DRSC/TRiP Functional Genomics Resources

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Protein Alignment pps and Setd1a

DIOPT Version :9

Sequence 1:NP_001247075.1 Gene:pps / 41524 FlyBaseID:FBgn0082831 Length:2018 Species:Drosophila melanogaster
Sequence 2:NP_821172.2 Gene:Setd1a / 233904 MGIID:2446244 Length:1716 Species:Mus musculus


Alignment Length:1476 Identity:280/1476 - (18%)
Similarity:426/1476 - (28%) Gaps:597/1476 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   760 ASLTEPAQSMTSLPIACSTPSRSVAASTPPTSAKVVRG----YGRVIYLPPIEAPTTRAKRRAQF 820
            |:.|....:.|:...:.|:.|.|.::|:..:||...||    |      |.......|.:|...:
Mouse   324 ATATSATAAATAASSSSSSSSSSSSSSSSSSSASQFRGSDSSY------PAYYESWNRYQRHTSY 382

  Fly   821 PSAPGMAATSSSDAGNLSFGES-------------------SLDASINQPLNTSSLSNDSQPGSG 866
            |  |..|  :..|....||.|:                   |.|.....|.:.:......:||.|
Mouse   383 P--PRRA--TREDPSGASFAENTAERFPPSYTSYLAPEPNRSTDQDYRPPASEAPPPEPPEPGGG 443

  Fly   867 --------------------PKRPNPREPSMARRSTAPRRSKKLDASQNND--PDASESQEDDDD 909
                                |:|...|.|.   |..:|.||........|:  |.|..|..|   
Mouse   444 GGGSGGGGGGGGGGGGGAPSPEREEARTPP---RPASPARSGSPAPETTNESVPFAQHSSLD--- 502

  Fly   910 PNKLWCICRQPHNNRFMICCDLCED--------------------WFHGTC------VGVTKAMG 948
             :::..:.::..:....:..|..|:                    ..||.|      ........
Mouse   503 -SRIEMLLKEQRSKFSFLASDTEEEEENSSAGPGARDAGAEVPSGAGHGPCTPPPAPANFEDVAP 566

  Fly   949 TDMENKGIDWKCPKCVKRQEERSQPRITDMLVT--------RPTTQPEQRPSETKVLTTTAEIVQ 1005
            |.....|...:.||...:.:........||.::        .|...|.|:|              
Mouse   567 TGSGEPGAARESPKANGQNQASPCSSGEDMEISDDDRGGSPPPAPTPPQQP-------------- 617

  Fly  1006 VAAPSAPRRTLPVVLTVASSPMRIPMAKPAKKFP------------------------------- 1039
              .|..|....|....:||.|:..|..:||...|                               
Mouse   618 --PPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPPPHIYDFVNSLEL 680

  Fly  1040 ---TGA------ISHQQQQQ----LNFIRLGPS--------PGKRISETLCVVCKRPASTSSVY- 1082
               .||      :|.|.|.|    |:.:|.|..        ||....|.....   |....:.| 
Mouse   681 MDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLTAASAGPPGGAFGEAFLPF---PPPQEAAYG 742

  Fly  1083 -------CGEECIRKYAQSAIQAHAATKG-PLPQN--AGAQSLLNNSFDAKKNKKKDLFEDVLRQ 1137
                   .|:|....|::.|......... |||.:  :|.::.|.:..:|:..:.|     ||..
Mouse   743 LPYALYTQGQEGRGSYSREAYHLPLPMAAEPLPSSSVSGEEARLPHREEAEIAESK-----VLPS 802

  Fly  1138 ADTVSKV------ERINVFERKSGRVITGHMAPSAHQFRKWLQENPS----FEVLPSGTVQSADA 1192
            |.||.:|      |..::.:|...|.:..::|..|  |.:|.:....    |:.......:..|.
Mouse   803 AGTVGRVLATLVQEMKSIMQRDLNRKMVENVAFGA--FDQWWESKEEKAKPFQNAAKQQAKEEDK 865

  Fly  1193 EKRLLKGAPEAATSTSEPAVLGVAKKPPEGPAKLSHPQNTTVQASHQLGISSVRPLAKKDKEKTT 1257
            ||..||          ||.:|.:......|                  ||:.:...|        
Mouse   866 EKMKLK----------EPGMLSLVDWAKSG------------------GITGIEAFA-------- 894

  Fly  1258 PTVQAPTPNRIAAGKPEPVRIGIRRSLR-EQLLARIKE----AQAAEENSGQPTTQWPTVLEVDQ 1317
                              ...|:|.:|| .....:.||    ::|:||...:|:|.    .|.|:
Mouse   895 ------------------FGSGLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTP----AEEDE 937

  Fly  1318 FVKNVELEMFNSFGRDVGAK------YKAKYRSLMFNIKDRKNRTLFEKICAKQVEPRQLVRMTP 1376
            .....|.|. ...||. |.|      .:.|.:.     |.||:.||..:                
Mouse   938 DDPEREKEA-GEPGRP-GTKPPKRDEERGKTQG-----KHRKSFTLDSE---------------- 979

  Fly  1377 EQLASQELAKWREEENRHQLDMIKKSELDLLACAQNYVVKTHKGEEVIATK--VDVTLPEENVSE 1439
            .:.||||.:..::|::..:.:..::.|                 |.|.|||  .:.:..|:..|:
Mouse   980 GEEASQESSSEKDEDDDDEDEEDEEQE-----------------EAVDATKKEAEASDGEDEDSD 1027

  Fly  1440 ASSMADTKQTSLVSEPSTSTLERSTSREKAGSSKEKRHKSHKHHHRKRSRSRSNSRGRSVDKRHR 1504
            :||     |.||.::....  ..|||..::|||......|        |.|.|:|...|      
Mouse  1028 SSS-----QCSLYADSDGE--NGSTSDSESGSSSSSSSSS--------SSSSSSSSSES------ 1071

  Fly  1505 RQHNEGGEQPGSGEREHRSREKQSRERDEIVPSPL--PKKRDEND---QSPV----PKKTAEKKT 1560
                       |.|.|.:|....|......||.||  |.::.|.|   .|||    .|:|...:.
Mouse  1072 -----------SSEEEEQSAVIPSASPPREVPEPLPAPDEKPETDGLVDSPVMPLSEKETLPTQP 1125

  Fly  1561 EASAYNLVDQILESEKTVEQ---AANLGKPKPSPK-------PLPTLPSSLK------------- 1602
            ...|.       |...:|.|   ....|.|..:|:       |:|.||...|             
Mouse  1126 AGPAE-------EPPPSVPQPPAEPPAGPPDAAPRLDERPSSPIPLLPPPKKRRKTVSFSAAEEA 1183

  Fly  1603 -APEPMDNYSRYLHGLTTSSLWSGTLKMIDLADFEIVMYPVQGNCHQLGNLMPSQMDVIGRITRV 1666
             .|||           :|::                   |:|..         |...|..::.||
Mouse  1184 PVPEP-----------STAA-------------------PLQAK---------SSGPVSRKVPRV 1209

  Fly  1667 NVWEYIKKLKKSPTKEVVIVNIFPASPSETYKFDLFFEYLDSRQRLGVLG--------------- 1716
             |...|:.|   |.....:|..:|...:.           ..|.|.|  |               
Mouse  1210 -VERTIRNL---PLDHASLVKSWPEEVAR-----------GGRNRAG--GRVRSTEEEEATESGT 1257

  Fly  1717 -VDSDQIRDFYIFPLGSGDKLPPALQTAEPVPFYEEAQRPNTLLGIIVRCLSKRPADAVPSTPSV 1780
             ||...:.|..:.|...|....|....:|.....:||:||:.||..|:  |....|.|:...|:.
Mouse  1258 EVDLAVLADLALTPARRGLATLPTGDDSEATETSDEAERPSPLLSHIL--LEHNYALAIKPPPTT 1320

  Fly  1781 PT-----PVPALSSKVAKRSRSSISYPAQSSPKRKISTHSTSSKDDEFDIDAIIKAPIAKLQKTA 1840
            |.     |.|||::..             |||                 .|.:::||        
Mouse  1321 PAPRPLEPAPALAALF-------------SSP-----------------ADEVLEAP-------- 1347

  Fly  1841 PKVVPQPSVPNDADEPYSPGGSDDELVPSAPQRPNDLERQVNEINKQIAAQQMEIAGLLKVEPTG 1905
                  ..|..:|:||                            .:|:..|..|           
Mouse  1348 ------EVVVAEAEEP----------------------------KQQLQQQHPE----------- 1367

  Fly  1906 SASSSNVLAAISIPANLSKILASIKDKTNLPSSADDGDEEYNPEDDITATSSFASKKPRSKGRLA 1970
                                              .:|:||...|::.:.:|..:|...       
Mouse  1368 ----------------------------------QEGEEEEEDEEEESESSESSSSSS------- 1391

  Fly  1971 HLSEAELLSMVPDNLAGVIPRSSRTRHQLAQSPLTPTPLPPPPPPP 2016
              |:.|          |.|.|.|...|...:.|    |||||||||
Mouse  1392 --SDEE----------GAIRRRSLRSHTRRRRP----PLPPPPPPP 1421

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppsNP_001247075.1 TNG2 <827..965 CDD:227367 33/204 (16%)
PHD_PHF3_like 914..963 CDD:277027 8/74 (11%)
BRK 1142..1186 CDD:197800 9/53 (17%)
TFIIS_M 1274..1396 CDD:284835 30/132 (23%)
SPOC 1623..1729 CDD:285043 19/121 (16%)
Setd1aNP_821172.2 RRM_Set1A 92..186 CDD:240992
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 194..367 12/48 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..499 24/125 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 516..670 25/169 (15%)
Topoisomer_IB_N <835..>883 CDD:322080 12/59 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 849..869 4/19 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 911..1206 88/416 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1230..1259 4/41 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1275..1297 5/21 (24%)
HCFC1-binding motif (HBM). /evidence=ECO:0000250|UniProtKB:O15047 1307..1311 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1355..1427 28/163 (17%)
Interaction with CFP1. /evidence=ECO:0000250|UniProtKB:O15047 1424..1459
N-SET 1434..1571 CDD:314603
Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000250|UniProtKB:O15047 1459..1546
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1480..1508
WDR5 interaction motif (WIN). /evidence=ECO:0000250|UniProtKB:O15047 1501..1506
SET 1577..1700 CDD:214614
PostSET 1700..1716 CDD:214703
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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