DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pps and Setd2

DIOPT Version :9

Sequence 1:	NP_001247075.1	Gene:	pps / 41524	FlyBaseID:	FBgn0082831	Length:	2018	Species:	Drosophila melanogaster
Sequence 2:	XP_036010808.1	Gene:	Setd2 / 235626	MGIID:	1918177	Length:	2551	Species:	Mus musculus

Alignment Length:	2307	Identity:	425/2307 - (18%)
Similarity:	719/2307 - (31%)	Gaps:	755/2307 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ADSNLVVVYSKSGIS------FDERAIGNIMEEKSISTISVVR---ITSPTPSMVDQEED----- 69
            :|.:.:.:.||...|      |:...:|:..:|.|:.|.|..|   :.|.|  .:|:|.|
Mouse   308 SDGSKISLSSKKASSKKKSSQFEGTFLGSESDEDSVRTSSSQRSHDLKSST--SIDKERDFKKSS 370

  Fly    70 --ERLEELANFMETATD--------SELDSD----------------NGSQSGGDNASEMD---E 105
              .:.|:|.....:.|:        |:|:.|                :.|:|..|.||...   .
Mouse   371 APSKSEDLGKSSRSKTERDDRYCSYSKLERDTRYVSSRCRSERDRRRSRSRSRSDRASRTSLSYS 435

  Fly   106 HDEENHNTGDDNNSDST-----ETEADAPRTRKRVGRKPKAIKKRKRRKPKERP--QIVGLRVEQ 163
            ..|.:|....:.....:     .|....|.|..|......:..:.|:..|:...  ....||...
Mouse   436 RSERSHYYDSERRYHRSSPYRERTRYSRPYTDNRARESSDSEDEYKKTYPRRTSAHSYRDLRTSS 500

  Fly   164 FYADNTADMVVKNA-LKLAGVSVY--------KRTAETDALMEVI---------------RNDHN 204
            .|:....|...:.: |::.....|        |||:|.:.:....               ::|::
Mouse   501 SYSKFDRDCKTETSYLEMERRGKYTSKLERESKRTSEHETIKRCCSPPNELGFRRGSSYSKHDNS 565

  Fly   205 ---YTPFTSPEQLKNHKRDEKMAM----EMQAQSRKIIMQAPGS----VKLINAKKRVQAIPLSP 258
               |....|....||.|.......    |...||....:|.|.|    ::.||
Mouse   566 TSRYKSALSKSISKNDKFKNSFCCTELNEENKQSHSFSLQTPCSKGSELRTIN------------ 618

  Fly   259 VQVKVQRLPVKPHQVQQAAQLQPKVQLIRKPIHSPL---PRQKPEIIANNS------------VN 308
                      |..:.::.....|..||...|....|   |..|||.|.::.            .|
Mouse   619 ----------KISEREKTGSPTPSNQLNDSPTFKKLDESPVLKPEFIGHDGRESIKELELSKVKN 673

  Fly   309 ARLRP-TRAPVKVIAPP-----VQEYIEDDDDAQSSDSAEEENADKAYDSEEMSE-------ESD 360
            .:||. ....:.|...|     |..:.....||.|..|      |.:....|:|.       .|:
Mouse   674 DQLRNFCSIELNVNGSPETEADVATFCTSKTDAISMTS------DDSVTGSEVSPLIKACMLSSN 732

  Fly   361 EFQESDNDRDSDMDFDMRHSNRRNPNKRKRVRKVVRQTPSKPMKPLPPPPTTPQHFPELKKRKEV 425
            .||.....|:.|.|...|..|             ..::|.:.|:||..|     |..:|
Mouse   733 GFQNVGRCRERDSDDTCRQHN-------------TSKSPFREMEPLLSP-----HHDKL------ 773

  Fly   426 LEPKAPQIGQIIQMPATKSVPAVFALGRGLPSTSFLKIRPTHQSLPVKRPPLPTTPANSNVRRMP 490
                                                      .|||||....|.|.....|.:..
Mouse   774 ------------------------------------------MSLPVKTIDYPKTLIKEPVDKRH 796

  Fly   491 A---VQLGRIVNSPQEVKEIIINKNMASPKGVFTNLNTLLGEDNNAATKSSPVPLRHRAVMSPST 552
            :   .:...|..||.|..|    ...|.|..:..:.::.:    |...:|..|...:|    ..|
Mouse   797 SCCKTKDSDIYCSPNENPE----AENAEPSAMTISSHSFV----NVHLESKTVICDNR----EPT 849

  Fly   553 PRSSYN--QQMSPIVVPVPAQAHTPSKG-FMPI---GVDTAQSHKLPAQIVIETHQSSSELAAEN 611
            .|.|.|  .:....:....:.:|....| :.||   |:.:.||.  |:.|..|.:.|.:..|.|:
Mouse   850 DRHSENTCDEYKQSIGSTSSASHNHFDGLYEPIGSSGISSLQSP--PSGIRCEENTSPTLDAVES 912

  Fly   612 DKQLDLI--------------------------NSIVQDELLKSTLVE----------QPVVNAD 640
            .|.:|.:                          |:::..:.|:....|          :|.:..|
Mouse   913 KKGIDFLKYARKETDVGSALPDSGKGFSWENRHNNVLSGQSLQEAQEEGNSILHERRGRPEIPLD 977

  Fly   641 E---------DIPKLV--KMLESTAADLDPPPVSL--------PTNIFPAPEMQGVGNAAAADPN 686
            |         |..::|  ..|..|..|.|....:|        |..:....|.....:|:::|.:
Mouse   978 EEQRGHTHISDDSEVVFPYDLNLTMEDSDGITYTLKCDSSGNAPEIVSTVHEDYSGSSASSSDES 1042

  Fly   687 NIMDTANED-EITADFLQHVV---------------------------------GLIEEDKQFEA 717
            :..||.::| .|..:.||.||                                 ||......:|.
Mouse  1043 DSEDTESDDSSIPRNRLQSVVVVPKNSTLPMEETSPCSSRSSQSYKHYSDRWEDGLETRRHAYEE 1107

  Fly   718 EVVKQVLASTE-----PGTLDAIVSMPTSIEPVDVPQVQAHTNLLPNASLTEPAQSMTSLPIACS 777
            |...:..:.||     .||       ..|.|.......:...|.||:.:   .||| ..:.....
Mouse  1108 EYESKGCSQTEKYFLHKGT-------ERSAESCYSQFGRKADNHLPDIA---HAQS-DGVDSTSQ 1161

  Fly   778 TPSRS--VAASTPPTS--AKVVRGYGRVIYLPPIEAPTTRAKRRAQFPSAPGMAATSSSDAGNLS 838
            |.|||  :....|..:  ||..|.....:|....|....:::::..|.:.|..:....::   ||
Mouse  1162 TDSRSDHLGHLNPEDTLRAKTSRPQELPVYSDDFEDLPNKSRQQMIFSNRPDSSRLGKTE---LS 1223

  Fly   839 FGESSLDASINQPLNTS--------SLSNDSQPGSGPKRPNPR---------------------- 873
            | .||.|.|....|::|        ..|...:|.:..::|:..
Mouse  1224 F-SSSCDISRMDGLHSSEELRNLGWDFSQQERPTTTYQQPDSSYGTCGTHKYQQSTEHYGGTHNY 1287

  Fly   874 -------EPSMARRSTAPRRSKKLDASQNNDPDASESQEDDDDPNKLWCICRQPH----NNRFMI 927
                   :|..|.|  .|......|..|...||   |..||.:..:.|......|    :|:|
Mouse  1288 WQGNGYWDPRSAGR--PPGTGLAYDRIQGQVPD---SLTDDREEEEHWDQRSGSHFSSPSNKF-- 1345

  Fly   928 CCDLCEDWFHGTCVGVTKA-------------------MGTDMENKGIDWKCPKCVKRQEERSQP 973
                   :||....|..:|                   ...:.|...|..:.|...:|||..|..
Mouse  1346 -------FFHQKDKGSVQAPEISSNSIKDALVMNERKDFSKNFEKNDIKERGPPKKRRQELESDS 1403

  Fly   974 RITDMLVTRPTTQPEQRPSETKVLTTTAEIVQVAAPSAPRRTLPVVLTVASSPMRIPMAKPAKKF 1038
            .....|..|...:.|....|:.|    .:..::..||.           |....|.|
Mouse  1404 ESDGELQARKKVRVEMEQGESSV----PQHSELMGPSC-----------AMDDFRDP-------- 1445

  Fly  1039 PTGAISHQQQQQLNFIRLGPSPG-----------------------KRISETLCVVCKRPASTSS 1080
                     |:...|.:||..|.                       ||:......:.|...:...
Mouse  1446 ---------QRWKEFAKLGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGE 1501

  Fly  1081 VYCGEECI--------------------RKYAQSAIQAHAATKGPLPQNAG-----AQSLLNNSF 1120
            |.|||:|:                    |::.:   :.||..:..|.:..|     |:.|.:|:|
Mouse  1502 VACGEDCLNRLLMIECSSRCPNGDYCSNRRFQR---KQHADVEVILTEKKGWGLRAAKDLPSNTF 1563

  Fly  1121 ---------DAK----------KNKKKDLFEDVLRQADTVSKVERINVFERKSGRVITGHMAPSA 1166
                     |.|          :||....:...|:..:.:...::.|     ..|.:.....|:.
Mouse  1564 VLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGN-----CSRFMNHSCEPNC 1623

  Fly  1167 HQFRKWL---QENPSF---EVLPSGTVQSAD---------AEK--------------------RL 1196
             :.:||.   |....|   :::|||:..:.|         |:|                    |.
Mouse  1624 -ETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSIRA 1687

  Fly  1197 LKGAPEAATSTSEPAVLGVAKKPPEGPAKLSHP--------------------------QNTTVQ 1235
            ..|..:...|..:.:|.|..:...|....||..                          |||..|
Mouse  1688 AGGKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLKLIQNTHSQ 1752

  Fly  1236 A-------SHQLGISSV--------RPLAKKDKE---KTTPTVQAPTPNRIAAGKPEPVRIGIRR 1282
            :       .|.|.:..:        |...:|.:|   ||...:..||.|.:...|..|:   |:|
Mouse  1753 SCLKSFLERHGLSLLWIWMAELGDGRESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPI---IQR 1814

  Fly  1283 -SLREQLLARIKEAQA-AEEN-------------SGQPTTQWPTVLEVDQFVKNVELEMFNSFG- 1331
             |..:..:.::.|... :.||             |.:|:|:..|........:.:::...||..
Mouse  1815 WSQTKTAVPQLSEGDGYSSENTSRAHTPLNTPDPSAKPSTEMDTDTPKKLIFRRLKIISENSMDS 1879

  Fly  1332 --RDVGAKYKAKYRSLMFNIKDRKNRTLFEKICAKQVEPRQLVRMTPEQLASQELAKWREEENRH 1394
              .||.::.:.|        ..:::....|.:..::.|..|..::.|:||...::    |.|...
Mouse  1880 AVSDVTSELECK--------DGKEDLDQLETVTVEEDEELQSQQLLPQQLCESKV----ESEATI 1932

  Fly  1395 QLDMIKKSELDLLACAQNYVVKTHKGEEVIATKVDVTLPEENVSEASSMADTK---QTSLVSEPS 1456
            ::..:..||.:.....:.......|.||.||.:......||.||:..|....:   :|..:|:.:
Mouse  1933 EVSKLPTSEPEADTETEPKDSNGTKLEETIAEETPSQDEEEGVSDVESERSQEPPDKTVDISDLA 1997

  Fly  1457 TSTLE------------RSTSREKAGSSKEKRHKSHKHHHRKRSRSRSNSRGRSVDKRHRRQHNE 1509
            |..|:            :.:..||..:..|:...:.....:...::.:.||.|..||  :.|:.|
Mouse  1998 TKLLDSWKDLKEVYRIPKKSQTEKESTVAERGRDAAAFRDQTAPKTPNRSRERDPDK--QSQNKE 2060

  Fly  1510 GGEQPGSGEREHRSREKQSRERDEIVPSPLPKK----RDENDQSPVPKKTAEKKTEASAYNLVDQ 1570
            ..::.||......:.|:.::..|:...:|..||    :|.|..|     |.|::      .|.:|
Mouse  2061 KRKRRGSLSPPSSAYERGTKRPDDRYDTPTSKKKVRIKDRNKLS-----TEERR------KLFEQ 2114

  Fly  1571 IL---ESEKTVEQAANLGKPKPSP-------------------KPL-----PTLPSSLK------ 1602
            .:   |::|..:|..|||...|.|                   .|:     |:.|::.|
Mouse  2115 EVAQREAQKQQQQMQNLGMTSPLPFDSLGYNASHHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTP 2179

  Fly  1603 ------APEPMDNYSRYLHGLTTSSLWS-GTLKMID--LADFEI--VMYPVQGN--CHQLGN--L 1652
                  :|.|.| :::.|.|.:|.||.: .::.::.  .|..|:  ..|..|..  .||..|  :
Mouse  2180 SMDPVCSPAPYD-HAQPLVGHSTESLAAPPSVPVVPHVAASVEVSSSQYVAQNESVVHQDSNVPV 2243

  Fly  1653 MPSQMDVIGRITRVNVWEYIKKLKKSPTKEVVIVNIFPASPSETYKFDLFFEYLDSRQRLGVLGV 1717
            ||.|.....:....||||       |..:.|.:...:..:.|:|      ..|...:....|..|
Mouse  2244 MPVQAPGPVQGQNYNVWE-------SNQQSVSVQQQYSPAQSQT------TIYYQGQTCSTVYSV 2295

  Fly  1718 DSDQIRDFYIFPLGSGDKLPPALQT-AEPVPFYEEAQRPNTL--LGIIVRCLSKRPADAVPSTP- 1778
            .|..           ....||.:|: |:|...|.:.|:..|.  .|::|:..:...:...|..|
Mouse  2296 TSPY-----------SQTTPPIVQSYAQPSLQYIQGQQIFTAHPQGVVVQPTAAVTSIVAPGQPQ 2349

  Fly  1779 SVPTPVPALSSKVAKRSRSSISYPAQSSPKRK 1810
            |:..|...:::.:       :..|..|.||.|
Mouse  2350 SLQPPEMVVTNNL-------LDLPPPSPPKPK 2374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pps	NP_001247075.1	TNG2	<827..965	CDD:227367	34/197 (17%)
		PHD_PHF3_like	914..963	CDD:277027	11/71 (15%)
		BRK	1142..1186	CDD:197800	9/49 (18%)
		TFIIS_M	1274..1396	CDD:284835	24/139 (17%)
		SPOC	1623..1729	CDD:285043	22/114 (19%)
Setd2	XP_036010808.1	AWS	1483..1537	CDD:197795	9/56 (16%)
		SET_SETD2	1537..1678	CDD:380949	26/146 (18%)
		WW	2378..2407	CDD:395320
		SRI	2454..2542	CDD:400510
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030