DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pps and cti6

DIOPT Version :9

Sequence 1:	NP_001247075.1	Gene:	pps / 41524	FlyBaseID:	FBgn0082831	Length:	2018	Species:	Drosophila melanogaster
Sequence 2:	NP_595212.1	Gene:	cti6 / 2539769	PomBaseID:	SPBC1685.08	Length:	424	Species:	Schizosaccharomyces pombe

Alignment Length:	582	Identity:	99/582 - (17%)
Similarity:	168/582 - (28%)	Gaps:	200/582 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   870 PNPREPSMARRSTAPRRSKKLDASQNNDPDASESQEDDDDPNKLW----CIC------RQPHNNR 924
            |:...|:...:.....:.:|......:.|:.|.|..::::.:...    |:|      .:..:..
pombe     2 PSNSTPANEEKEEESEKIQKSPVDTPHTPNGSVSDNEENETSSTGEVTRCVCGIVESDDEASDGG 66

  Fly   925 FMICCDLCEDWFHGTCVGVTKAMGTDMENKGIDWKCPKCVKRQEERSQPRITDMLVTRPTTQPEQ 989
            ..|.||.|..|.||.|||..                       :|...|.:....:..|...
pombe    67 LYIQCDQCSVWQHGNCVGFA-----------------------DESEVPEVYYCEICHPEFH--- 105

  Fly   990 RPSETKVLTTTAEIVQVAAPSAPRRTLPVVLTVASSPMRIPMAKPAKKFPTGAISHQQQQQLNFI 1054
                                                          |.:..|..:.|.:...|
pombe   106 ----------------------------------------------KVYQRGRGAKQSKYLGN-- 122

  Fly  1055 RLGPSPGKRISETLCVVCKRPASTSSVYCGEECIRKYAQSAIQAHAATKGPLPQNAGAQSLLNNS 1119
                  ||.|.                          |....::.:....|..:.:..|.|..||
pombe   123 ------GKPIE--------------------------ASQTEESSSTPPSPATKKSSKQRLTMNS 155

  Fly  1120 FDAKKNKKKDLFEDVLRQADTVSKVERINVFERKSGRVITGHMAPSAHQ----------FRKWLQ 1174
            .||..:     :|:.|..|...|.:.|     |..||..:..::|.|.|          .:|..:
pombe   156 RDAALD-----YEEYLAIAKEKSLIPR-----RSRGRTSSKSLSPPAPQDESQGTEINLKQKIEE 210

  Fly  1175 ENPSFEVL--------------PSGTVQSADAEKRLLKGAPEAATSTSEPAVLGVAK---KPPEG 1222
            ||.  |:|              .:.|...|:.:      |||..|..:...:....|   |...|
pombe   211 END--EILEDSKESKDENEENKETSTTNVAETD------APEEETVDTVEEIADEEKHSVKEESG 267

  Fly  1223 PAKLSHPQNTTVQASHQLGISSVRPLAKKDKEKTTPTVQAPTPNRIAAGKPEPVR-IGIRRSLRE 1286
            .|.....|.:|:.:     ||:.....:|.|.:.....:|..|..:|. ||...| :|.||.
pombe   268 EASPQSSQQSTITS-----ISTTTRSTRKAKREAAAEDKADLPAAVAP-KPSKTRKVGGRRG--- 323

  Fly  1287 QLLARIKEAQAAEENSGQPTTQWPTVLEVDQFVKNVELEMFNSFGRDVGAKYKAKYRSLMFNIKD 1351
                         ::|.....:.|.:.....||:.:             .|.|..:..:......
pombe   324 -------------KSSSNDNHRIPQLHPDGTFVETI-------------TKPKGLHSRITMTEMR 362

  Fly  1352 RKNRTLFEKICAKQVEPRQLVRMTPEQLASQELAKWREEENRHQLDMIKKSELDLLACAQNY 1413
            |:..::.|.|...|||   :...:....:|.:.:|...||.:..|.|:.....|||...|.:
pombe   363 RRVASMLEYIGHIQVE---MAAQSAGNQSSTKSSKEGPEEEKETLRMVDNLTRDLLHWEQRF 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pps	NP_001247075.1	TNG2	<827..965	CDD:227367	18/104 (17%)
		PHD_PHF3_like	914..963	CDD:277027	12/58 (21%)
		BRK	1142..1186	CDD:197800	13/67 (19%)
		TFIIS_M	1274..1396	CDD:284835	20/122 (16%)
		SPOC	1623..1729	CDD:285043
cti6	NP_595212.1	PHD_SF	50..100	CDD:304600	14/72 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030