLDYH-----------LKY 565

  Fly   650 LESTAADLDPPPVSLPTNIFPAPEMQGVGNAAAADPNNIMDTANEDEITADFLQHVVGLIEEDKQ 714
            ..:|..::|....|        ||.:|...|.:|
Zfish   566 YHNTEKEMDTEVCS--------PEREGRTRATSA------------------------------- 591

  Fly   715 FEAEVVKQVLASTEPGTLDAIVSMPTSIEPVDVPQVQAHTNLLPNASLTEPAQSMTSLPIACSTP 779
                                  |||||... |||..:....:..::||:.....:......|..|
Zfish   592 ----------------------SMPTSTLS-DVPDNKRRRTVSTSSSLSSQGFMLQMDSGGCVRP 633

  Fly   780 SR-------SVAASTPPTSAKVVRGYGRVIYLPPIEAPTTRAKRRAQFPSAPGMAATSS-----S 832
            |:       |.:.|:..|.          :.|||........|...:.....|:...:.     .
Zfish   634 SKFCKKKRSSASMSSDSTE----------VSLPPPTFDNLHDKIIKKDKHLDGLCIKTERKFKLD 688

  Fly   833 DAGNLSFGESSLDA---------SINQ----------------PLNTSSLSNDSQPGSGPKRPNP 872
            |...|...:...|.         .|.|                .|:..||:...:|.|.|.|.:
Zfish   689 DKCQLFVKKRDKDRRDRKEKDLFRIKQKKKKKKKKKSKLHCYPDLDEMSLAYLERPSSPPHRSS- 752

  Fly   873 REPSMARRST--APRRSKKLDASQNN-------DPDASES---------------------QEDD 907
              .|..:.||  .||....:|.:..|       :...:||                     .|||
Zfish   753 --SSAFKHSTFQYPRAILSVDLTGENLSDIDFLEDSTTESLLFSGDEYNQDLDSITMEDFQDEDD 815

  Fly   908 DDPNKL-WCICRQPHNNRFMICCDLCEDWFHGTCVGV 943
            |..::: .|||.....|.|||.|:.|..|.|..|:|:
Zfish   816 DGADEIVRCICEMDEENGFMIQCEECMCWQHSVCMGL 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pps	NP_001247075.1	TNG2	<827..965	CDD:227367	38/178 (21%)
		PHD_PHF3_like	914..963	CDD:277027	13/30 (43%)
		BRK	1142..1186	CDD:197800
		TFIIS_M	1274..1396	CDD:284835
		SPOC	1623..1729	CDD:285043
phf20l1	XP_009290756.1	MBT	3..68	CDD:327428	1/3 (33%)
		TUDOR	121..165	CDD:119391	7/48 (15%)
		DUF3776	248..323	CDD:315317	14/74 (19%)
		Atrophin-1	<312..510	CDD:331285	46/227 (20%)
		PHD_PHF20L1	823..868	CDD:277103	13/30 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030