DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pps and PHF3

DIOPT Version :9

Sequence 1:	NP_001247075.1	Gene:	pps / 41524	FlyBaseID:	FBgn0082831	Length:	2018	Species:	Drosophila melanogaster
Sequence 2:	XP_011533950.1	Gene:	PHF3 / 23469	HGNCID:	8921	Length:	2048	Species:	Homo sapiens

Alignment Length:	1873	Identity:	404/1873 - (21%)
Similarity:	663/1873 - (35%)	Gaps:	642/1873 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   423 KEVLEPKAPQIGQI---------------IQMPATKSVPAVFALGRGLPSTSFLKIRPTHQSLPV 472
            |.:|..|.|.:|..               .|||.:..|.....:..|:...|      .:.::..
Human    55 KNMLSDKDPMLGSASNQFCLPVLDSNDPNFQMPCSTVVGLDDIMDEGVVKES------GNDTIDE 113

  Fly   473 KRPPLPTTPANSNV--------RRMPAVQLGRIVNSPQEVKEIIINKNMASPKGVFTNLNTLLGE 529
            :...||.......|        |:.|.:.....|.|.::  ..|..::.|:|   .:|.....|:
Human   114 EELILPNRNLRDKVEENSVRSPRKSPRLMAQEQVRSLRQ--STIAKRSNAAP---LSNTKKASGK 173

  Fly   530 DNNAATKSSPVP----LRHRAVMS------PSTPRSSYNQQMSPIVVPVP-AQAHTPSKGFMPI- 582
            ..:.|......|    ::....||      ....|.|.|.....:|..|. :.:|:.....:.:
Human   174 TVSTAKAGVKQPERSQVKEEVCMSLKPEYHKENRRCSRNSGQIEVVPEVSVSSSHSSVSSCLEMK 238

  Fly   583 ---GVDTAQSHKLPAQIVIETHQSSSELAAE---------NDKQLDLINSIVQDELLK------- 628
               |:|:......|.:|.:.:|:.:..|.:|         |:..::.....|...|.|
Human   239 DEDGLDSKHKCNNPGEIDVPSHELNCSLLSETCVTIGEKKNEALMECKAKPVGSPLFKFSDKEEH 303

  Fly   629 -----------STLVEQPVV--NADEDIPKLVKM---------------LESTAADLDPPP---- 661
                       .|:||:.:.  ..::|..:.||:               :.|.||..:|..
Human   304 EQNDSISGKTGETVVEEMIATRKVEQDSKETVKLSHEDDHILEDAGSSDISSDAACTNPNKTENS 368

  Fly   662 -VSLPTNIFPAPEMQGVGNAAAADPNNIMD----TANEDEITADFLQHVVGLIEE---DKQFEA- 717
             |.||:.:....|.    |....|...|.|    |...::|      ..:|..|:   ::|.|:
Human   369 LVGLPSCVDEVTEC----NLELKDTMGIADKTENTLERNKI------EPLGYCEDAESNRQLEST 423

  Fly   718 -------EVVKQVLASTEPGTLD-AIVSMP------------TSIEPVDVPQVQAHTN------- 755
                   |||.......|...|: ||..:|            |.||..:...:|...|
Human   424 EFNKSNLEVVDTSTFGPESNILENAICDVPDQNSKQLNAIESTKIESHETANLQDDRNSQSSSVS 488

  Fly   756 LLPNASL----TEPA----QSMTSLPIACSTPSRSVAASTPPTSAKV---VRGYGRVIYLP---- 805
            .|.:.|:    |:|.    |:||:     ..|.:.|||......:|.   |:...|...:|
Human   489 YLESKSVKSKHTKPVIHSKQNMTT-----DAPKKIVAAKYEVIHSKTKVNVKSVKRNTDVPESQQ 548

  Fly   806 ----PIEAPTTRAKRRAQFPSAPGMAATSSSDAGNLSFGESSLDASIN--------QPLNTSSLS 858
                |::.      |:.|....|.:.:.:|......:...|.|..::.        :|| |.|||
Human   549 NFHRPVKV------RKKQIDKEPKIQSCNSGVKSVKNQAHSVLKKTLQDQTLVQIFKPL-THSLS 606

  Fly   859 NDS--QPG----------------SGPK---RPNPREPSMARRS--------------------- 881
            :.|  .||                |..|   :|..:.|:|...|
Human   607 DKSHAHPGCLKEPHHPAQTGHVSHSSQKQCHKPQQQAPAMKTNSHVKEELEHPGVEHFKEEDKLK 671

  Fly   882 ---------TAPRRSKK---LDASQNNDPD--ASESQEDDD-----------DPNKLWCICRQPH 921
                     ...|||.|   ||......||  |:..:|..|           .|:|....|::||
Human   672 LKKPEKNLQPRQRRSSKSFSLDEPPLFIPDNIATIRREGSDHSSSFESKYMWTPSKQCGFCKKPH 736

  Fly   922 NNRFMICCDLCEDWFHGTCVGVTKAMGTDMENKGIDWKCPKCVKRQEERSQPRITDMLVTRPTTQ 986
            .||||:.|..|:|||||.|||::.:....|..:..::.|.||...::::::       :..|.|.
Human   737 GNRFMVGCGRCDDWFHGDCVGLSLSQAQQMGEEDKEYVCVKCCAEEDKKTE-------ILDPDTL 794

  Fly   987 PEQRPSETKVLTTTAEIVQVAAPSAPRRTLPVVLTVASSPMRIPMAKPAKKFPTGAISHQQQQQL 1051
            ..|         .|.|.                                         |...:.:
Human   795 ENQ---------ATVEF-----------------------------------------HSGDKTM 809

  Fly  1052 NFIRLGPSPGKRISETLCVVCKRPASTSSVYCGEECIRKYAQSAIQAHAATKGPLPQNAGAQSLL 1116
            ...:||.|.......|                      ||..
Human   810 ECEKLGLSKHTTNDRT----------------------KYID----------------------- 829

  Fly  1117 NNSFDAKKNKKKDLFEDVLRQADTVSKVERINVFERKSGRVITGHMAPSA--HQFRKWLQENP-- 1177
                                  |||.  .::.:.:|:||.   |..:...  ::.:|| |..|
Human   830 ----------------------DTVK--HKVKILKRESGE---GRNSSDCRDNEIKKW-QLAPLR 866

  Fly  1178 --SFEVLPSGTVQSADAEKRLLKGAPEAATSTSEPAVLGVAKKPPEGPAKLSHPQNTTVQASHQL 1240
              ...|||.   :|::.:...:.......|.|.|.     |.||.      :|.:....:...:.
Human   867 KMGQPVLPR---RSSEEKSEKIPKESTTVTCTGEK-----ASKPG------THEKQEMKKKKVEK 917

  Fly  1241 GISSVRPLAKKDKEKTTPTVQAPTPNRIAAGKP--EPVRIGIRRSLREQLLARIKEA--QAAEEN 1301
            |:.:|.|.|                   :|.||  :.:|..:|.||::.|:.|:.::  :..||.
Human   918 GVLNVHPAA-------------------SASKPSADQIRQSVRHSLKDILMKRLTDSNLKVPEEK 963

  Fly  1302 SGQPTTQWPTVLEVDQFVKNVELEMFNSFGRDVGAKYKAKYRSLMFNIKDRKNRTLFEKICAKQV 1366
            :.:..|:             :|.|:| ||.||..||||.||||||||:||.||..||:|:...:|
Human   964 AAKVATK-------------IEKELF-SFFRDTDAKYKNKYRSLMFNLKDPKNNILFKKVLKGEV 1014

  Fly  1367 EPRQLVRMTPEQLASQELAKWREEENRHQLDMIKKSELDLLACAQNYVVK-THKGEEVIATKVDV 1430
            .|..|:||:||:|||:|||.||..||||.::||:|.:.::   .:..:.| |||||  |..:.|.
Human  1015 TPDHLIRMSPEELASKELAAWRRRENRHTIEMIEKEQREV---ERRPITKITHKGE--IEIESDA 1074

  Fly  1431 TLPEENVSEASSMADTKQTSLVSEPSTS-TLERSTSREKAGSSKEKRHKSHKHHHRKRSRSRSNS 1494
            .:.|:..:..           :.||:.: :||:     ..||.|:|.
Human  1075 PMKEQEAAME-----------IQEPAANKSLEK-----PEGSEKQKE------------------ 1105

  Fly  1495 RGRSVDKRHRRQHNEGGEQPGSGEREHRSREKQSRERDEI-----------VPSPLPKKRDENDQ 1548
                                   |.:..|::..|:.|..:           :..|:      :|.
Human  1106 -----------------------EVDSMSKDTTSQHRQHLFDLNCKICIGRMAPPV------DDL 1141

  Fly  1549 SP--------VPKKTAEKKTE--ASAYNLVDQILESEKTVEQAANLGKPKPSPKPLPTLPSSLKA 1603
            ||        |.:|.::.:.|  |.|.:....||.||...|:.....|...||.|.|.:|.:::.
Human  1142 SPKKVKVVVGVARKHSDNEAESIADALSSTSNILASEFFEEEKQESPKSTFSPAPRPEMPGTVEV 1206

  Fly  1604 PEPMDNYSRYLHGLTTSSLWSGTLKMIDLADFEIVMYPVQGNCHQLGNLMPSQMDVIGRITRVNV 1668
            .      |.:|..|  :.:|.|.:.|..:|.|....|||.|:...|...:|..:.|.|||:...|
Human  1207 E------STFLARL--NFIWKGFINMPSVAKFVTKAYPVSGSPEYLTEDLPDSIQVGGRISPQTV 1263

  Fly  1669 WEYIKKLKKSPTKEVVIVNIFPASPSETYKFDLFFEYLDSRQRLGVLGVDSDQIRDFYIFPLGSG 1733
            |:|::|:|.|.|||:.:|...|.:..:...:.|.|.|..||:|.||...:..|::|.|:.|||:.
Human  1264 WDYVEKIKASGTKEICVVRFTPVTEEDQISYTLLFAYFSSRKRYGVAANNMKQVKDMYLIPLGAT 1328

  Fly  1734 DKLPPALQTAEPVPFYE---EAQRPNTLLGIIVRCLSKRPADAVPSTPSV-PTPVPALSSKVAKR 1794
            ||:|..|     |||..   |..|||.|||:|:|...||...|..||..: .||          .
Human  1329 DKIPHPL-----VPFDGPGLELHRPNLLLGLIIRQKLKRQHSACASTSHIAETP----------E 1378

  Fly  1795 SRSSISYPAQSSPKRKISTHSTSSKDDEF---------------------DIDAIIKAPIAKLQK 1838
            |...|:.|.....|.::||.....::::|                     |:...:: |:.::.|
Human  1379 SAPPIALPPDKKSKIEVSTEEAPEEENDFFNSFTTVLHKQRNKPQQNLQEDLPTAVE-PLMEVTK 1442

  Fly  1839 TAP----KVVP--------QPSVPNDADEP-----------------YSPGGS--DDELVPSAP- 1871
            ..|    :.:|        ||:....|::|                 |....|  :...|...|
Human  1443 QEPPKPLRFLPGVLIGWENQPTTLELANKPLPVDDILQSLLGTTGQVYDQAQSVMEQNTVKEIPF 1507

  Fly  1872 ---QRPNDLERQVN-EI----NKQI------AAQQMEIAGLLKVEPTGSAS-SSNVLAAISI--- 1918
               |..:.:|:..| |:    ||:|      .::..:.:..::....||:| |:..|.::|:
Human  1508 LNEQTNSKIEKTDNVEVTDGENKEIKVKVDNISESTDKSAEIETSVVGSSSISAGSLTSLSLRGK 1572

  Fly  1919 PANLS--KILASI------------KDKTNLPSSADDGDEEYNPEDDITATSS 1957
            |.::|  ..|.::            |:|| |.....: |:|.|.:|:.|:.||
Human  1573 PPDVSTEAFLTNLSIQSKQEETVESKEKT-LKRQLQE-DQENNLQDNQTSNSS 1623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pps	NP_001247075.1	TNG2	<827..965	CDD:227367	52/212 (25%)
		PHD_PHF3_like	914..963	CDD:277027	19/48 (40%)
		BRK	1142..1186	CDD:197800	11/49 (22%)
		TFIIS_M	1274..1396	CDD:284835	54/123 (44%)
		SPOC	1623..1729	CDD:285043	37/105 (35%)
PHF3	XP_011533950.1	PHD_PHF3	728..778	CDD:277108	19/49 (39%)
		TFIIS_M	934..1044	CDD:284835	54/123 (44%)
		SPOC	1218..1324	CDD:285043	37/105 (35%)
		PRP38_assoc	<1941..2035	CDD:289628
		DUF1777	1954..>2048	CDD:285811
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I6514
eggNOG	1	0.900	-	-		E1_KOG1634
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41808
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11477
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6674
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.960