DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pps and Nsd3

DIOPT Version :9

Sequence 1:	NP_001247075.1	Gene:	pps / 41524	FlyBaseID:	FBgn0082831	Length:	2018	Species:	Drosophila melanogaster
Sequence 2:	NP_001074738.1	Gene:	Nsd3 / 234135	MGIID:	2142581	Length:	1446	Species:	Mus musculus

Alignment Length:	1279	Identity:	238/1279 - (18%)
Similarity:	409/1279 - (31%)	Gaps:	356/1279 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 KERPQIV---GLRVEQFYADNTADMVVKNALKLAGVSVYKRTAETDALMEVIRNDHNYTPFTSP- 211
            ::.||::   .:|.|..: ||.:|:|     :..|.:.::.|         ::....|.|.|..
Mouse    17 QQPPQLIDSANIRQEDAF-DNHSDIV-----EDGGPTPFEAT---------LQQGFQYPPTTEDL 66

  Fly   212 EQLKNHKRDEKMAMEMQAQSRKIIMQAPGSVKLINAKKRVQAIPLSPVQVKVQRLP-VKPHQV-Q 274
            ..|.|.........|.|.:.........||.....|.:.     .||.......:| .:||:: :
Mouse    67 PPLTNGYPPSISLYETQTKYPPYNQYPNGSANGFGAVRN-----FSPTDYYHSEIPNTRPHEILE 126

  Fly   275 QAAQLQPKVQLIRKPIHSPLPRQKPEIIANNSVNARLRPTRAPVKVI-----APPVQEYIEDDDD 334
            :.:..||      .|:..|.|...|             |...|..||     :|.::..|
Mouse   127 KPSPPQP------PPLPPPPPPPPP-------------PPSVPQTVIPKKTGSPEIKLKI----- 167

  Fly   335 AQSSDSAEEENADKAYDSEEMSEESDEFQESDNDRDSDMDFDMRHSNRRNPNKR----------- 388
                 :...:|..:.::|....:..:|.|.|::.:.       :|.:|:...|:
Mouse   168 -----TKTIQNGRELFESSLCGDLLNEVQASEHTKS-------KHESRKEKRKKSNRHESSRSEE 220

  Fly   389 KRVRKVVRQTPSKPMKPLPPPPTTPQHFPELKKRKE-VLEPKAPQIGQIIQMPATKSVPAV-FAL 451
            :|..|:.:..|....:|.....|.|:     |.|:| ||:...|....:..:|.|::...| |.:
Mouse   221 RRSHKIPKLEPEGQNRPNERVDTAPE-----KPREEPVLKEAIPVQPILSSVPTTETSTGVKFQV 280

  Fly   452 GRGLPSTSFLKIRPTHQSLP--VKRPPLPTTPANSNVRRMPAVQLGRIVNSPQEVKEIIINKNMA 514
            |    ...:.|: .|:...|  |...|.....:..|.|......:....|.|:  :..:..|.:.
Mouse   281 G----DLVWSKV-GTYPWWPCMVSSDPQLEVHSKINTRGAREYHVQFFSNQPE--RAWVHEKRVR 338

  Fly   515 SPKGVFTNLNTLLGEDNNAATKSS-------PVPLRHRAVMSPSTPRSSYNQQMSPIVVPVPAQA 572
            ..|| ......||.|....|:..|       |.|.|.||...
Mouse   339 EYKG-HEQYEELLAEAAKQASNHSEKQKIRKPRPQRERAQWD----------------------- 379

  Fly   573 HTPSKGFMPIGVDTAQ-SHKLPAQIVIETH------QSSSELAAENDKQLDLINSIVQDELLKST 630
                     ||:..|: :.|:..:..:|.:      :...|.:::..|.:.....:.:....:|.
Mouse   380 ---------IGIAHAEKALKMTREERVEQYTFIYIDKQPEEASSQAKKNVTSKTEVKKPRRPRSV 435

  Fly   631 LVEQP-VVNADE--------DIPKLVKMLESTAADLDPPPVSLPTNIFPAPEMQGVGNAAAADPN 686
            |..|| ..||.|        |:.:..:...::..:.:||||.:            ....|||
Mouse   436 LNSQPEQTNAGEVASSQSSTDLRRQSQRRHTSLEEEEPPPVKI------------AWKTAAA--- 485

  Fly   687 NIMDTANEDEITADFLQHVVGLIEEDKQFEAEVVK--QVLA---STEPGT-LDAIVSMPTSIEPV 745
                   ...:.|....| .|.::..|...:.|||  ||.|   :|..|. :|..|.....|...
Mouse   486 -------RKSLPASITMH-KGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNK 542

  Fly   746 DVPQVQAHTNLL---PNASLTEPAQSMTSL--------PIACSTPSRSV-AASTPPTSAKVVRGY 798
            ....|:....|:   |:....:||||.:|.        |:......||: ..|....||:||
Mouse   543 TEISVRGQDRLIISSPSQRSEKPAQSASSPEATSGSAGPVEKKQQRRSIRTRSESEKSAEVV--- 604

  Fly   799 GRVIYLPPIEAPTTRAKRRAQFPSAPGMAATSSSDAGNLSFGESSLDASINQPLNTSSLSNDSQP 863
                       |..:.|:. |..:||     .:|....|..|.|.:..|.......|..|.|.:.
Mouse   605 -----------PKKKIKKE-QVETAP-----QASLKTGLQKGASEISDSCKPLKKRSRASTDVET 652

  Fly   864 GSGPKRPNPREPSMARRSTAPRRSKKLDA-SQNNDPDASESQEDDDD-------PNKLWCICR-- 918
            .|...|......|...........|::|: |...|.|||::|..|..       .:|...:|:
Mouse   653 ASCTYRDTSDSDSRGLSDGQVGFGKQVDSPSATADADASDAQSVDSSLSRRGVGTSKKDTVCQVC 717

  Fly   919 QPHNNRFMICCDLCEDWFHGTCVGVTKAMGTDMENKGIDWKCPKCVKRQEERSQPRITDMLVTRP 983
            :...:..:.|...|...||..|:|:|..      .:| .:.|.:|...|......:::...|.|.
Mouse   718 EKAGDCLVACEGECCRHFHVECLGLTAV------PEG-HFTCEECETGQHPCFSCKVSGKDVKRC 775

  Fly   984 TTQPEQRPSETKVLTTTAEIVQVAAPSAPRRTLPVVLTVASSPMRIPMAKPAKKFPTGAISHQQQ 1048
            :            ::...:....|.                          .:||||....
Mouse   776 S------------VSVCGKFYHEAC--------------------------VRKFPTAIFE---- 798

  Fly  1049 QQLNFIRLGPSPGKRISETLCVVCKRPASTSSVYCGE--ECIRKYAQSAIQAHAATKGPLPQNAG 1111
                      |.|.|..:..|..|...........|.  .|:|    ..:..|.   |.....||
Mouse   799 ----------SKGFRCPQHCCSSCSMEKDIHKASKGRMMRCLR----CPVAYHV---GDACVAAG 846

  Fly  1112 AQSLLNNSFDAKKNKKKDLFEDVLRQADTVSKVERINV---FERKSGRVITGHMAPS----AHQF 1169
            :.|:.::......:.|:.            |:...|||   |....|.::..|..|.    |::.
Mouse   847 SVSVSSHILICSNHSKRS------------SQSAAINVGFCFVCARGLIVQDHSDPMFSSYAYKS 899

  Fly  1170 RKWLQENPSFEVLPSGTVQSADA-EKRLLKGAP----EAATSTSEPAVLGVAKKPPEG------- 1222
            ...|.|:...|::....:.|:.| :||..||..    |:..::..|..|.:  ..|||
Mouse   900 HYLLSESNRAELMKLPMIPSSSASKKRCEKGGRLLCCESCPASFHPECLSI--DMPEGCWNCNDC 962

  Fly  1223 ----------------------PAKLSHPQNTTVQ---ASHQLGISSVRPLAKKD-----KEKTT 1257
                                  ||::..|::..:.   ..|.||...|......|     :.:..
Mouse   963 KAGKKLHYKQIVWVKLGNYRWWPAEICSPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVF 1027

  Fly  1258 PTVQAPTPNRIAAGKPEPVRIGIRRSLREQLLARIKEAQAAEEN 1301
            |.|:.  ....|.|:.. :....:::| |:...|.:|.:|..|:
Mouse  1028 PYVEG--DKHFAEGQTS-INKTFKKAL-EEAAKRFQELKAQRES 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pps	NP_001247075.1	TNG2	<827..965	CDD:227367	32/147 (22%)
		PHD_PHF3_like	914..963	CDD:277027	10/50 (20%)
		BRK	1142..1186	CDD:197800	12/50 (24%)
		TFIIS_M	1274..1396	CDD:284835	6/28 (21%)
		SPOC	1623..1729	CDD:285043
Nsd3	NP_001074738.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..257		16/77 (21%)
		MSH6_like	277..393	CDD:99898	28/155 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..377		6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..476		12/64 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	550..705		40/174 (23%)
		PHD_SF	713..755	CDD:304600	10/48 (21%)
		PHD2_NSD3	761..807	CDD:277122	10/97 (10%)
		PHD_SF	808..860	CDD:304600	10/58 (17%)
		PHD4_NSD3	927..962	CDD:277128	8/36 (22%)
		WHSC1_related	968..1061	CDD:99899	15/96 (16%)
		AWS	1104..1154	CDD:197795
		SET	1155..1278	CDD:214614
		PHD5_NSD3	1332..1374	CDD:277131
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030