DRSC/TRiP Functional Genomics Resources

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Protein Alignment pps and SETD2

DIOPT Version :9

Sequence 1:NP_001247075.1 Gene:pps / 41524 FlyBaseID:FBgn0082831 Length:2018 Species:Drosophila melanogaster
Sequence 2:XP_011531934.1 Gene:SETD2 / 29072 HGNCID:18420 Length:2572 Species:Homo sapiens


Alignment Length:2438 Identity:425/2438 - (17%)
Similarity:702/2438 - (28%) Gaps:948/2438 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 PAAAEADSNLVVVYSKSGISFDERAIGNIMEEKSISTISVVRITSPTPSMVDQEEDERLEELANF 78
            |.:.|||:.             :..|.|.:||      .|.:|.:....:..::||..:      
Human   255 PESLEADTK-------------QDTISNSLEE------HVTQILNEQADISSKKEDSHI------ 294

  Fly    79 METATDSEL-DSDNGSQSGGDNASEMDEHDEENHNTGDDNNSDSTETEADAPRTRKRVGRKPKAI 142
               ..|.|: ||...|.|.....|:......|....|.:::.||..|.:.   .|....:...:|
Human   295 ---GKDEEIPDSSKISLSCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSS---QRSHDLKFSASI 353

  Fly   143 KKRKRRKPKERPQIVGLRVEQFYADNTADMVVKNALKLAGVSVYKRTAETDALMEVIRNDHNYTP 207
            :|.:..|....|                       ||...:....| ::||       .|..|..
Human   354 EKERDFKKSSAP-----------------------LKSEDLGKPSR-SKTD-------RDDKYFS 387

  Fly   208 FTSPEQ----LKNHKRDEKMAMEMQAQSRKIIMQAPGSVKLINAKKRVQAIPLSPVQVKVQRLPV 268
            ::..|:    :.:..|.|:.....::.||               .:|.....||..:.:      
Human   388 YSKLERDTRYVSSRCRSERERRRSRSHSR---------------SERGSRTNLSYSRSE------ 431

  Fly   269 KPHQVQQAAQLQPKVQLIRKPIHSPLPRQKPEIIANNSVNARLRPTRAPVKVIAPPVQEYIEDDD 333
            :.|......:..                             |..|.|...:...|     ..|:.
Human   432 RSHYYDSDRRYH-----------------------------RSSPYRERTRYSRP-----YTDNR 462

  Fly   334 DAQSSDSAEEENADKAYDSEEMSEESDEFQE------SDNDRDSDMDFDMRHSNRRNPNKRKRVR 392
            ..:||||  ||...|.| |...|..|..:::      |.:|||...:.......||.....|..|
Human   463 ARESSDS--EEEYKKTY-SRRTSSHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLER 524

  Fly   393 KVVRQTPSKPMKPLPPPP---------TTPQHFPELKKRKEVLEPKAPQIGQI------------ 436
            :..|.:.::.:|....||         :..:|.....:.|..|....|:..:.            
Human   525 ESKRTSENEAIKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEE 589

  Fly   437 --------IQMPATKSV--------PAVFALGRGLPSTSFLKIRPTHQ---SLPVKRPPLPTTPA 482
                    :|.|.:|..        |.....|...||.. |...||.:   .||:.:....|..:
Human   590 IKQSHSFSLQTPCSKGSELRMINKNPEREKAGSPAPSNR-LNDSPTLKKLDELPIFKSEFITHDS 653

  Fly   483 NSNVRRMPAVQLGRIVNSPQEVKEIIINKNMASPKGVFTNLNTLLGEDNNAATKSSPVPLRHRAV 547
            :.:::.:         :|..:||    |..:.|...:..|:|...|.:::.||..:.   :..||
Human   654 HDSIKEL---------DSLSKVK----NDQLRSFCPIELNINGSPGAESDLATFCTS---KTDAV 702

  Fly   548 MSPSTPRSSYNQQMSPIVVPVPAQAHTPSKGFMPIG-------VDTAQSHKLPAQIVIETHQSSS 605
            :..|.. |....::||:|    ......|.||..|.       .||...||          :|.|
Human   703 LMTSDD-SVTGSELSPLV----KACMLSSNGFQNISRCKEKDLDDTCMLHK----------KSES 752

  Fly   606 ELAAENDKQLDLINSIVQDELL---------KSTLVEQPV-------VNADEDI--------PKL 646
            ..     ::.:.:.|..||:|:         ..|:|::||       ...|.||        |.|
Human   753 PF-----RETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVDTRVSCCKTKDSDIYCTLNDSNPSL 812

  Fly   647 VKMLESTAADLDPPPVSLPTNIFPAPEMQGVGNAAAADPNNIMDTANEDEITADFLQHVVGLIEE 711
               ..|.|.:::|..:.:.:|.|....::  ......|..|:.|                     
Human   813 ---CNSEAENIEPSVMKISSNSFMNVHLE--SKPVICDSRNLTD--------------------- 851

  Fly   712 DKQFEAEVVKQVLASTEPGTLDAIVSMPTSIEPVDVPQVQAHTNLLPNASLTEPAQSMTSLPIAC 776
            ..:|..|..||.:.||...:::....:   .:|:....:               |.|:.|||...
Human   852 HSKFACEEYKQSIGSTSSASVNHFDDL---YQPIGSSGI---------------ASSLQSLPPGI 898

  Fly   777 STPSRSVAASTPPTSAKVVRGYGRVIYLPPIEAPTTRAKRRAQFPSAPG--MAATSSSDAGNLSF 839
            ...|.::......||              |:.....::|:.::|....|  ......||..:...
Human   899 KVDSLTLLKCGENTS--------------PVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGK 949

  Fly   840 GESSLDASINQPLNTSSLSNDSQPGSGPKRPNPREPSMARRSTAPRRSKKLDASQNNDPDASESQ 904
            |.:|.:...|..|:...|....:.|:               |..|.|..:.:.|.:...:.....
Human   950 GFASRENRRNNGLSGKCLQEAQEEGN---------------SILPERRGRPEISLDERGEGGHVH 999

  Fly   905 EDDDDPNKLWCICRQPHNNRFMICCDL---CEDWFHGTCVGVTKAMGTDMENKGIDWKCPKCVKR 966
            ..||             :......|||   .||     ..|||.|:..|...     ..|:.|..
Human  1000 TSDD-------------SEVVFSSCDLNLTMED-----SDGVTYALKCDSSG-----HAPEIVST 1041

  Fly   967 QEERSQPRITDMLVTRPTTQPEQRPSETKVLTTTAEIVQVAAPSAPRRTLPVVLTVASSPMRIPM 1031
            ..|       |...:..::..|....:|          .....|.||..|..|:.|..: ..:||
Human  1042 VHE-------DYSGSSESSNDESDSEDT----------DSDDSSIPRNRLQSVVVVPKN-STLPM 1088

  Fly  1032 AKPAKKFPTGAISHQQQQQLNFIRLGPSPGKRISETLCVVCKRPASTSSVYCGEECIRKYAQSAI 1096
            .:.:                                       |.|:.|    .:..|.|:    
Human  1089 EETS---------------------------------------PCSSRS----SQSYRHYS---- 1106

  Fly  1097 QAHAATKGPLPQNAGAQSLLNNSFDAKKNKKKDLFEDVLRQADTVSKVERINVFERKSGRVITGH 1161
                                ::..|.:...::.|:|:               .||.     |...
Human  1107 --------------------DHWEDERLESRRHLYEE---------------KFES-----IASK 1131

  Fly  1162 MAPSAHQF--RKWLQENPSFEVLPSGTVQSADAEKRLLKGAPEAATSTSEPAVLGVAKKPPEGPA 1224
            ..|...:|  .|..::||......|...|   .:.||                       ||   
Human  1132 ACPQTDKFFLHKGTEKNPEISFTQSSRKQ---IDNRL-----------------------PE--- 1167

  Fly  1225 KLSHPQNTTVQASHQLGISSVRPLAKKDKEKTTPTVQAPTPNRIAAGKPEPVRIGIRRSLREQLL 1289
             |||||:..|.::....:.| .||...:.|:   ||:|..|:|                .:|:|.
Human  1168 -LSHPQSDGVDSTSHTDVKS-DPLGHPNSEE---TVKAKIPSR----------------QQEELP 1211

  Fly  1290 ARIKEAQAAEENSGQPTT--QWPTVLEVDQFVKNVELEMFNS--FGRDVGAKYKAKYRSLMFNIK 1350
            ....:.:.....|.|.||  ..|     |..:...||...:|  .....|.....:.|:|.::..
Human  1212 IYSSDFEDVPNKSWQQTTFQNRP-----DSRLGKTELSFSSSCEIPHVDGLHSSEELRNLGWDFS 1271

  Fly  1351 DRKNRTLFEK------IC--------AKQV-------------EPR------------QLVRMTP 1376
            ..|..|.:::      .|        |:|.             :||            :.....|
Human  1272 QEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVYDRTQGQVP 1336

  Fly  1377 EQLAS--QELAKWREEENRHQLDMIKKSELDLLACAQNYVVKTHKGEEVIATKVDVTLPEENVSE 1439
            :.|..  :|...|.:::..|..|...|..|.|         :..||        .|..||  :|.
Human  1337 DSLTDDREEEENWDQQDGSHFSDQSDKFLLSL---------QKDKG--------SVQAPE--ISS 1382

  Fly  1440 ASSMADTKQTSLVSEPS--TSTLERSTSREKAGSSKEKRHKSHKHHHRKRSRSRSNSRGRSVDKR 1502
            .|    .|.|..|:|..  :..||::..::: |..|::         |:...|.|.|.|...|::
Human  1383 NS----IKDTLAVNEKKDFSKNLEKNDIKDR-GPLKKR---------RQEIESDSESDGELQDRK 1433

  Fly  1503 HRRQHNEGGE---QPGSG--------------ER-----------------------EHRSREKQ 1527
            ..|...|.||   .|||.              :|                       ..|.:.|.
Human  1434 KVRVEVEQGETSVPPGSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKS 1498

  Fly  1528 SRERDEIVPSPLPKKRDENDQSPV-------------------------PKKTAEKKTEASAYNL 1567
            .|:...:.....|..:||..|..:                         ..:..::|..|.    
Human  1499 HRDIKRMQCECTPLSKDERAQGEIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHAD---- 1559

  Fly  1568 VDQILESEKTVEQAANLGKPKPSPKPLPTLPSSLK-APEPMDN---------YSR------YLHG 1616
            |:.||..:|        |....:.|.||:....|: ..|.:|:         |:|      |...
Human  1560 VEVILTEKK--------GWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMA 1616

  Fly  1617 LTTSSLWSGTLKMIDLADFEIVMYPVQGNCHQLGN--------------------------LMPS 1655
            |....:...|.|               |||.:..|                          |:||
Human  1617 LKNDEIIDATQK---------------GNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPS 1666

  Fly  1656 QMDV--------------------------IGRITRVNVWEYIKKLKKSPTK---------EVVI 1685
            ..::                          :|...||::.....|:||..::         |.::
Human  1667 GSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSIRAAGGKMKKERSRKKDSVDGELEALM 1731

  Fly  1686 VN---------IFPASP------------------SETYKFDLFFEYLDSRQRLGVLGVDSDQIR 1723
            .|         :...|.                  ..|:.......:|: |..|.:|.:      
Human  1732 ENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLELIQNTHSQSCLKSFLE-RHGLSLLWI------ 1789

  Fly  1724 DFYIFPLGSGDKLPPALQ-----TAE--PVP---FYEEAQRPNTLLGIIVRCLSKRPADAVPSTP 1778
              ::..||.|.:....||     |.|  |:|   ..||::    :|.||.|....:         
Human  1790 --WMAELGDGRESNQKLQEEIIKTLEHLPIPTKNMLEESK----VLPIIQRWSQTK--------- 1839

  Fly  1779 SVPTPVPAL------SSKVAKRSRSSISYPAQSSPKRKISTHSTS-------------------- 1817
               |.||.|      ||:...|:.:.::.|   .|..|:||.:.:                    
Human  1840 ---TAVPPLSEGDGYSSENTSRAHTPLNTP---DPSTKLSTEADTDTPKKLMFRRLKIISENSMD 1898

  Fly  1818 -----------SKDDEFDIDAIIKAPI-----AKLQKTAPKVVPQPSVPNDAD-----EPYSPGG 1861
                       .||.:.|:|.:...|:     .:.|:..|:.:|:..|.::.:     .|.|...
Human  1899 SAISDATSELEGKDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETNIEASKLPTSEPE 1963

  Fly  1862 SDDELVPSAPQRPNDLERQVNEINKQIAAQQMEIAGLLKVEPTGSASSSNVLAAISIPANLSKIL 1926
            :|.|:.|. ......||..:||    ....|.|..|:..||...|....:....||..|  :|:|
Human  1964 ADAEIEPK-ESNGTKLEEPINE----ETPSQDEEEGVSDVESERSQEQPDKTVDISDLA--TKLL 2021

  Fly  1927 ASIKD------------------------------------KTNLPSSADDGDEE---------- 1945
            .|.||                                    ||...|...|.|::          
Human  2022 DSWKDLKEVYRIPKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNRSRERDPDKQTQNKEKRKRR 2086

  Fly  1946 --------------YNPEDDITATSSFASKKPRSKGRLAHLSEAELLSMVPDNLAGVIPRSSRTR 1996
                          ..|:|.....:|  .||.|.|.| ..||..|...:....:|   .|.::.:
Human  2087 SSLSPPSSAYERGTKRPDDRYDTPTS--KKKVRIKDR-NKLSTEERRKLFEQEVA---QREAQKQ 2145

  Fly  1997 HQLAQSPLTPTPLP--------PPPP----PPG 2017
            .|..|:....:|||        |..|    |||
Human  2146 QQQMQNLGMTSPLPYDSLGYNAPHHPFAGYPPG 2178

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppsNP_001247075.1 TNG2 <827..965 CDD:227367 25/140 (18%)
PHD_PHF3_like 914..963 CDD:277027 11/51 (22%)
BRK 1142..1186 CDD:197800 9/45 (20%)
TFIIS_M 1274..1396 CDD:284835 26/166 (16%)
SPOC 1623..1729 CDD:285043 23/193 (12%)
SETD2XP_011531934.1 AWS 1503..1557 CDD:197795 5/53 (9%)
SET 1558..1681 CDD:214614 25/149 (17%)
PostSET 1682..1698 CDD:214703 0/15 (0%)
Asp-B-Hydro_N <1948..2131 CDD:191249 39/192 (20%)
WW 2399..2428 CDD:278809
SRI 2477..2556 CDD:285448
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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